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V Guarnotta, C Di Stefano, A Santoro, A Ciresi, A Coppola and C Giordano

Introduction Adrenal insufficiency (AI) is characterized by high morbidity and mortality, likely due to inappropriate glucocorticoid (GC) treatment and no physiological daily exposure. Indeed, conventional GC treatment, with hydrocortisone (HC

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L M Mongioì, R A Condorelli, S La Vignera and A E Calogero

hydrocortisone dose of 15–25 mg ( 8 ). The conventional treatment involves a double or triple administration of glucocorticoid, thus causing a supraphysiological cortisol exposition. Recently, a new once-daily dual-release hydrocortisone formulation has been

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Eva Novoa, Marcel Gärtner and Christoph Henzen

Introduction Intratympanic glucocorticoids are effective in the treatment of sudden sensorineural hearing loss (SSNHL) (1, 2, 3) , in the stabilization of Ménière's disease (MD) (4) , and in autoimmune ear disorders (5) . By the intratympanic

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Lia Ferreira, João Silva, Susana Garrido, Carlos Bello, Diana Oliveira, Hélder Simões, Isabel Paiva, Joana Guimarães, Marta Ferreira, Teresa Pereira, Rita Bettencourt-Silva, Ana Filipa Martins, Tiago Silva, Vera Fernandes, Maria Lopes Pereira and Adrenal Tumors Study Group of the Portuguese Society of Endocrinology

abnormal standard dose ACTH stimulation test (peak plasma cortisol <18 µg/dL); (3) characteristic clinical signs and symptoms such as hyperpigmentation, salt craving, typical electrolyte disturbances and chronic treatment with glucocorticoids and

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Janko Sattler, Jinwen Tu, Shihani Stoner, Jingbao Li, Frank Buttgereit, Markus J Seibel, Hong Zhou and Mark S Cooper

Background Acute inflammation is typically associated with an activation of the hypothalamo-pituitary-adrenal (HPA) axis, which results in an increase in the level of glucocorticoids within the circulation ( 1 ). In situations where this

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Filippo Ceccato, Diego Cecchin, Michele Gregianin, Giacomo Ricci, Cristina Campi, Filippo Crimì, Marta Bergamo, Annibale Versari, Carmelo Lacognata, Federico Rea, Mattia Barbot and Carla Scaroni

of the pancreas, pheochromocytoma, gastrointestinal carcinoids) ( 8 , 9 , 10 ). In the larger series reported, patients with occult EAS represent 8–32% of described cases ( 7 , 9 , 11 , 12 ). Once EAS is suspected, conventional imaging is

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Sylvia Thiele, Anke Hannemann, Maria Winzer, Ulrike Baschant, Heike Weidner, Matthias Nauck, Rajesh V Thakker, Martin Bornhäuser, Lorenz C Hofbauer and Martina Rauner

Introduction Glucocorticoids (GCs) are effective drugs in the treatment of immune-mediated diseases, including rheumatoid arthritis or allergic diseases such as asthma. However, their administration is often accompanied by adverse effects on

Open access

Kathrin R Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf and Marcus Quinkler

Introduction In states of adrenal insufficiency (AI), such as primary adrenal insufficiency (PAI) and congenital adrenal hyperplasia (CAH), glucocorticoids (GCs) are given in low doses as hormone replacement therapy. However, the daily intake

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Filippo Ceccato, Elisa Selmin, Chiara Sabbadin, Miriam Dalla Costa, Giorgia Antonelli, Mario Plebani, Mattia Barbot, Corrado Betterle, Marco Boscaro and Carla Scaroni

). Furthermore, the clinical picture of SAI may be complicated by the association of other pituitary deficiencies, which could affect both HPA axis and glucocorticoid (GC) treatment ( 5 ). A more severe degree of AI could characterize PAI, due to the impairment

Open access

Ferdinand Roelfsema, Diana van Heemst, Ali Iranmanesh, Paul Takahashi, Rebecca Yang and Johannes D Veldhuis

Lovas K Circadian hormone profiles and insulin sensitivity in patients with Addison’s disease: a comparison of continuous subcutaneous hydrocortisone infusion with conventional glucocorticoid replacement therapy . Clinical Endocrinology 2015 83