INSERM U1018, Université Paris Sud, Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, Bât 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Paris, Villejuif Cedex, France
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intensive glycaemic control does not reduce the risk of CVD in older patients with long-standing type 2 diabetes (13, 25, 26) . As type 2 diabetes affects cognitive function, intensive diabetes control may prevent the onset of microvascular disease in the
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Division of Interventional Cognitive Neurology, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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, 4 ); however, the underlying pathophysiology is not fully clarified. Animal data emphasize the importance of a balanced MR/glucocorticoid receptor (GR) system for cognitive functions ( 5 ) and support the role of MR in memory functions. Furthermore
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Introduction Growth hormone (GH) has been reported to have a role in improving cognitive function, both by inducing cognitive behaviors related to learning and memory and by affecting excitatory circuits involved in synaptic plasticity ( 1
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lack the decline in cognitive ability in the Morris water maze test that is observed in WT mice ( 9 , 10 ). GHRHKO mice represent an animal model of isolated GH deficiency with otherwise normal pituitary function ( 11 ). We have recently demonstrated
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Department of Florey Institute, University of Melbourne, Parkville, Victoria, Australia
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. Testosterone, and its derivatives, dihydrotestosterone (DHT) and estradiol (E2), have diverse functions in mammalian physiology ( 2 ). Androgen receptors and estradiol receptors are distributed in cortical and subcortical brain regions responsible for cognitive
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developed to assess general HRQoL ( 8 ). PROMs cover multiple domains of health that are influenced by patient’s subjective experiences, perceptions, and beliefs ( 9 ). These include pain, physical functioning, mobility, mood and other important areas of
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Objective: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is rare, and manifestations of autonomic dysregulation are diverse and may be overlooked. We aimed to evaluate the incidence of these manifestations.
Methods: Patients with ROHHAD syndrome reported before and after 2019 were divided into Groups 1 and 2. Patients who were diagnosed at three regional hospitals in China were included in Group 3. We collected the age of each specific term of the ROHHAD (neurogenic tumor, NET) acronym and the detailed manifestations of each term, and compared them among the three groups.
Results: A total of 16 patients were diagnosed within the 2-year period. Two had neurogenic tumors and cognitive and behavioral abnormalities before developing rapid obesity. At least 93.8% of the patients had ≥ 4 symptoms of autonomic dysregulation. When comparing autonomic dysregulation among Groups 1–3, the rates of cardiovascular manifestations were NA vs. 12.8% vs. 81.2%; gastrointestinal disturbances were 11.4% vs. 8.5% vs. 62.5%; strabismus was 25.7% vs. 12.8% vs. 62.5%; sleep disturbance was NA vs. 6.4% vs. 50.0%; and abnormal pain threshold was NA vs. 10.6% vs. 25.0% (all p<0.05). The rates of cognitive and behavioral abnormalities were NA vs 29.8% and 87.5% (p<0.01).
Conclusions: Rapid-onset obesity is not always the first sign of ROHHAD syndrome. Higher rates of autonomic dysregulation and cognitive and behavioral abnormalities with multiple manifestations of autonomic dysregulation coexisted in our cohort, indicating that evaluations of autonomic function and the limbic system should be strengthened when assessing this condition.
PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
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Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Neuroradiology Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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Neurosurgery Unit of University Hospital ‘AOU Policlinico G. Martino’, Messina, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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Department of Biomorphology, University of Messina, Messina, Sicily, Italy
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PhD School of Clinical and Experimental Biomedical Sciences, University of Messina, Messina, Sicily, Italy
Department of Human Pathology ‘G. Barresi’, University of Messina, Messina, Sicily, Italy
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prolactinoma too, underwent two cycles of PRRT with 177 Lu-DOTATOC (total activity 12.6 GBq) in 2015. In the same year, a third case (woman, 53 years old) with a giant non-functioning PT (NFPT) was treated with 177 Lu-DOTATOC (five cycles, total activity 29
TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Sophia Children’s Hospital, Dr. Molewaterplein, Rotterdam, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Department of Clinical, Neuro, and Developmental Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat, Amsterdam, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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. Neurocognitive impairments may serve as sensitive early predictors of behavioral problems in later life, may function as markers for children with an ‘at-risk’ development (e.g. identify those that do not meet age-specific norms for language, cognitive, and motor
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executive functioning, self-regulation, working memory, planning skills and abstract reasoning might emerge – Organize psychological testing and support (complex cognitive processes), if necessary Vocational planning should start – Support emancipating from