Anne M Drewes
Anne M Drewes
University of Aarhus, Aarhus C, Denmark
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Maria E Møller
Maria E Møller
The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark
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Rasmus Hertzum-Larsen
Rasmus Hertzum-Larsen
The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark
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Gerda Engholm
Gerda Engholm
The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark
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Hans H Storm
Hans H Storm
The Danish Cancer Society, Denmark (Kræftens Bekæmpelse), København Ø, Denmark
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. Apart from ionising radiation, we have limited knowledge on risk factors for brain tumours, and for breast cancer hormone-related factors, for example, null parity, late age pregnancies, overweight, alcohol consumption and genetic mutations ( BRCA1 and
Nikolaos Kyriakakis
Nikolaos Kyriakakis
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Marilena Giannoudi
Marilena Giannoudi
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Satish S Kumar
Satish S Kumar
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Khyatisha Seejore
Khyatisha Seejore
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Georgios K Dimitriadis
Georgios K Dimitriadis
Department of Endocrinology, King’s College Hospital NHS Foundation Trust, Denmark Hill, London, UK
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Harpal Randeva
Harpal Randeva
Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK
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Adam Glaser
Adam Glaser
Pediatric Oncology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute of Medical Research, University of Leeds, UK
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Leeds Institute of Medical Research, University of Leeds, UK
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Michelle Kwok-Williams
Michelle Kwok-Williams
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Georgina Gerrard
Georgina Gerrard
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Carmel Loughrey
Carmel Loughrey
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Ahmed Al-Qaissi
Ahmed Al-Qaissi
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Ramzi Ajjan
Ramzi Ajjan
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Julie Lynch
Julie Lynch
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
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Robert D Murray
Robert D Murray
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Introduction Malignant brain tumours affect both children and adults, although have markedly different long-term outcomes. Five-year survival rates of 73% have been reported following multi-modality treatment in children diagnosed with
David S McLaren
David S McLaren
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK
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Aarani Devi
Aarani Devi
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospital NHS Trust, Leeds, UK
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Nikolaos Kyriakakis
Nikolaos Kyriakakis
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK
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Michelle Kwok-Williams
Michelle Kwok-Williams
Clinical Oncology, Leeds Cancer Centre, Leeds Teaching Hospital NHS Trust, Leeds, UK
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Robert D Murray
Robert D Murray
Department of Endocrinology, Leeds Centre for Diabetes & Endocrinology, Leeds Teaching Hospital NHS Trust, Leeds, UK
Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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impact on young developing brains, particularly in children under the age of 3 years. Exposure of healthy brain tissue to radiation, however, continues to occur during treatment of most central nervous system tumours, skull base, parameningeal, selective
Izabelle Lövgren
Izabelle Lövgren
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
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Azadeh Abravan
Azadeh Abravan
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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Abigail Bryce-Atkinson
Abigail Bryce-Atkinson
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
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Marcel van Herk
Marcel van Herk
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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in Fig. 1 ( 3 ). Standard photon-beam RT treatments deliver 1.8–2.0 Gray (Gy) fractions of radiation dose 5 days a week for 4–6 weeks ( 3 ). The most common types of RT used for paediatric brain tumours are 3D conformal RT (3DCRT) and intensity
Enora Le Roux
Enora Le Roux
Université de Paris, ECEVE UMR 1123, Inserm, Paris, France
AP-HP.Nord-Université de Paris, Hôpital Universitaire Robert Debré, Unité d’Épidémiologie Clinique, Inserm, Paris, France
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AP-HP.Nord-Université de Paris, Hôpital Universitaire Robert Debré, Unité d’Épidémiologie Clinique, Inserm, Paris, France
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Florence Menesguen
Florence Menesguen
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service d’Endocrinologie et Médecine de la Reproduction, Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Isabelle Tejedor
Isabelle Tejedor
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service d’Endocrinologie et Médecine de la Reproduction, Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Marc Popelier
Marc Popelier
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service de Diabétologie, Paris, France
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Marine Halbron
Marine Halbron
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service de Diabétologie, Paris, France
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Pauline Faucher
Pauline Faucher
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service de Nutrition, Centre du Syndrome de Prader-Willi et Autres Obésités Rares, Paris, France
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Sabine Malivoir
Sabine Malivoir
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service d’Endocrinologie et Médecine de la Reproduction, Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Graziella Pinto
Graziella Pinto
AP-HP.Université de Paris Centre, Hôpital Universitaire Necker Enfants Malades, Département d’Endocrinologie, Diabétologie et Gynécologie Pédiatrique, Paris, France; Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Juliane Léger
Juliane Léger
AP-HP.Nord-Université de Paris, Hôpital Universitaire Robert Debré, Service d’Endocrinologie Diabétologie Pédiatrique, Centre de Référence des Maladies Endocriniennes de la Croissance et du Développement, Paris, France
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Stephane Hatem
Stephane Hatem
Institute of Cardiology and Nutrition, Paris, France
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Michel Polak
Michel Polak
AP-HP.Université de Paris Centre, Hôpital Universitaire Necker Enfants Malades, Département d’Endocrinologie, Diabétologie et Gynécologie Pédiatrique, Paris, France; Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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Christine Poitou
Christine Poitou
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service de Nutrition, Centre du Syndrome de Prader-Willi et Autres Obésités Rares, Paris, France
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Philippe Touraine
Philippe Touraine
AP-HP. Sorbonne Université, Hôpital Universitaire Pitié Salpêtrière-Charles Foix, Service d’Endocrinologie et Médecine de la Reproduction, Centre de Maladies Endocriniennes Rares de la Croissance et du Développement, Centre de Pathologies Gynécologiques Rares, Paris, France
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) represent 3492 (36%) of coordination actions. Table 1 Cohort medical characteristics. n (%) Diseases Malignant brain tumour (except craniopharyngioma) 56 (11) Obesity 55 (11) Type 1 diabetes 54 (11
Kate E Lines
Kate E Lines
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Mahsa Javid
Mahsa Javid
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Anita A C Reed
Anita A C Reed
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Gerard V Walls
Gerard V Walls
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Mark Stevenson
Mark Stevenson
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Michelle Simon
Michelle Simon
MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK
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Kreepa G Kooblall
Kreepa G Kooblall
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Sian E Piret
Sian E Piret
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Paul T Christie
Paul T Christie
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Paul J Newey
Paul J Newey
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Ann-Marie Mallon
Ann-Marie Mallon
MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK
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Rajesh V Thakker
Rajesh V Thakker
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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p53 null mice (p53 -/- ) which develop multiple tumours similar to those in patients with the Li-Fraumeni syndrome (e.g. soft tissue sarcomas, osteosarcomas, breast cancer, brain tumours, leukaemia and adrenocortical carcinomas), bred on CE/J and 129
Eva Jakobsson Ung
Eva Jakobsson Ung
Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Ann-Charlotte Olofsson
Ann-Charlotte Olofsson
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
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Ida Björkman
Ida Björkman
Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden
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Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden
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Tobias Hallén
Tobias Hallén
Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden
Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden
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Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden
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Daniel S Olsson
Daniel S Olsson
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Oskar Ragnarsson
Oskar Ragnarsson
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Thomas Skoglund
Thomas Skoglund
Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden
Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden
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Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden
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Sofie Jakobsson
Sofie Jakobsson
Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden
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Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden
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Gudmundur Johannsson
Gudmundur Johannsson
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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. The patients stressed the fear of being diagnosed with a tumour, a disease they experienced as frightening because they relate it to cancer, in particular if a family member had previously died from cancer: ‘A tumour in my brain, how fast will it grow
Nadine M Vaninetti
Nadine M Vaninetti
Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, Canada
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David B Clarke
David B Clarke
Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
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Deborah A Zwicker
Deborah A Zwicker
Cape Breton Regional Hospital, Sydney, Nova Scotia, Canada
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Churn-Ern Yip
Churn-Ern Yip
Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, Canada
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Barna Tugwell
Barna Tugwell
Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, Canada
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Steve Doucette
Steve Doucette
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
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Chris Theriault
Chris Theriault
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
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Khaled Aldahmani
Khaled Aldahmani
Department of Medicine, Tawam Hospital in Affiliation with Johns Hopkins, AI Ain, UAE
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Syed Ali Imran
Syed Ali Imran
Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, Canada
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Introduction Sellar masses (SMs) are mostly benign growths of pituitary or non-pituitary origin that are increasingly encountered in clinical practice, accounting for approximately 14–18% of all brain tumours ( 1 , 2 ). SMs typically present
Malgorzata Fuksiewicz
Malgorzata Fuksiewicz
Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
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Maria Kowalska
Maria Kowalska
Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
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Agnieszka Kolasinska-Cwikla
Agnieszka Kolasinska-Cwikla
Department of Oncology and Radiotherapy, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
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Beata Kotowicz
Beata Kotowicz
Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
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the degree of brain damage, for example, in patients after cardiac arrest ( 1 , 2 ). Increased NSE concentrations are also observed in the course of neoplastic diseases. Increasing concentrations of the marker in patients with initially diagnosed
Serena Martinelli
Serena Martinelli
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
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Mario Maggi
Mario Maggi
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
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Elena Rapizzi
Elena Rapizzi
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
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Introduction In 2017, the World Health Organization (WHO) of Endocrine Tumours recognised anatomic criteria for PPGL classification ( 1 ). Pheochromocytomas (PCCs) are tumours originating from the neural crest-derived chromaffin cells within
