Timothy J Morris
Timothy J Morris
Directorate of Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK
Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK
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Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK
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Andrew Whatmore
Andrew Whatmore
Division of Developmental Biology and Medicine, University of Manchester, Royal Manchester Children’s Hospital, Manchester, UK
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Laura Hamilton
Laura Hamilton
Pathology Department, Clinical Biochemistry, Huddersfield Royal Infirmary, Lindley, Huddersfield, UK
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Beverly Hird
Beverly Hird
Directorate of Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK
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Eric S Kilpatrick
Eric S Kilpatrick
Directorate of Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK
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Lesley Tetlow
Lesley Tetlow
Directorate of Biochemistry, Manchester University NHS Foundation Trust, Manchester, UK
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Peter Clayton
Peter Clayton
Division of Developmental Biology and Medicine, University of Manchester, Royal Manchester Children’s Hospital, Manchester, UK
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.1) Values are mean ( s.d. ) with significant differences between assays highlighted in bold (one-way ANOVA). a P = 0.008. Significantly more children had their dose increased using the PRC (24/44, 55%) compared to the PRA (16/47, 34
Thomas Reinehr
Thomas Reinehr
Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Witten, Germany
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Alberto Sánchez-Guijo
Alberto Sánchez-Guijo
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Giessen, Germany
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Nina Lass
Nina Lass
Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Witten, Germany
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Stefan A Wudy
Stefan A Wudy
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University Giessen, Giessen, Germany
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Introduction Obesity is a complex condition associated with changes in many steroid hormones also including androgens: concentrations of testosterone and DHEAS and their precursors are increased in children ( 1 , 2 ) and obese women ( 3
Giorgio Radetti
Giorgio Radetti
Pediatrics, Regional Hospital, Bolzano, Italy
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Mariacarolina Salerno
Mariacarolina Salerno
Pediatrics, University Federico II, Naples, Italy
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Chiara Guzzetti
Chiara Guzzetti
Pediatric Endocrinology, Ospedale Pedatrico Microcitemico ‘A. Cao’ – AOB Cagliari, Cagliari, Italy
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Marco Cappa
Marco Cappa
Pediatric Endocrinology, Bambino Gesù Children Hospital, Roma, Italy
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Andrea Corrias
Andrea Corrias
Divisione di Endocrinologia Pediatrica, Ospedale Infantile Regina Margherita, Torino, Italy
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Alessandra Cassio
Alessandra Cassio
Department of Pediatrics, University of Bologna, Bologna, Italy
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Graziano Cesaretti
Graziano Cesaretti
Department of Pediatrics, University of Pisa, Pisa, Italy
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Roberto Gastaldi
Roberto Gastaldi
Paediatric Department, Gaslini Hospital, Genova, Italy
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Mario Rotondi
Mario Rotondi
Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I.R.C.C.S., ISPESL Laboratory for Endocrine Disruptors, University of Pavia, Pavia, Italy
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Fiorenzo Lupi
Fiorenzo Lupi
Pediatrics, Regional Hospital, Bolzano, Italy
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Antonio Fanolla
Antonio Fanolla
Department of Biostatistics, Regional Hospital, Bolzano, Italy
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Giovanna Weber
Giovanna Weber
Department of Pediatrics, Vita-Salute San Raffaele University, Milan, Italy
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Sandro Loche
Sandro Loche
Pediatric Endocrinology, Ospedale Pedatrico Microcitemico ‘A. Cao’ – AOB Cagliari, Cagliari, Italy
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started in patients with either subclinical (high TSH with normal fT4) or overt hypothyroidism (subnormal fT4 and increased TSH). There is no consensus on the timing to start or discontinue therapy based on TSH concentrations in children and adolescents
Emmanuelle Motte
Emmanuelle Motte
UFR des Sciences de la Santé, Simone Veil, Université Versailles St-Quentin en Yvelines, Montigny le Bretonneux, France
Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
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Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
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Anya Rothenbuhler
Anya Rothenbuhler
Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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Stephan Gaillard
Stephan Gaillard
Department of Neurosurgery, Foch Hospital, Suresnes, France
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Najiba Lahlou
Najiba Lahlou
APHP, Department of Hormonal Biology, Cochin Hospital, Paris, France
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Cécile Teinturier
Cécile Teinturier
Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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Régis Coutant
Régis Coutant
Department of Pediatric Endocrinology, Angers University Hospital, Angers, France
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Agnès Linglart
Agnès Linglart
Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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therapy for CD in children, its efficacy and safety in this context has not been reported so far. We describe here the efficacy and safety of mitotane as treatment of CD in nine children in comparison to 13 patients cured by TSS. Table 1 Synopsis of
Annalisa Blasetti
Annalisa Blasetti
Department of Paediatrics, University of Chieti, Chieti, Italy
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Valeria Castorani
Valeria Castorani
Department of Paediatrics, University of Chieti, Chieti, Italy
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Nella Polidori
Nella Polidori
Department of Paediatrics, University of Chieti, Chieti, Italy
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Ilaria Mascioli
Ilaria Mascioli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Francesco Chiarelli
Francesco Chiarelli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Cosimo Giannini
Cosimo Giannini
Department of Paediatrics, University of Chieti, Chieti, Italy
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anthropometric development in children with T1D ( 1 , 2 ). The Mauriac syndrome, characterized by growth failure and hepatomegaly, constitutes the most critical growth-related condition characterized by long-term and poorly controlled T1D in relation to chronic
Vickie Braithwaite
Vickie Braithwaite
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Kerry S Jones
Kerry S Jones
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Shima Assar
Shima Assar
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Inez Schoenmakers
Inez Schoenmakers
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Ann Prentice
Ann Prentice
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Introduction Elevated plasma C-terminal fibroblast growth factor 23 (C-FGF23) concentrations have been recorded in Gambian children with putative Ca-deficiency rickets (1) and, at a lower prevalence, in apparently healthy children from the local
Martijn J J Finken
Martijn J J Finken
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Aleid J G Wirix
Aleid J G Wirix
Department of Public and Occupational Health, EMGO Institute for Health and Care Research, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Ines A von Rosenstiel-Jadoul
Ines A von Rosenstiel-Jadoul
Department of Pediatrics, Rijnstate Hospital, Arnhem, The Netherlands
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Bibian van der Voorn
Bibian van der Voorn
Department of Pediatric Endocrinology and Obesity Center CGG, Erasmus MC Sophia Children’s Hospital, Rotterdam, The Netherlands
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Mai J M Chinapaw
Mai J M Chinapaw
Department of Public and Occupational Health, EMGO Institute for Health and Care Research, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Michaela F Hartmann
Michaela F Hartmann
Steroid Research and Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Department of Pediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Joana E Kist-van Holthe
Joana E Kist-van Holthe
Department of Public and Occupational Health, EMGO Institute for Health and Care Research, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Stefan A Wudy
Stefan A Wudy
Steroid Research and Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Department of Pediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Joost Rotteveel
Joost Rotteveel
Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Introduction Rates of childhood obesity have steeply increased over the past decades ( 1 ). Nowadays, an estimated number of 107.7 million children suffer from obesity worldwide ( 1 ), and approximately 20% of them progress to hypertension ( 2
Amalie Carlsson
Amalie Carlsson
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
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International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
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Kaspar Sørensen
Kaspar Sørensen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
The Child and Youth Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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The Child and Youth Clinic, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Anna-Maria Andersson
Anna-Maria Andersson
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
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International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
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Hanne Frederiksen
Hanne Frederiksen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
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International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
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International Research and Research Training Center in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen, Denmark
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( 4 ) and obesity ( 5 ) in adults and obesity ( 6 ) in children. Phthalates are used as softeners in PVC plastics. As phthalates are continuously emitted from PVC, humans can be exposed through ingestion, inhalation or by dermal contact ( 7
Alessandro Ciresi
Alessandro Ciresi
Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy
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Stefano Radellini
Stefano Radellini
Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy
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Valentina Guarnotta
Valentina Guarnotta
Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy
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Maria Grazia Mineo
Maria Grazia Mineo
Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy
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Carla Giordano
Carla Giordano
Section of Endocrinology, Biomedical Department of Internal and Specialist Medicine (DIBIMIS), University of Palermo, Palermo, Italy
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relationship between GH and gonadal steroid levels in children is difficult to establish because steroid levels are very low prior to puberty. Therefore, although the clinical features related to sexual dimorphism of the somatotroph axis have been well
Anastasia Ibba
Anastasia Ibba
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Francesca Corrias
Francesca Corrias
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Chiara Guzzetti
Chiara Guzzetti
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Letizia Casula
Letizia Casula
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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Mariacarolina Salerno
Mariacarolina Salerno
Dipartimento di Pediatria, Università Federico II, Napoli, Italy
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Natascia di Iorgi
Natascia di Iorgi
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Gianluca Tornese
Gianluca Tornese
SSD Endocrinologia Pediatrica, Clinica Pediatrica, IRCCS Materno-infantile Burlo Garofolo, Trieste, Italy
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Giuseppa Patti
Giuseppa Patti
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Giorgio Radetti
Giorgio Radetti
Dipartimento di Pediatria, Ospedale Generale Regionale, Bolzano, Italy
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Mohamad Maghnie
Mohamad Maghnie
Dipartimento di Pediatria, IRCCS Istituto Giannina Gaslini, Università di Genova, Genova, Italy
Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Marco Cappa
Marco Cappa
UOC di Endocrinologia, Dipartimento Universitario Ospedaliero, Ospedale Pediatrico Bambino Gesù IRCCS, Roma, Italy
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Sandro Loche
Sandro Loche
SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico Microcitemico, ‘A. Cao’, AO Brotzu, Cagliari, Italy
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do not exclude GHD. In the current retrospective study we aimed to define the best IGF1 SDS diagnostic cut-off using a standardized assay in a large cohort of children and adolescents with short stature. Furthermore, we wanted to evaluate through
