treatment was defined as resistance. In resistant patients, maximum dose of cabergoline used was 7 mg/week and if still unresponsive, second line therapies were offered. Second line management includes trans-sphenoidal surgery (TSS) by a single experienced
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Shruti Khare, Anurag R Lila, Hiren Patt, Chaitanya Yerawar, Manjunath Goroshi, Tushar Bandgar, and Nalini S Shah
Hélène Lasolle, Amandine Ferriere, Alexandre Vasiljevic, Sandrine Eimer, Marie-Laure Nunes, and Antoine Tabarin
, pegvisomant (PEG), is a second-line treatment which normalizes IGF-1 plasma levels in 60–70% ( 5 ) of patients in follow-up registries and up to 97% in single-center series ( 6 ). The dopamine D2-receptor agonist, cabergoline, is an alternative to 1 GSSA
Anastasia P Athanasoulia-Kaspar, Kathrin H Popp, and Gunter Karl Stalla
.09.1998–01.03.1999; 24.06.1999–03.12.2001) with interruptions and in combination with cabergoline (02.10.1998–07.10.1999; 03.12.2001-ongoing). Interestingly, the psychiatric symptoms were similar under all dopamine agonists administered with the ICD codes including
Sarah Byberg, Jesper Futtrup, Mikkel Andreassen, and Jesper Krogh
is mediated through prolactin-induced increase in cardiovascular risk factors including obesity, dyslipidemia and insulin resistance ( 4 , 5 , 6 , 7 , 8 , 9 , 10 ). In a German population-based cohort study, prolactin levels within the normal
G Giuffrida, F Ferraù, R Laudicella, O R Cotta, E Messina, F Granata, F F Angileri, A Vento, A Alibrandi, S Baldari, and S Cannavò
in reducing tumor volume and controlling hormonal hypersecretion, if present ( 3 ). Nevertheless, aggressive PT can be characterized by rapid growth, resistance and/or recurrence despite conventional treatments, making their management extremely
Bernardo Maia, Leandro Kasuki, and Mônica R Gadelha
, gastrointestinal, injection-site reactions Cabergoline (4, 22, 26) Dopamine receptor agonist 1.5–3.5 mg/week, PO (by mouth) 18 Tumor shrinkage (33%) Gastrointestinal, nasal congestion, fatigue, orthostasis, headache, cardiac valve abnormalities
Adrian F Daly, Liliya Rostomyan, Daniela Betea, Jean-François Bonneville, Chiara Villa, Natalia S Pellegata, Beatrice Waser, Jean-Claude Reubi, Catherine Waeber Stephan, Emanuel Christ, and Albert Beckers
( 9 ). The molecular mechanism for this relative somatostatin analog resistance may occur via Gai proteins or ZAC1, which are themselves important mediators of SST2 actions ( 11 , 12 , 13 ). Given the relatively poor results achieved with first
Adrian F Daly, David A Cano, Eva Venegas-Moreno, Patrick Petrossians, Elena Dios, Emilie Castermans, Alvaro Flores-Martínez, Vincent Bours, Albert Beckers, and Alfonso Soto-Moreno
limit of normal in association with a macroadenoma on MRI. Lack of hormonal control (DA resistance) was defined as per Molitch ( 17 ) as a failure to achieve normalization of serum prolactin at the highest labeled dose of cabergoline (2 mg
Peter Wolf, Alexandre Dormoy, Luigi Maione, Sylvie Salenave, Jacques Young, Peter Kamenický, and Philippe Chanson
mortality, mainly because of cardio-metabolic complications ( 1 , 2 , 3 ). Impaired glucose metabolism is frequently observed in acromegaly. It is mainly caused by the insulin-antagonizing effects of GH-inducing hepatic and peripheral insulin resistance
Teresa Vilariño-García, Antonio Pérez-Pérez, Esther Santamaría-López, Nicolás Prados, Manuel Fernández-Sánchez, and Víctor Sánchez-Margalet
participation of Sam68 in leptin signaling ( 6 ), we aim to investigate the role of this protein in the signal transduction pathways that are activated by leptin in granulosa cells from healthy controls. Leptin resistance is a common finding in obesity, where
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