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Gavin P Vinson and Caroline H Brennan

(the therapeutic corticosteroid of choice at the time) was soon applied in the management of meperidine and morphine withdrawal symptoms in men (5) , apparently with beneficial effects, while Lovell associated alcoholism and drug addiction with

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Lesley A Hill, Zeynep Sumer-Bayraktar, John G Lewis, Eva Morava, Morten Thaysen-Andersen, and Geoffrey L Hammond

Introduction Corticosteroid-binding globulin (CBG) transports steroids in the blood and regulates their access to tissues and cells ( 1 , 2 ). Crystal structure analyses show that CBG contains a single hydrophobic steroid-binding site ( 3

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Muriel Houang, Thao Nguyen-Khoa, Thibaut Eguether, Bettina Ribault, Séverine Brabant, Michel Polak, Irène Netchine, and Antonin Lamazière

discriminant test, we questioned the mother regarding her medication. The mother happened to be on nasal spray corticosteroids (triamcinolone) throughout the pregnancy and during the neonatal period while she was breastfeeding. This significantly lowered all

Open access

Britt J van Keulen, Michelle Romijn, Bibian van der Voorn, Marita de Waard, Michaela F Hartmann, Johannes B van Goudoever, Stefan A Wudy, Joost Rotteveel, and Martijn J J Finken

/kg/day). Outcomes were: (1) cortisol excretion rate (µg/kg/day), (2) the sum of all glucocorticoid metabolites or corticosteroid excretion rate (µg/kg/day), and (3) the ratio of 11-hydroxy (11-OH)/11-oxoandrostenedione (11-OXO) metabolites, as an estimate of 11B

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Jana Ernst, Katharina Gert, Frank Bernhard Kraus, Ulrike Elisabeth Rolle-Kampczyk, Martin Wabitsch, Faramarz Dehghani, and Kristina Schaedlich

conditions, androgens (androstenedione, androsterone, testosterone, dihydrotestosterone, etiocholanolone) and corticosteroids (corticosterone, aldosterone, 11-deoxycortisol, cortisol, cortisone) increased during adipogenesis. Furthermore, an androstenedione

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Pablo Abellán-Galiana, Carmen Fajardo-Montañana, Pedro Riesgo-Suárez, Marcelino Pérez-Bermejo, Celia Ríos-Pérez, and José Gómez-Vela

specific treatment for hypercortisolism (ketoconazole and/or cabergoline) was suspended before surgery (at least 1 week), avoiding the use of corticosteroids in the surgical phase. Imaging studies using neuronavigation protocols were made, together with a

Open access

Athanasios D Anastasilakis, Marina Tsoli, Gregory Kaltsas, and Polyzois Makras

-up can be recommended. Intralesional corticosteroid injection, low-dose irradiation or surgical curettage have been used. However, complete surgical excision is not always recommended as it may sometimes increase the healing time and/or leave a large bone

Open access

Petar Milovanovic and Björn Busse

osteocyte death also occurs due to hormonal reasons, such as estrogen deficiency or corticosteroid excess ( 38 , 39 , 45 ). Moreover, osteocyte death may be caused by mechanical factors ( 36 , 46 ), but the relationship between mechanical loading and

Open access

Ruth Percik, Sherwin Criseno, Safwaan Adam, Kate Young, and Daniel L Morganstein

Checkpoint inhibitors are now widely used in the management of many cancers. Endocrine toxicity are amongst the most common side effects. These endocrinopathies differ form from most offer other immune related toxicities, in frequently being irreversible, but and rarely requiring cessation of checkpoint inhibitor therapy.

This review covers considers an approach to the presentation and diagnosis and presentation of these endocrinopathies, comparing to classical endocrine diagnosis, making recommendations for classification and treatment based on fundamental endocrine principles suggesting improvements to classification and treatment based on fundamental endocrine principles. These will help to align management with other similar endocrine conditions and standardise the diagnosis and reporting of endocrine toxicity of checkpoint inhibitors to improve both endocrine and oncological care.

In particular the importance of considering any inflammatory phase (such as painful thyroiditis or hypophysitis resulting in pituitary enlargement), form the endocrine consequences (transient hyperthyroidism followed by hypothyroidism, pan-hypopituitarism or isolated ACTH deficiency), is highlighted. It is also important to consider the potential confounder of exogenous corticosteroids in adrenal suppression.

Open access

Trevor Lewis, Eva Zeisig, and Jamie E Gaida

and associated metabolic conditions, such as insulin resistance ( 5 ), diabetes ( 6 ), hypercholesterolaemia ( 7 ), statins ( 8 ), abdominal fat ( 9 ), the sympathetic nervous system ( 10 , 11 ), and corticosteroid use ( 12 ). Glucocorticoids are a