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Jens F Rehfeld Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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basic and clinical endocrinology. The following story about cholecystokinin (CCK) illustrates how studies of a single peptide hormone from the gut (CCK-33) has gradually contributed to expand endocrinology into a considerably wider concept than just

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-21-0025
Volume/Issue:
Volume 10: Issue 3
Open access
Ulrik Ø Andersen Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Dijana Terzic Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Nicolai Jacob Wewer Albrechtsen Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Peter Dall Mark Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Peter Plomgaard Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jens F Rehfeld Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark

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Finn Gustafsson Department of Cardiology, Rigshospitalet, Copenhagen, Denmark

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Jens P Goetze Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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substance P, are known substrates of neprilysin ( 1 , 4 ). So far, only indirect experiments have suggested that neprilysin degrades gastrin and cholecystokinin (CCK) ( 5 , 6 , 7 , 8 , 9 , 10 ). These hormones are secreted in parallel with GLP-1 from

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0563
Volume/Issue:
Volume 9: Issue 5
Open access
H Vlaardingerbroek Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands
Willem-Alexander Children’s Hospital, Department of Pediatrics, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands

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E L T van den Akker Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands

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A C S Hokken-Koelega Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children’s Hospital, Rotterdam, The Netherlands

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. Figure 1 Neuroendocrine factors and interactions in the hypothalamus. In the gastrointestinal tract, multiple neuroendocrine hormones are produced. Ghrelin is the only gut hormone that stimulates feeding. Other hormones, including cholecystokinin (CCK

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-21-0111
Volume/Issue:
Volume 10: Issue 5
Open access
Bjarke R Medici Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Birte Nygaard Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jeppe L la Cour Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark

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Martin Krakauer Department of Clinical Physiology and Nuclear Medicine, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark

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Andreas Brønden Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark

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Mette P Sonne Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark

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Jens J Holst Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jens F Rehfeld Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Tina Vilsbøll Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark

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Jens Faber Department of Medicine, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Filip K Knop Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Herlev, Denmark

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, glucagon-like peptide 1 (GLP-1), cholecystokinin (CCK), and gastrin), gastric emptying (acetaminophen) and glucose homeostasis (glucose, insulin, and C-peptide) was collected at the same time points, while blood samples for thyroid status (TSH, free

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0314
Volume/Issue:
Volume 12: Issue 10
Open access
Gaëtan Prévost Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Marie Picot Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Marie-Anne Le Solliec Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Arnaud Arabo Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Hind Berrahmoune Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Mouna El Mehdi Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Saloua Cherifi Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Alexandre Benani Center for Taste and Feeding Behaviour, CNRS (UMR6265), INRA (UMR1324), Université de Bourgogne-Franche Comté, Dijon , France

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Emmanuelle Nédélec Center for Taste and Feeding Behaviour, CNRS (UMR6265), INRA (UMR1324), Université de Bourgogne-Franche Comté, Dijon , France

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Françoise Gobet Department of Anatomopathophysiology, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France

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Valéry Brunel Department of Biochemistry, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France

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Jérôme Leprince Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Hervé Lefebvre Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France
Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France

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Youssef Anouar Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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Nicolas Chartrel Normandie Univ, UNIROUEN, INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (DC2N), Rouen, France

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note that the role of various peptides/hormones of the gut such as cholecystokinin, secretin, GIP, VIP, in the secretion of gastrin, pepsin, HCl is clearly established and widely documented ( 34 ) and that some of them such as cholecystokinin, GIP or

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0247
Volume/Issue:
Volume 8: Issue 7
Open access
Lin Ji Department of Cell Biology & Medical Genetics, School of Medicine, Shenzhen University, Shenzhen, China

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Huan-Tong Wu Beijing Engineering Research Center of Food Environment and Health, College of Life & Environmental Sciences, Minzu University of China, Beijing, China

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Xiao-Yan Qin Beijing Engineering Research Center of Food Environment and Health, College of Life & Environmental Sciences, Minzu University of China, Beijing, China

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Rongfeng Lan Department of Cell Biology & Medical Genetics, School of Medicine, Shenzhen University, Shenzhen, China

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, promelanin-concentrating hormone, progastrin and pro-opiomelanocortin (POMC), as well as reduced levels of bioactive peptides such as insulin, adrenocorticotropic hormone (ACTH), neurotensin, cholecystokinin (CCK) and gastrin in Cpe fat /Cpe fat mice

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0020
Volume/Issue:
Volume 6: Issue 4
Open access
Benjamin Paul Green Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne NE1 8ST, UK

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Javier Thomas Gonzalez Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne NE1 8ST, UK

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Kevin Thomas Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne NE1 8ST, UK

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Emma Stevenson Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne NE1 8ST, UK

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Penny Louise Sheena Rumbold Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Northumberland Building, Newcastle upon Tyne NE1 8ST, UK

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Horowitz M Feinle-Bisset C . Reproducibility of energy intake, gastric emptying, blood glucose, plasma insulin and cholecystokinin responses in healthy young males . British Journal of Nutrition 2009 101 1094 . ( doi:10.1017/S0007114508042372

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0110
Volume/Issue:
Volume 3: Issue 4
Open access
Caishun Zhang Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, China

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Junhua Yuan Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, China

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Qian Lin Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, China

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Manwen Li Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, China

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Liuxin Wang Hyperbaric Oxygen Therapy Department, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China

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Rui Wang Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, China

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Xi Chen Physiology Department, College of Basic Medicine, Qingdao University, Qingdao, China

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Zhengyao Jiang Physiology Department, College of Basic Medicine, Qingdao University, Qingdao, China

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Kun Zhu Intensive Care Unit Department, Affiliated Hospital of Qingdao University, Qingdao, China

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Xiaoli Chang Institute of Acupuncture, Shandong University of Traditional Chinese Medicine, Jinan, China

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Bin Wang Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, China
Medical Microbiology Department, College of Basic Medicine, Qingdao University, Qingdao, China

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Jing Dong Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, China
Physiology Department, College of Basic Medicine, Qingdao University, Qingdao, China

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AS Shah BP Madara JC Burke LK Patterson CM Flak J Neve RL Evans ML Lowell BB Myers Jr MG et al . A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia . Cell Metabolism 2014

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0285
Volume/Issue:
Volume 9: Issue 12
Open access
Christine Rode Andreasen Steno Diabetes Center Copenhagen, Gentofte, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Andreas Andersen Steno Diabetes Center Copenhagen, Gentofte, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Filip Krag Knop Steno Diabetes Center Copenhagen, Gentofte, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Tina Vilsbøll Steno Diabetes Center Copenhagen, Gentofte, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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development, and their therapeutic potential for the treatment of T2D and obesity is being investigated in clinical trials ( 55 , 90 , 91 , 92 ). Also, the combination of GLP-1RA with cholecystokinin (CCK) and fibroblast growth factor 21 (FGF21) has been

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-21-0130
Volume/Issue:
Volume 10: Issue 7
Open access