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Katherine Van Loon
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Li Zhang
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Jennifer Keiser
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Cendy Carrasco
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Katherine Glass The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA

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Maria-Teresa Ramirez The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA

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Sarah Bobiak The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA

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Eric K Nakakura
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Alan P Venook
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Manisha H Shah The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA

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Emily K Bergsland
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(2) . Historically, bone metastases from NETs were considered to be extremely rare (3, 4) . As few as 50 case reports were identified in a recently published literature review on skeletal metastases from carcinoid tumors (5) . In a series of 145

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Matteo Scopel Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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Eugenio De Carlo Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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Francesca Bergamo Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Sabina Murgioni Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Riccardo Carandina Radiodiagnostic Unit, University Hospital of Padua, Padua, Italy

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Anna Rita Cervino Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Marta Burei Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Federica Vianello Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Vittorina Zagonel Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Matteo Fassan Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Roberto Vettor Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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always been considered a rare and late event. To date, thanks to the improvement of therapies, which has lengthened the life expectancy of NET patients, and imaging techniques, in particular PET with 68 Ga-SSA, the amount of diagnosis of bone metastases

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Jiaxin Luo Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Weili Yin Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Qiuxia Lin The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China

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Juqing Wu Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Pan Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yuanna Ling Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Jing Wang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Zhen Li Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Liqin Pan Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Yanying Chen Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Wei Ouyang Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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Huijuan Feng Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China

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detection and appropriate treatment might improve the survival rate and quality of life of patients with DTC bone metastases ( 10 ). However, there is no standardized treatment regimen for these patients. At present, the main treatment modalities include

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Emma Jernberg Department of Medical biosciences, Umeå University, Umeå, Sweden

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Anders Bergh Department of Medical biosciences, Umeå University, Umeå, Sweden

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Pernilla Wikström Department of Medical biosciences, Umeå University, Umeå, Sweden

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-V/ARwt heterodimers form in parallel and have the potential to regulate different sets of target genes ( 75 ). AR-Vs may transcribe canonically androgen-regulated genes or a unique subset of genes or possibly both. In clinical bone metastases, we found high AR-V7

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Joana Simões-Pereira Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal

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Daniel Macedo Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal

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Maria João Bugalho Endocrinology Department, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal

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metastases (encephalic parenchyma involvement and/or leptomeningeal carcinomatosis) from this tumor were considered as inclusion criteria. Patients with coexisting malignant neoplasms and/or CNS involvement due to skull bone metastases were excluded from

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Kranti Khadilkar Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India

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Vijaya Sarathi Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Center, Bangalore, India

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Rajeev Kasaliwal Department of Endocrinology, Mahatma Gandhi Hospital and Medical College, Jaipur, India

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Reshma Pandit Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India

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Manjunath Goroshi Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India

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Gaurav Malhotra Radiation Medicine Centre, Bhabha Atomic Research Centre, Mumbai, India

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Abhay Dalvi Department of General Surgery, Seth G S Medical College and KEM Hospital, Mumbai, India

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Ganesh Bakshi Department of Uro-oncology, Tata Memorial Hospital, Mumbai, India

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Anil Bhansali Department of Endocrinology, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India

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Rajesh Rajput Department of Endocrinology, Pt. B.D. Sharma PGIMS, Rohtak, India

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Vyankatesh Shivane Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India

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Anurag Lila Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India

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Tushar Bandgar Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India

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Nalini S Shah Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, India

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developed metachronous metastases after a median follow-up period of 17.5 months (range: 12–48 months). Synchronous metastases were common in bones, lungs and liver, whereas in patients with metachronous metastases, apart from bones, lungs and liver, five

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Keiko Ohkuwa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiminori Sugino Department of Surgery, Ito Hospital, Tokyo, Japan

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Mitsuji Nagahama Department of Surgery, Ito Hospital, Tokyo, Japan

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Wataru Kitagawa Department of Surgery, Ito Hospital, Tokyo, Japan

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Kenichi Matsuzu Department of Surgery, Ito Hospital, Tokyo, Japan

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Akifumi Suzuki Department of Surgery, Ito Hospital, Tokyo, Japan

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Chisato Tomoda Department of Surgery, Ito Hospital, Tokyo, Japan

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Kiyomi Hames Department of Surgery, Ito Hospital, Tokyo, Japan

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Junko Akaishi Department of Surgery, Ito Hospital, Tokyo, Japan

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Chie Masaki Department of Surgery, Ito Hospital, Tokyo, Japan

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Koichi Ito Department of Surgery, Ito Hospital, Tokyo, Japan

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as bone metastases, appeared during the follow-up were not excluded, which might have affected the prognosis. Conclusion Among cases of lung metastases of differentiated thyroid carcinoma with RAI accumulation, those with high NLR at initial

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Athanasios D Anastasilakis Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece

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Marina Tsoli 1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Gregory Kaltsas 1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece

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Polyzois Makras Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, Athens, Greece

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successfully used as a therapeutic and preventive treatment strategy in management of patients with bone metastases from various tumors ( 62 ). Their beneficial effect in LCH bone lesions was first reported in 1989 when clodronate was used to treat multifocal

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Qian Wang Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Jiacheng Wang Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Yunhui Xin Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Ziyang He Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Xiang Zhou Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Xing Liu Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Teng Zhao Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Lihan He Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Hong Shen Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Mulan Jin Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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Bojun Wei Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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, alkaline phosphatase; F, female; iPTH, intact parathyroid hormone; M, male; OP, operation; Y, year. A total of 6 patients with PC had distant metastases, including the 4 cases with lung metastases, 1 with bone metastases, and 1 with liver and lung

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David T Broome Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Gauri B Gadre Department of Internal Medicine, Scripps Clinic, La Jolla, California, USA

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Ehsan Fayazzadeh Department of Radiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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James F Bena Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Christian Nasr Department of Endocrinology, Diabetes & Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio, USA

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Centrality of lung metastases unknown 4 (2.8) ---- 4 (7.5) 2 (4.7) 2 (20.0) 0.16 d Visible metastases in bone 0.37 c 0.060 c  Yes 32 (22.4) 18 (20.0) 14 (26.4) 9 (20.9) 5 (50.0)  No 111 (77.6) 72

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