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Leanne Hodson Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK

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Fredrik Karpe Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Oxford University Hospital Trusts, Oxford, UK

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hepatic glucose and lipid metabolism by direct and indirect mechanisms ( 1 ). For example portal insulin acts on the liver to directly activate glycogen synthesis and de novo lipogenesis (DNL) and inhibit gluconeogenesis, whilst peripherally insulin may

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0350
Volume/Issue:
Volume 8: Issue 10
Open access
Karim Gariani Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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of carbohydrates leading to de novo lipogenesis) ( 2 , 13 , 23 , 24 , 25 , 26 ). Nevertheless, some endocrine diseases are also associated with NAFLD and NASH ( Table 1 ), and their pathophysiology will be discussed. Table 1 Endocrine

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0490
Volume/Issue:
Volume 10: Issue 2
Open access
Helle Keinicke Insulin and Device Trial Operations, Novo Nordisk A/S, Søborg, Denmark

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Gao Sun Pharmacology and Histopathology, Novo Nordisk A/S, China

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Caroline M Junker Mentzel Department of Experimental Animal Models, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark

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Merete Fredholm Department of Veterinary Clinical and Animal Science, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark

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Linu Mary John Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark

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Birgitte Andersen Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark

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Kirsten Raun Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark

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Marina Kjaergaard Global Obesity and Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark

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. ( https://doi.org/10.1016/j.cell.2005.12.022 ) 38 Postic C Girard J . Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice . Journal of Clinical Investigation 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0152
Volume/Issue:
Volume 9: Issue 8
Open access
Yu Lin State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Yingying Zhang State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Lei Xu Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng, People’s Republic of China

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Wei Long State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Chunjian Shan State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Hongjuan Ding State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Lianghui You State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Chun Zhao State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Zhonghua Shi State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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novo lipogenesis ( 21 ). Results of microarray analysis showed that pathways associated with pyruvate metabolism and TCA cycle were down-regulated, meaning that the de novo lipogenesis is suppressed, which in turn leads to the decrease of fat

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0584
Volume/Issue:
Volume 10: Issue 2
Open access
Xu Chen Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China

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Yi Tang Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China

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Shen Chen Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Wenhua Ling Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China

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Qing Wang Department of Toxicology, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou, People’s Republic of China

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hepatic de novo lipogenesis and may serve as a biomarker of NAFLD progression ( 21 ). Here, we combined two datasets from GSE database and found that hepatic IGFBP-2 expression as a hub gene was also reversely associated with steatosis and serum ALT

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0353
Volume/Issue:
Volume 10: Issue 10
Open access
Jana Ernst Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany

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Katharina Gert Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany

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Frank Bernhard Kraus Central Laboratory, University Hospital Halle (Saale), Ernst-Grube-Strasse, Halle (Saale), Germany

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Ulrike Elisabeth Rolle-Kampczyk Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany

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Martin Wabitsch Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany

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Faramarz Dehghani Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany

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Kristina Schaedlich Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany

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an enzyme machinery enabling them for the de novo synthesis of steroid hormones from cholesterol ( 8 ). Androgenic steroids exhibit a positive gradient from blood to adipose tissue with the precursor androstenedione and dehydroepiandrosterone as

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0549
Volume/Issue:
Volume 9: Issue 7
Open access
Kennett Sprogøe Ascendis Pharma A/S, Hellerup, Denmark

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Eva Mortensen Ascendis Pharma, Inc., Palo Alto, California, USA

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David B Karpf Ascendis Pharma, Inc., Palo Alto, California, USA

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Jonathan A Leff Ascendis Pharma, Inc., Palo Alto, California, USA

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in China Pfizer, Inc. PHA-794428 Permanently PEGylated GH Discontinued Novo Nordisk A/S NNCl126-0083 Permanently PEGylated GH Discontinued Ambrx, Inc. ARX201 Permanently PEGylated and mutated GH Discontinued Teva

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0203
Volume/Issue:
Volume 6: Issue 8
Open access
Huixing Liu Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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Daoquan Peng Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

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hypothyroidism. The altered functions are labeled in the presence of hypothyroidism. Red arrows mark actions of declined TH, and blue arrows mark actions of elevated TSH. TH decreases in hypothyroidism and then de novo lipogenesis (DNL) and the activity of HMG

Article Type:
Review Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-21-0002
Volume/Issue:
Volume 11: Issue 2
Open access
Peter Wolf Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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Yvonne Winhofer Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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Martin Krššák Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria

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Michael Krebs Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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hyperlipidemia, hyperinsulinemia and hyperglycemia ( 71 ). It remains to be investigated whether this is due to increased lipid oxidation promoted by GH and IGF-1 or due to alterations in hepatic lipid metabolism, i.e. de novo lipogenesis and lipolysis

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0031
Volume/Issue:
Volume 6: Issue 4
Open access
Anastasia P Athanasoulia-Kaspar Max Planck Institute of Psychiatry, Department of Internal Medicine, Endocrinology and Clinical Chemistry, Munich, Germany

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Kathrin H Popp Max Planck Institute of Psychiatry, Department of Internal Medicine, Endocrinology and Clinical Chemistry, Munich, Germany

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Gunter Karl Stalla Max Planck Institute of Psychiatry, Department of Internal Medicine, Endocrinology and Clinical Chemistry, Munich, Germany

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characterized by the maladaptive nature of the preoccupations and the inability of the subject to control these urges, and they mainly have a de novo onset after the initiation of the DA on the basis of a negative psychiatric history. Whereas the overall

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0030
Volume/Issue:
Volume 7: Issue 2
Open access