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Keina Nishio, Akiko Tanabe, Risa Maruoka, Kiyoko Nakamura, Masaaki Takai, Tatsuharu Sekijima, Satoshi Tunetoh, Yoshito Terai and Masahide Ohmichi

samples as a bone formation marker. The reference range was 9.6 to 22.6 U/l. Bone resorption was assessed by measurements of the urinary amino-terminal telopeptide fragment of type I collagen (NTx) in the early morning using a second voided urine sample

Open access

Kaisa K Ivaska, Maikki K Heliövaara, Pertti Ebeling, Marco Bucci, Ville Huovinen, H Kalervo Väänänen, Pirjo Nuutila and Heikki A Koistinen

not observed previously. Clowes et al . (30) used a 2 h hyperinsulinemic euglycemic clamp with high insulin infusion rate (80 mU/m 2 per min) and reported no significant change in bone formation and resorption markers, which is in line with our 2 h

Open access

Stephen A Martin, Kenneth A Philbrick, Carmen P Wong, Dawn A Olson, Adam J Branscum, Donald B Jump, Charles K Marik, Jonathan M DenHerder, Jennifer L Sargent, Russell T Turner and Urszula T Iwaniec

, an interval during which the mice accrued cortical bone. Compared to standard room temperature housing (22°C), mice housed at thermoneutral conditions had increased bone formation and decreased bone resorption ( 2 ). Differences in thermoregulatory

Open access

Ann-Kristin Picke, Graeme Campbell, Nicola Napoli, Lorenz C Hofbauer and Martina Rauner

animals is associated with suppressed bone formation and with negative effects on the mechanosensing properties of osteocytes, while effects on bone resorption are less consistently described. In humans, biochemical markers and bone histomorphometry reveal

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Petar Milovanovic and Björn Busse

molecules), the sum of the stimuli determines whether osteocytes stimulate or inhibit bone formation or resorption ( 28 ). In the case of loading, increased fluid flow stimulates osteocytes to produce biochemical signals that inhibit osteoclast formation and

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Martine Cohen-Solal, Thomas Funck-Brentano and Pablo Ureña Torres

bone resorption and BSAP, sclerostin, and procollagen type 1 N-terminal propeptide (P1NP) for bone formation ( 36 ). A more recent study revealed that BSAP, P1NP and TRAP5b were highly correlated to the level of bone remodeling assessed by bone biopsies

Open access

Sylvia Thiele, Anke Hannemann, Maria Winzer, Ulrike Baschant, Heike Weidner, Matthias Nauck, Rajesh V Thakker, Martin Bornhäuser, Lorenz C Hofbauer and Martina Rauner

presented in x-fold increase relative to beta-actin. Analysis of sclerostin and bone formation and resorption markers in the serum and supernatant Pro-collagen type 1 N-terminal peptide (P1NP; IDS Immunodiagnostic Systems GmbH, Frankfurt am Main

Open access

Athanasios D Anastasilakis, Marina Tsoli, Gregory Kaltsas and Polyzois Makras

controlling osteoclastic bone resorption ( 32 ). RANK, RANKL and OPG are members of the TNF superfamily. Besides bone, RANK and RANKL are also expressed by various cells of the immune system, as RANKL is found on T and B cells and RANK on DCs, macrophages

Open access

Elena Valassi, Natalia García-Giralt, Jorge Malouf, Iris Crespo, Jaume Llauger, Adolfo Díez-Pérez and Susan M Webb

single-strand, non-coding RNAs that span between 19 and 24 nucleotide bases ( 10 ). These molecules are involved in the modulation of a wide variety of biological processes, including bone cell formation, bone remodeling, bone homeostasis and skeletal

Open access

Tingting Jia, Ya-nan Wang, Dongjiao Zhang and Xin Xu

reaction ( 10 ), then lead to function changes of osteoblasts and osteoclasts ( 11 , 12 ) and impair bone formation eventually. Moreover, David et al . argued that the formation of AGEs in high glycemic conditions, may contribute to a slower rate of