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Masafumi Tetsuka Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

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Misato Tanakadate Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

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, 9 , 10 , 11 , 12 ). Recently, we have demonstrated that the bovine oocyte cumulus complex (COC) undergoing IVM expresses two types of glucocorticoid metabolizing enzymes, namely 11β-hydroxysteroid oxidoreductase type1 (HSD11B1) and type2 (HSD11B

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Yufen Zhao College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Erge Namei College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Bingxue Yang College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Xiangnan Bao Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, PR China
National Center of Technology Innovation for Dairy Industry, Hohhot, PR China

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Wei Sun Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, PR China

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Gerile Subudeng College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Guifang Cao College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Haijun Li College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China

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Gui Wang Animal Genetic Breeding and Reproduction Research Center, Hetao College, Bayannur, PR China

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) or luteinizing hormone (LH) in rats ( 18 ) results in a transient increase in the amount of phosphorylated CX43 protein in cumulus–oocyte complexes (COCs). The intra-oocyte cAMP level is elevated immediately after stimulation with FSH ( 17 ) or LH

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Neil R Chappell Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA

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Beth Zhou Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA

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Amy K Schutt Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA

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William E Gibbons Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA

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Chellakkan S Blesson Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine and Family Fertility Center, Texas Children’s Hospital, Houston, Texas, USA

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these oocytes if fertilized is not yet understood. Although the mechanisms remain unknown, a prior study in neuronal tissue of mice exposed to androgen (DHEA) has shown impairment in Complex I of mitochondrial electron transport chain ( 26 ). Other

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Wioletta Pijacka
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Morag G Hunter
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Fiona Broughton Pipkin School of Biosciences, New Maternity Unit, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK

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Martin R Luck
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complexes were aspirated from 2 to 10 mm follicles and oocytes were selected according to a four-point scale based on the number of compact cumulus cell layers and granulation of the oocyte cytoplasm, as described previously (19) . Groups of 50–70 oocytes

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Hui Long Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Yanhong Nie Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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Li Wang Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Yong Lu Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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Yan Wang Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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Yijun Cai Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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Zhen Liu Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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Miaomiao Jia Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Qifeng Lyu Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Yanping Kuang Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

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Qiang Sun Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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larger than 3 mm in diameter. 33–38 h after hCG administration, monkeys were anesthetized with tiletamine hydrochloride (4 to 6 mg/kg, Zoletil 50; Virbac S.A.) intramuscularly, and cumulus-oocyte complexes were collected by laparoscopic follicular

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Rosalie Cabry Amiens University, Amiens, Haut-de-France, France

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Philippe Merviel Brest University, Brest, Bretagne, France

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Aicha Madkour Mohammed V University of Rabat, Reproductive Medicine, Rabat, Morocco

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Elodie Lefranc Amiens University, Amiens, Haut-de-France, France

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Florence Scheffler Amiens University, Amiens, Haut-de-France, France

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Rachel Desailloud Amiens University, Amiens, Haut-de-France, France

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Véronique Bach Amiens University, Amiens, Haut-de-France, France

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Moncef Benkhalifa Amiens University, Amiens, Haut-de-France, France

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in oestradiol levels, affecting oocyte maturation ( 51 ). Furthermore, PCB might damage the ovarian reserve, the follicular response to administered gonadotropins, and oocyte maturation ( 51 ). Indeed, exposure of immature porcine cumulus-oocyte

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Arpna Sharma Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Vijay Simha Baddela Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Frank Becker Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Dirk Dannenberger Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Torsten Viergutz Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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Jens Vanselow Leibniz Institute for Farm Animal Biology (FBN), Dummerstorf, Germany

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excessive lipid mobilization has been associated with metabolic and reproductive disorders ( 3 ) affecting both the cumulus oocyte complex morphology and embryo viability ( 4 ). Elevated plasma levels of PA, SA, OA and of linoleic acid have been shown in

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