TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Sophia Children’s Hospital, Dr. Molewaterplein, Rotterdam, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Department of Clinical, Neuro, and Developmental Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat, Amsterdam, The Netherlands
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TRIXY Center of Expertise, Leiden University Treatment and Expertise Centre (LUBEC), Sandifortdreef, Leiden, The Netherlands
Leiden Institute for Brain and Cognition, Leiden University, Wassenaarseweg, Leiden, The Netherlands
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Introduction About 1 in 650–1000 children are born with a 47,XXY, 47,XXX, or 47,XYY chromosomal pattern, as a result of having an extra X or Y chromosome ( 1 ). Knowledge about the neurocognitive and behavioral phenotypes of these sex
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Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
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Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
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Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina, USA
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widespread human exposure ( 1 ). Previously, the most commonly used chemical FRs were mixtures of polybrominated diphenyl ethers (PBDEs). Due to toxicity concerns, including associations between PBDE exposure and behavioral and cognitive impairments in humans
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Department of Microbiology, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil
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biological behavior of NIFTP is similar to that of FTA and infiltrative FVPTC, on the other hand, tends to clinically behave more like the classical variant of PTC, with a higher incidence of cervical lymph node metastasis ( 1 , 17 , 18 , 23 , 24 , 25
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on the body to planned management behaviors to troubleshooting unplanned issues with devices. The need for constant interaction with the system can be emotionally taxing. Users have described devices as a physical reminder of having diabetes ( 19
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contribute to maintain body temperature including behavioral changes such as moving less in the heat or cuddling in the cold ( 1 ). In the past decade, a special research focus has been put on the mechanisms underlying heat generation, as these processes
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Department of Neuroscience, Georgetown University, Washington, District of Columbia, USA
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depressive disorders may be similar, as evidenced by overlapping symptoms (e.g., irritability, high negative affect) and treatments (e.g., selective serotonin reuptake inhibitors (SSRIs), cognitive behavioral therapy) ( 3 ). Depression and anxiety can be
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, USA
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA
Department of Physiology & Pharmacology, Oregon Health & Science University, Portland, Oregon, USA
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Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, USA
Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, USA
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included watching video programs and interactions with the Behavioral Science Unit staff and animal care technicians. Experimental design Approximately 6 weeks after the start of the WSD, all of the animals were OvH. Half ( n = 7) were immediately
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antihyperglycemic regimens in African Americans. The independent or the predictive variables for this study were attitude, subjective norms, perceived behavioral control and intention toward adherence to oral antihyperglycemic regimens. Intention was used as an
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Objective
Considering the plight in thyroid cancer therapy, we aimed to find novel therapeutic targets from a molecular perspective.
Methods
Quantitative real-time PCR (qRT-PCR) and Western blot assay were carried out to determine RNA and protein expression. Cell counting kit-8 (CCK8) assay, flow cytometry, transwell migration assay and aerobic glycolysis analysis were performed to analyze cell proliferation, apoptosis, migration and aerobic glycolysis of thyroid cancer cells. MiRcode and Starbase software were used to search the downstream genes of long noncoding RNA (lncRNA) deleted in lymphocytic leukemia 2 (DLEU2) and microRNA-205-5p (miR-205-5p), and the intermolecular combination was confirmed by dual-luciferase reporter assay. The in vivo role of DLEU2 in tumor growth was verified using the murine xenograft model.
Results
DLEU2 and tumor necrosis factor-α-induced protein 8 (TNFAIP8) were highly expressed in thyroid cancer tissues and cell lines. DLEU2 and TNRAIP8 promoted the proliferation, migration and aerobic glycolysis and restrained the apoptosis of thyroid cancer cells. DLEU2/miR-205-5p/TNFAIP8 signaling axis was identified in thyroid cancer cells. TNFAIP8 overexpression largely rescued the malignant phenotypes in DLEU2-silenced thyroid cancer cells. DLEU2 positively regulated TNFAIP8 expression by acting as miR-205-5p sponge in thyroid cancer cells. DLEU2 silencing blocked the growth of xenograft tumors in vivo.
Conclusion
lncRNA DLEU2 exerted a pro-tumor role to promote proliferation, migration and aerobic glycolysis while repressing the apoptosis of thyroid cancer cells via miR-205-5p/TNFAIP8 axis.
Leiden Institute for Brain and Cognition, Leiden, The Netherlands
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Leiden Institute for Brain and Cognition, Leiden, The Netherlands
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Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado
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Leiden Institute for Brain and Cognition, Leiden, The Netherlands
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, including behavioral, social, and cognitive problems, that can be present across the life span (for a review see ( 3 )). There is growing evidence that emotion regulation difficulties are also part of the daily challenges that may be experienced by the SCT
