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Athanasios D Anastasilakis, Marina Tsoli, Gregory Kaltsas and Polyzois Makras

agents are often considered, especially when there is solely or predominantly skeletal involvement ( 37 , 60 ). Bisphosphonates are chemical analogs of pyrophosphates that inhibit osteoclast activity and reduce bone resorption ( 61 ). They have been

Open access

Petar Milovanovic and Björn Busse

). (Backscattered electron microscopy images, Scale bar 1 µm). Our backscattered electron microscopy data on femoral cortical bone in young females, healthy aged females, females with untreated osteoporosis, and females with bisphosphonate-treated (BP

Open access

Katherine Van Loon, Li Zhang, Jennifer Keiser, Cendy Carrasco, Katherine Glass, Maria-Teresa Ramirez, Sarah Bobiak, Eric K Nakakura, Alan P Venook, Manisha H Shah and Emily K Bergsland

form of bone-directed therapy: 50% received a form of radiation, 45% received a bisphosphonate, 18% underwent surgical resection, 13% received 131 I-MIBG, and 5% received denosumab. Moreover, 46% were treated with more than one treatment modality

Open access

Lu Liu, Chunyan Li, Peng Yang, Jian Zhu, Dongmei Gan, Le Bu, Manna Zhang, Chunjun Sheng, Hong Li and Shen Qu

occurs. Current medications used to treat osteoporosis include bisphosphonates, raloxifene, calcitonin, and hormone replacement therapy (2) . Bisphosphonates are a class of widely prescribed drugs that are proven to be effective in reducing common bone

Open access

Jennifer Walsh, Neil Gittoes, Peter Selby and the Society for Endocrinology Clinical Committee

develops; not effective for reducing serum calcium May need to consider dialysis if severe renal failure If further treatment required after intravenous saline, consider intravenous bisphosphonates Zoledronic acid 4 mg over 15 min OR

Open access

Marie Freel

the case of hypercalcaemia, the first step is rehydration with normal saline, and intravenous zoledronic acid is now the bisphosphonate of choice. Pituitary apoplexy ( 7 ): in this condition, recognition and prompt treatment with intravenous

Open access

Ranganathan R Rao, Harpal S Randeva, Sailesh Sankaranarayanan, Murthy Narashima, Matthias Möhlig, Hisham Mehanna and Martin O Weickert

patients in the non-responder/control group) were treated with bisphosphonates. Patients who received treatment with cinacalcet were not included in the analyses. None of the patients were treated with thiazide diuretics or other agents that are known to

Open access

Martine Cohen-Solal, Thomas Funck-Brentano and Pablo Ureña Torres

persistent kidney function. When eGFR is above 30 mL/mn, the main anti-fracture medications such as raloxifene, bisphosphonates and teriparatide (the human recombinant PTH) will follow the same recommendations as in non-CKD patients. Until recently, the

Open access

Kathrin R Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf and Marcus Quinkler

study enrolment (visit1), after 2 and 5 years (visit2 and visit3, respectively), BMD was assessed by DXA scan, and all clinical data, including hormone replacement therapies, DHEA and bisphosphonate therapies and changes were documented. Fracture

Open access

K Amrein, A Papinutti, E Mathew, G Vila and D Parekh

consideration of intravenous bisphosphonates which potently reduce bone resorption ( 47 ). However, a number of contraindications and potential side effects like hypocalcemia, renal impairment and atrial fibrillation need to be considered. In order to avoid