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Maria Angela D'amico, Barbara Ghinassi, Pascal Izzicupo, Lamberto Manzoli, and A Di Baldassarre

, neurotransmitters, or amines in response to a variety of physiological and pharmacological stimuli. Nine members of the granin family have been presently described: chromogranins, namely chromogranins A (CgA) and B (CgB), and secretogranins, namely SgII, 1B1075

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Jens P Goetze, Linda M Hilsted, Jens F Rehfeld, and Urban Alehagen

from the adrenal medulla is chromogranin A, or CgA (1) . CgA measurement in plasma has a central role in the diagnosis and treatment follow-up of neuroendocrine tumors, since these tumors often produce vast amounts of CgA (2, 3, 4) . In the

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R C S van Adrichem, L J Hofland, R A Feelders, M C De Martino, P M van Koetsveld, C H J van Eijck, R R de Krijger, D M Sprij-Mooij, J A M J L Janssen, and W W de Herder

Introduction Gastroenteropancreatic neuroendocrine tumors (GEP NETs) are rare and heterogeneous tumors which may vary according to their biological, functional, and clinical behavior (1) . Chromogranin A (CgA) and the Ki-67 proliferation index are

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Irvin M Modlin, Harry Aslanian, Lisa Bodei, Ignat Drozdov, and Mark Kidd

has remained a substantial technical challenge. A diverse variety of potential biomarkers has been proposed to be of utility in NET disease (2, 3, 4, 5) . These include the constitutive neurosecretory protein chromogranin A (CgA) as well as individual

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Małgorzata Fuksiewicz, Maria Kowalska, Agnieszka Kolasińska-Ćwikła, Jarosław B Ćwikła, Łukasz Sawicki, Katarzyna Roszkowska-Purska, Joanna Drygiel, and Beata Kotowicz

monitoring use the ability of NEN cells to release non-specific markers into the bloodstream. The determination of non-specific marker – chromogranin A (CgA) – is applied in clinical practice ( 2 , 3 ). This substance belongs to acid glycoproteins

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Anna Malczewska, Kjell Oberg, and Beata Kos-Kudla

prognostic studies (REMARK) . Journal of the National Cancer Institute 2005 97 1180 – 1184 . ( https://doi.org/10.1093/jnci/dji237 ) 5 O'Connor DT Bernstein KN Radioimmunoassay of chromogranin A in plasma as a measure of exocytotic

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Irasema Mendieta, Rosa Elvira Nuñez-Anita, Gilberto Pérez-Sánchez, Lenin Pavón, Alfredo Rodríguez-Cruz, Guadalupe García-Alcocer, and Laura Cristina Berumen

-like structures ( 5 ). Such tumours also express neuroendocrine markers such as chromogranin A (CgA) ( 6 ), synaptophysin, neuronal enolase and CD56 ( 7 , 8 , 9 , 10 ). A key aspect of the neuroendocrine phenotype is the formation of granules that secrete

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T Szarvas, B Jardin-Watelet, N Bourgoin, M J Hoffmann, P Nyirády, C Oláh, T Széll, A Csizmarik, B Hadaschik, and H Reis

Introduction Chromogranin A (CGA) is a 49 kDa glycoprotein encoded by the chromogranin A gene on chromosome 14q32.12. It belongs to the granin family of secretory proteins that are ubiquitous in the nervous, endocrine and immune systems. It is

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Klaus W Fagerstedt, Tom Böhling, Harri Sihto, Tarja Salonen, Fang Zhao, Mia Kero, Leif C Andersson, and Johanna Arola

with chromogranin A. Clear granular cytoplasmic staining can be seen as well as one mitotic figure (asterisk). All the scale bars represent 100 µm. GNEN-1 cells growth in semi-solid matrix, Matrigel ® GNEN-1 cells were first grown into

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Kjell Oberg, Eric Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P Baum, Matthew Kulke, Marianne Pavel, Jaroslaw Cwikla, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert Jensen, Klaus Koopmans, Tiny Korse, Dik Kwekkeboom, Helmut Maecke, Giovanni Paganelli, Ramon Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjaer, and Irvin M Modlin

identification and delineation of residual (and occult) disease is difficult. Credible general biomarkers with broad clinical utility for gastroenteropancreatic (GEP) NENs remain unavailable although chromogranin A (CgA) and urinary 5-hydroxyindoleacetic acid