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Introduction Nonsyndromic childhood obesity is associated with nonalcoholic fatty liver disease (NAFLD), a spectrum of conditions, ranging from steatosis to nonalcoholic steatohepatitis (NASH), and various degrees of fibrosis and cirrhosis ( 1
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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). With more children surviving a brain tumor, it is evident that survivorship comes with a cost. Childhood brain tumor survivors have an increased risk of long-term and possibly lifelong morbidity affecting multiple organ systems ( 4 ). Compared to
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Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Endo-ERN European Reference Network on Rare endocrine conditions
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Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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hypothalamic dysfunction (HD), can be acquired in childhood or later on due to (treatment of) suprasellar brain tumors ( 1 ). Treatment modalities for suprasellar brain tumors may include neurosurgery, chemotherapy, radiotherapy or a combination of them ( 2
Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
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Department of Paediatric Endocrinology, Royal London Hospital, Barts Health NHS Trust, London, UK
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Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
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Centre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
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Department of Paediatric Endocrinology, Royal London Hospital, Barts Health NHS Trust, London, UK
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transformation ( 7 , 8 ). Approximately 72% of metastatic PPGLs in childhood are associated with SDHB mutations ( 3 ). This emphasises the importance of lifelong, regular surveillance for all children carrying SDHB mutations in an experienced centre as
TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Sophia Children’s Hospital, Dr. Molewaterplein, Rotterdam, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Department of Clinical, Neuro, and Developmental Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat, Amsterdam, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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vulnerability as well as the recognition of specific targets for early intervention. The TRIXY Early Childhood Study is a longitudinal study designed to identify early neurodevelopmental risks in children with SCT. Based on studies in adolescents and adults
Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital/ University Medical Center Utrecht, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
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Developmental Endocrinology Research Group, Royal Hospital for Children, University of Glasgow, Glasgow, UK
Office for Rare Conditions, University of Glasgow, Glasgow, UK
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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will not affect disease-specific morbidity and mortality, yet may reduce treatment-induced adverse outcome. As a consequence of the rarity of the disease during childhood and adolescence, current treatment guidelines are predominantly based on the
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Section Endocrinology, Department of Medicine, Erasmus MC, Rotterdam, The Netherlands
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Introduction Over the past decades, survival rates of childhood nephroblastoma and neuroblastoma have increased to respectively ~90% and ~40–95% (strongly dependent on stadium) ( 1 , 2 ). These tumours are of embryonic origin, with a peak
Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, AB Utrecht, The Netherlands
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Introduction Endocrine disorders affect up to 60% of childhood cancer survivors (CCS) ( 1 ). Cancer, brain tumors and their treatments have been associated with a higher risk of deficiencies in growth hormone (GH), thyroid hormone and sex
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Introduction Rates of childhood obesity have steeply increased over the past decades ( 1 ). Nowadays, an estimated number of 107.7 million children suffer from obesity worldwide ( 1 ), and approximately 20% of them progress to hypertension ( 2
Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland
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bodies, and a + pHL: HL involving anterior hypothalamic structures, mammillary bodies and hypothalamic areas dorsal of mammillary bodies ( Fig. 1 ). Figure 1 Presurgical (A, C and E) and postsurgical (B, D and F) MRIs of three childhood