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M L M Barreto-Chaves, N Senger, M R Fevereiro, A C Parletta and A P C Takano

also observed after 2 weeks of discontinuation of treatment with T4, including cardiac hypertrophy ( 53 ). TH in cardiac cells In cardiac tissue, TH exert their effects in cardiomyocytes, and other cardiac non-myocyte cells such as fibroblasts

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Madalena von Hafe, João Sergio Neves, Catarina Vale, Marta Borges-Canha and Adelino Leite-Moreira

contractile apparatus of the cardiac myocyte has two subtypes of myosin heavy chains (MHCs): α-MHC and β-MHC – fast and slow myosin, respectively. T3 can upregulate α-MHC and downregulate β-MHC ( 10 ). Therefore, the myocardial hypothyroid state induces a so

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Tsuneo Ogawa and Adolfo J de Bold

natriuretic peptide coexist in the secretory granules of human cardiac myocytes . American Journal of Hypertension 1991 4 909 – 912 . ( doi:10.1093/ajh/4.2.113 ). 20 Kojima M Minamino N Kangawa K Matsuo H

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Satoshi Higuchi, Hideki Ota, Takuya Ueda, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh and Kei Takase

radical injury, leading to myocyte membrane damage and death ( 25 , 26 ). Moreover, autopsies of patients who died due to pheochromocytoma showed cardiac lesions, such as focal degeneration and necrosis of myocardial fibers, foci of inflammatory cells and

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Frans H H Leenen, Mordecai P Blaustein and John M Hamlyn

expression; this fosters Ca 2+ extrusion and attenuates Ca 2+ signaling and contraction, thereby impairing systolic function ( 68 ). Note that the driving force on cardiac NCX1 favors Ca 2+ efflux during diastole whereas, in arteries with tone, the myocyte

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Hugo R Ramos, Andreas L Birkenfeld and Adolfo J de Bold

–88 pg/ml). These findings posed the question as to why it is that in some patients the plasma levels of cardiac natriuretic peptides (cNP) are unexpectedly low, and what is their value in the prognosis for these patients? The cardiologist's perspective

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Akinori Sairaku, Yukiko Nakano, Yuko Uchimura, Takehito Tokuyama, Hiroshi Kawazoe, Yoshikazu Watanabe, Hiroya Matsumura and Yasuki Kihara

arterioles, impaired blood flow, and maladaptive changes in the myocyte shape ( 17 ). All these unfavorable effects of overt hypothyroidism on the heart were responsible for an increase in the left ventricular end-diastolic pressure ( 18 ), leading to

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Adriana J van Ballegooijen, Marjolein Visser, Marieke B Snijder, Jacqueline M Dekker, Giel Nijpels, Coen D A Stehouwer, Michaela Diamant and Ingeborg A Brouwer

:10.1111/j.1753-4887.2008.00100.x ). 2 Nibbelink KA Tishkoff DX Hershey SD Rahman A Simpson RU . 1,25(OH)2-vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte . Journal of

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Rossella Cannarella, Teresa Mattina, Rosita A Condorelli, Laura M Mongioì, Giuseppe Pandini, Sandro La Vignera and Aldo E Calogero

/growth retardation − 20. % (4/20) No 22.4% (11/49) 11.8% (2/17) 25% (13/52) Yes 100% Yes Cardiac malformations − 33.3% (6/18) Yes 50.0% (18/36) 16.7% (1/6) 47.9% (23/48) No 30% Yes Kidneys malformations − 38.9% (7

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K Amrein, A Papinutti, E Mathew, G Vila and D Parekh

, binding to vitamin D receptors (VDR) on cardiac myocytes and furthermore by having antioxidant properties that may reduce levels of reactive oxygen species (ROS) in the atria, which contribute to inflammation and proarrhythmic substrate formation ( 79