Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center, Lundlaan, EA Utrecht, The Netherlands
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Introduction Endocrine complications are common in up to 60% of childhood cancer survivors (CCS) ( 1 ). Deprived bone health, ranging from low bone mineral density (BMD) to bone pain and fractures, is a prevalent late effect, and brain tumor
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dimorphic traits to develop. Especially pubertal bone mass accrual and adult bone health require further investigation in this context. Some studies in men who had constitutionally delayed puberty suggest that this condition resulted in reduced bone
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) and the natural fetal estrogen estetrol (E4) ( 24 , 25 ). In the present narrative review, we limited ourselves to report the observed effects of estrogens on bone health in patients with advanced PCa, taking potential estrogen side effects into
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Childhood cancer survivors are at increased risk of developing (long-term) skeletal adverse effects, such as osteonecrosis, impaired bone mineral density, and fractures. This paper provides an overview of the current understanding of bone health in these survivors, examining whether it represents a significant concern. It focuses on the challenges of assessing and managing bone health in childhood cancer survivors, highlighting diagnostic pitfalls, methods for accurately identifying those at high risk, and suggested strategies for surveillance and management of osteonecrosis and impaired bone mineral density. The need for improved surveillance strategies, particularly for high-risk survivors, alongside potential prevention and management options, including pharmacological and lifestyle interventions, is emphasised. Given the lack of consensus on optimal prevention and treatment strategies, the paper emphasises the need for further research to optimise care and improve long-term outcomes for childhood cancer survivors with bone health impairments.
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fragility fractures. Bone mineral density (BMD) Bone mineral density (BMD) estimated by dual X-ray absorptiometry (DXA) is commonly used to evaluate bone health and fracture risk. Given the good reliability and reproducibility, and low costs, BMD
Laboratory for Anthropology and Skeletal Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
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development of preventive and therapeutic strategies to combat one of the most common health problems in aged individuals worldwide. Role of osteocytes in bone adaptation Currently, many bone properties are considered to be controlled or mediated by
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Paediatric Neurosciences Research Group, Royal Hospital for Children, NHS Greater Glasgow & Clyde, Glasgow, UK
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strong link to bone health, and an assessment of BMA may be able to provide indirect information on osteoblast activity ( 6 ). Secondary osteoporosis is also encountered in people with reduced mobility and muscle deficits such as muscular dystrophies ( 7
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Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
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Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
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Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
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Department of Cardiology, Department of Research, Institute of Clinical Studies, Clinical Research Unit, Department of Paediatrics, Department of Medicine, Department of Physiology and Nuclear Medicine, Institute of Clinical Medicine, Nephrology and Endocrinology
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to improved endothelial function, inhibition of foam cell formation and suppression of macrophage cholesterol uptake in patients with T2D (19, 20) . Vitamin D's effect on bone health (fractures and bone mineral density (BMD)) is well established in
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Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
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, bleeding, ophthalmologic and hearing issues, mild developmental delay/intellectual disability, and a predisposition to malignancy ( 1 , 2 , 3 , 4 ). The presentation of symptoms varies among individuals, and the individual health impairment can range
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Jan van Goyen Medical Center, Department of Internal Medicine, Amsterdam, the Netherlands
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Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
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. These processes are regulated by hormonal changes and often lead to physical changes in the mother’s skeleton. In addition, lifestyle factors which have an impact on bone health can alter during pregnancy and lactation. Physical activity may be lower