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Sarah J Delforce
Sarah J Delforce
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Eugenie R Lumbers
Eugenie R Lumbers
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Celine Corbisier de Meaultsart
Celine Corbisier de Meaultsart
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Yu Wang
Yu Wang
Oregon Health and Science University, Portland, Oregon, USA
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Anthony Proietto
Anthony Proietto
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Geoffrey Otton
Geoffrey Otton
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Jim Scurry
Jim Scurry
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Nicole M Verrills
Nicole M Verrills
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, University of Newcastle, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Hunter Area Pathology Service, John Hunter Hospital, Newcastle, New South Wales, Australia
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Kirsty G Pringle
Kirsty G Pringle
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Priority Research Centre for Reproductive Sciences, University of Newcastle, Newcastle, New South Wales, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Ang I by angiotensin-converting enzyme (ACE), can act on the angiotensin II type 1 receptor (AGTR1) to stimulate angiogenesis and cell proliferation. There is also an additional RAS pathway that opposes the Ang II/AGTR1 pathway. This is the ACE2/Ang(1
Kirsty G Pringle
Kirsty G Pringle
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Sarah J Delforce
Sarah J Delforce
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Yu Wang
Yu Wang
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Katie A Ashton
Katie A Ashton
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Anthony Proietto
Anthony Proietto
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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Geoffrey Otton
Geoffrey Otton
Hunter Centre for Gynaecological Cancer, John Hunter Hospital, Newcastle, New South Wales, Australia
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C Caroline Blackwell
C Caroline Blackwell
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Division of Molecular Medicine, Pathology North, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
Division of Molecular Medicine, Pathology North, Newcastle, New South Wales, Australia
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Eugenie R Lumbers
Eugenie R Lumbers
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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Hunter Medical Research Institute, New Lambton, Newcastle, New South Wales, Australia
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the RAS which, via the angiotensin II type 1 receptor (AGTR1), stimulates angiogenesis and cell proliferation ( 4 , 5 , 6 ). In tissues, inactive prorenin is non-proteolytically activated by binding to the (pro)renin receptor (ATP6AP2), so it forms
Wioletta Pijacka
Wioletta Pijacka
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Morag G Hunter
Morag G Hunter
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Fiona Broughton Pipkin
Fiona Broughton Pipkin
School of Biosciences, New Maternity Unit, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK
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Martin R Luck
Martin R Luck
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Winther H Dantzer V Poulsen K . Dominance of type 1 angiotensin II receptor in the nonpregnant and pregnant bovine uterus . Journal of Reproduction and Fertility 1999 116 403 – 413 . ( doi:10.1530/jrf.0.1160403 ). 8 Wijayagunawardane MP
M L M Barreto-Chaves
M L M Barreto-Chaves
Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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N Senger
N Senger
Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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M R Fevereiro
M R Fevereiro
Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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A C Parletta
A C Parletta
Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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A P C Takano
A P C Takano
Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
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-(1–9), angiotensin-(1–9); Ang-(1–7), angiotensin-(1–7); ACE, angiotensin I converting enzyme; ACE2, angiotensin II converting enzyme; AT1R, angiotensin II receptor type 1; AT2R, angiotensin II receptor type 2. Although the RAS has been
Frans H H Leenen
Frans H H Leenen
Brain and Heart Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
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Mordecai P Blaustein
Mordecai P Blaustein
Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
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Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
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John M Hamlyn
John M Hamlyn
Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
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White R Chen A Ahmad M Leenen FHH. Mineralocorticoid and angiotensin II type 1 receptors in the subfornical organ mediate angiotensin II: induced hypothalamic reactive oxygen species and hypertension . Neuroscience 2016 329 112
Xue-Lian Zhang
Xue-Lian Zhang
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Xinyi Zhao
Xinyi Zhao
Department of Physiology, School of Medicine, Jinan University, Guangzhou, China
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Yong Wu
Yong Wu
Department of Physiology, School of Medicine, Jinan University, Guangzhou, China
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China
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Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China
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Wen-qing Huang
Wen-qing Huang
Department of Transfusion Medicine, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China
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Jun-jiang Chen
Jun-jiang Chen
Department of Physiology, School of Medicine, Jinan University, Guangzhou, China
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China
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Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China
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Peijie Hu
Peijie Hu
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China
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Wei Liu
Wei Liu
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Yi-Wen Chen
Yi-Wen Chen
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Jin Hao
Jin Hao
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Rong-Rong Xie
Rong-Rong Xie
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Hsiao Chang Chan
Hsiao Chang Chan
Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, China
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Ye Chun Ruan
Ye Chun Ruan
Department of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China
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Hui Chen
Hui Chen
Cell-Gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
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Jinghui Guo
Jinghui Guo
Department of Physiology, School of Medicine, Jinan University, Guangzhou, China
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( 3 ). RAS exerts its role through two arms with opposing functions. The pressor arm consists of renin, angiotensin-converting enzyme (ACE), angiotensin 2 and angiotensin type 1 receptor, which causes vasoconstriction. The other depressor arm consists
Janaína Felix Braga
Janaína Felix Braga
Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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Daniela Ravizzoni Dartora
Daniela Ravizzoni Dartora
Cardiology Institute of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil
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Natalia Alenina
Natalia Alenina
Max-Delbruck Center of Molecular Medicine (MDC), Berlin-Buch, Berlin, Germany
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Michael Bader
Michael Bader
Cardiology Institute of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil
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Robson Augusto Souza Santos
Robson Augusto Souza Santos
Department of Physiology and Biophysics, National Institute of Science and Technology in Nanobiopharmaceutics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Cardiology Institute of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil
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Cardiology Institute of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil
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. Alterations in gene expression in the testis of angiotensin-(1-7)-receptor Mas-deficient mice . Regulatory Peptides 2007 138 51 – 55 . ( doi:10.1016/j.regpep.2006.11.017 ) 7 Lazaroni TL Raslan AC Fontes WR de Oliveira ML Bader M Alenina N Moraes MF
Peter L Kristensen
Peter L Kristensen
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
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Ulrik Pedersen-Bjergaard
Ulrik Pedersen-Bjergaard
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Rikke Due-Andersen
Rikke Due-Andersen
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Lægerne på Ellemarksvej, Køge, Denmark
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Lægerne på Ellemarksvej, Køge, Denmark
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Thomas Høi-Hansen
Thomas Høi-Hansen
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Department of Cardiology, Herlev-Gentofte University Hospital, Herlev, Denmark
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Department of Cardiology, Herlev-Gentofte University Hospital, Herlev, Denmark
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Lise Grimmeshave
Lise Grimmeshave
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Novo Nordisk A/S, Søborg, Denmark
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Novo Nordisk A/S, Søborg, Denmark
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Valeriya Lyssenko
Valeriya Lyssenko
Steno Diabetes Center, Gentofte, Denmark
Lund University Diabetes Centre, Skåne University Hospital, Malmø, Sweden
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Lund University Diabetes Centre, Skåne University Hospital, Malmø, Sweden
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Leif Groop
Leif Groop
Lund University Diabetes Centre, Skåne University Hospital, Malmø, Sweden
Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland
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Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland
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Jens J Holst
Jens J Holst
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, The Panum Institute, Copenhagen, Denmark
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Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, The Panum Institute, Copenhagen, Denmark
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Allan A Vaag
Allan A Vaag
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Endocrinology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
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Department of Endocrinology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
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Birger Thorsteinsson
Birger Thorsteinsson
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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hypoglycaemia is largely unexplained. We previously speculated whether genetic factors are implicated and reported a high rate of severe hypoglycaemia in type 1 diabetic subjects carrying the common deletion-allele of the angiotensin-converting enzyme (ACE) gene
Dmitry M Davydov
Dmitry M Davydov
Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
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Malik K Nurbekov
Malik K Nurbekov
Laboratory of Sociogenomics, Moscow State Pedagogical University, Moscow, Russia
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levels were higher in D allele carriers of ACE ( DD & ID genotypes) compared with subjects with II genotype ( Table 4 ). Table 4 Main effects of polymorphisms of the dopamine D2 receptor ( DRD2/ANKK1 ), angiotensin 1 converting enzyme
Martin Wiegand
Martin Wiegand
MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK
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David J Halsall
David J Halsall
Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
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Sarah L Cowan
Sarah L Cowan
Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
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Kevin Taylor
Kevin Taylor
Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
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Robert J B Goudie
Robert J B Goudie
MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK
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Jacobus Preller
Jacobus Preller
Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
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Mark Gurnell
Mark Gurnell
Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Wellcome–MRC Institute of Metabolic Science, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK
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Wellcome–MRC Institute of Metabolic Science, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK
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activation by converting angiotensin II (AngII) to angiotensin 1–7 (Ang 1–7). Ang 1–7 exerts anti-inflammatory, anti-oxidative and vasodilatory effects via binding to the Mas receptor ( 4 ). AngII binds AngII receptor type 1 which then exerts pro
