Sarah Zaheer
Sarah Zaheer
Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, North Carolina, USA
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Kayla Meyer
Kayla Meyer
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, Massachusetts, USA
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Rebecca Easly
Rebecca Easly
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, Massachusetts, USA
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Omar Bayomy
Omar Bayomy
Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
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Janet Leung
Janet Leung
Section of Endocrinology, Virginia Mason Medical Center, Seattle, Washington, USA
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Andrew W Koefoed
Andrew W Koefoed
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, Massachusetts, USA
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Mahyar Heydarpour
Mahyar Heydarpour
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, Massachusetts, USA
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Roy Freeman
Roy Freeman
Harvard Medical School, Boston, Massachusetts, USA
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
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Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
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Gail K Adler
Gail K Adler
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
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Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
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–adrenal activation increase sclerostin. Therefore, the goal of this study was to determine if an infusion of cosyntropin (i.e. adrenocorticotropin hormone(1–24) (ACTH(1–24))), as compared to placebo, increases serum sclerostin levels in healthy men and women within
Giovanni Fanni
Giovanni Fanni
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Petros Katsogiannos
Petros Katsogiannos
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Bipasha Nandi Jui
Bipasha Nandi Jui
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Magnus Sundbom
Magnus Sundbom
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Susanne Hetty
Susanne Hetty
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Maria J Pereira
Maria J Pereira
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Jan W Eriksson
Jan W Eriksson
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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-effects models for differences in hormone levels or AUC OGTT across visits: * P < 0.05; ** P < 0.01; *** P < 0.001. N = 13 (except for glucagon, N = 7). ACTH, adrenocorticotropic hormone; GH, growth hormone; GLP-1, glucagon-like peptide 1; GIP, glucose
Boni Xiang
Boni Xiang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Ran Tao
Ran Tao
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Xinhua Liu
Xinhua Liu
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Xiaoming Zhu
Xiaoming Zhu
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Min He
Min He
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Zengyi Ma
Zengyi Ma
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
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Yehong Yang
Yehong Yang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Zhaoyun Zhang
Zhaoyun Zhang
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Yiming Li
Yiming Li
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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Zhenwei Yao
Zhenwei Yao
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China
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Yongfei Wang
Yongfei Wang
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
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Hongying Ye
Hongying Ye
Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China
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(ACTH)-dependent ( 1 ), and 20% is ACTH-independent. Pituitary corticotroph adenoma (Cushing’s disease (CD)) is the most common cause ( 2 ), followed by primary unilateral adrenal adenomas and ectopic adrenocorticotropic syndrome (EAS). The clinical
Nathalia G B P Ferreira
Nathalia G B P Ferreira
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Joao L O Madeira
Joao L O Madeira
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Peter Gergics
Peter Gergics
Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
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Renata Kertsz
Renata Kertsz
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Juliana M Marques
Juliana M Marques
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Nicholas S S Trigueiro
Nicholas S S Trigueiro
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Anna Flavia Figueredo Benedetti
Anna Flavia Figueredo Benedetti
University of Michigan Medical School, Department of Human Genetics, Ann Arbor, Michigan, United States
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Bruna V Azevedo
Bruna V Azevedo
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Bianca H V Fernandes
Bianca H V Fernandes
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
Universidade de São Paulo, Zebrafish Facility, São Paulo, São Paulo, Brazil
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Universidade de São Paulo, Zebrafish Facility, São Paulo, São Paulo, Brazil
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Debora D Bissegatto
Debora D Bissegatto
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Isabela P Biscotto
Isabela P Biscotto
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Qing Fang
Qing Fang
Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
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Qianyi Ma
Qianyi Ma
Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
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Asye B Ozel
Asye B Ozel
Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
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Jun Li
Jun Li
Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
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Sally A Camper
Sally A Camper
Laboratório de Sequenciamento em Larga Escala (SELA), Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil
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Alexander A L Jorge
Alexander A L Jorge
Unidade de Endocrinologia Genética, Laboratório de Endocrinologia Celular e Molecular LIM25, Disciplina de Endocrinologia da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Berenice B Mendonça
Berenice B Mendonça
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Ivo J P Arnhold
Ivo J P Arnhold
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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Luciani R Carvalho
Luciani R Carvalho
Unidade de Endocrinologia do Desenvolvimento, Laboratório de Hormônios e Genética Molecular LIM42, Disciplina de Endocrinologia, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil
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committee under the number CAAE 0642812.4.0000.0068 Proband A female patient was born from consanguineous parents and presented with CPHD (growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), prolactin (PRL
Janko Sattler
Janko Sattler
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Jinwen Tu
Jinwen Tu
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Shihani Stoner
Shihani Stoner
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
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Jingbao Li
Jingbao Li
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, China
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Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environmental Biophysics, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, China
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Frank Buttgereit
Frank Buttgereit
Department of Rheumatology and Clinical Immunology, Charité-University Medicine, Berlin, Germany
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Markus J Seibel
Markus J Seibel
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Hong Zhou
Hong Zhou
Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
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Mark S Cooper
Mark S Cooper
Adrenal Steroid Group, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia
Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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Concord Clinical School, The University of Sydney, Sydney, Australia
Department of Endocrinology & Metabolism, Concord Hospital, Sydney, Australia
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on a joint inflammation intensity scale from 0 to 12 points. Serum assays for corticosterone and adrenocorticotropic hormone Serum samples were collected at 12:00 h, before animals were killed and stored at −80°C until further examination
Jan W Eriksson
Jan W Eriksson
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Reem A Emad
Reem A Emad
Department of Pharmacy, Uppsala University, Uppsala, Sweden
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Martin H Lundqvist
Martin H Lundqvist
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Niclas Abrahamsson
Niclas Abrahamsson
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Maria C Kjellsson
Maria C Kjellsson
Department of Pharmacy, Uppsala University, Uppsala, Sweden
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(GH) ( 10 ). Cortisol secretion is primarily regulated by adrenocorticotropic hormone (ACTH), which, in turn, is stimulated by corticotrophin-releasing hormone (CRH) via the hypothalamic–pituitary–adrenal (HPA) axis. A major physiological effect of
Rachel Forfar
Rachel Forfar
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Mashal Hussain
Mashal Hussain
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Puneet Khurana
Puneet Khurana
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Jennifer Cook
Jennifer Cook
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Steve Lewis
Steve Lewis
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Dillon Popat
Dillon Popat
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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David Jackson
David Jackson
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Ed McIver
Ed McIver
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Jeff Jerman
Jeff Jerman
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Debra Taylor
Debra Taylor
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Adrian JL Clark
Adrian JL Clark
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Li F Chan
Li F Chan
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Introduction The melanocortins, comprising the α-, β-, and γ-melanocyte-stimulating hormones (MSHs) and adrenocorticotropic hormone (ACTH), are a family of peptide hormones cleaved from the prohormone pro-opiomelanocortin that have a diverse
Amit Kumar
Amit Kumar
Department of Medicine, Christian Medical College and Hospital, Ludhiana, Punjab, India
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Maria Ghosh
Maria Ghosh
Department of Biochemistry, Christian Medical College and Hospital, Ludhiana, Punjab, India
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Jubbin Jagan Jacob
Jubbin Jagan Jacob
Department of Endocrinology, Christian Medical College and Hospital, Ludhiana, Punjab, India
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tests and an Acton Prolongatum® (adrenocorticotropic hormone(1–34) (ACTH(1–34)) stimulation test (APST). Inclusion and exclusion criteria Adult patients (≥18 years) with EuVHNa who provided consent were included. Patients were considered to have
Fidéline Bonnet-Serrano
Fidéline Bonnet-Serrano
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Hormonology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Hormonology Department, Cochin Hospital, Paris, France
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Maxime Barat
Maxime Barat
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Radiology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Radiology Department, Cochin Hospital, Paris, France
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Anna Vaczlavik
Anna Vaczlavik
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Anne Jouinot
Anne Jouinot
Inserm U1016-CNRS UMR8104, Paris, France
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Lucas Bouys
Lucas Bouys
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Christelle Laguillier-Morizot
Christelle Laguillier-Morizot
Université Paris Cité, Paris, France
Hormonology Department, Cochin Hospital, Paris, France
INSERM, Physiopathologie et Pharmacotoxicologie Placentaire Humaine : Microbiote Pré & Post natal, Paris, France
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Hormonology Department, Cochin Hospital, Paris, France
INSERM, Physiopathologie et Pharmacotoxicologie Placentaire Humaine : Microbiote Pré & Post natal, Paris, France
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Corinne Zientek
Corinne Zientek
Hormonology Department, Cochin Hospital, Paris, France
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Catherine Simonneau
Catherine Simonneau
Hormonology Department, Cochin Hospital, Paris, France
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Etienne Larger
Etienne Larger
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Diabetology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Diabetology Department, Cochin Hospital, Paris, France
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Laurence Guignat
Laurence Guignat
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Lionel Groussin
Lionel Groussin
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Guillaume Assié
Guillaume Assié
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Jean Guibourdenche
Jean Guibourdenche
Université Paris Cité, Paris, France
Hormonology Department, Cochin Hospital, Paris, France
INSERM, Physiopathologie et Pharmacotoxicologie Placentaire Humaine : Microbiote Pré & Post natal, Paris, France
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Hormonology Department, Cochin Hospital, Paris, France
INSERM, Physiopathologie et Pharmacotoxicologie Placentaire Humaine : Microbiote Pré & Post natal, Paris, France
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Ioannis Nicolis
Ioannis Nicolis
Université Paris Cité, Paris, France
UR 7537 BioSTM, Paris, France
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UR 7537 BioSTM, Paris, France
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Marie-Claude Menet
Marie-Claude Menet
Institut de Chimie Physique, Université Paris-Saclay-CNRS, UMR8000, Orsay, France
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Jérôme Bertherat
Jérôme Bertherat
Université Paris Cité, Paris, France
Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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Inserm U1016-CNRS UMR8104, Paris, France
Reference Center for Rare Adrenal Diseases, Endocrinology Department, Cochin Hospital, Paris, France
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G-protein coupled membrane receptors, responsible for a cortisol response to non-physiological stimuli ( 8 , 9 , 10 ). The second one is the secretion of an ectopic intra-adrenal adrenocorticotropic hormone (ACTH) by clusters of adrenocortical
Izabelle Lövgren
Izabelle Lövgren
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
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Azadeh Abravan
Azadeh Abravan
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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Abigail Bryce-Atkinson
Abigail Bryce-Atkinson
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
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Marcel van Herk
Marcel van Herk
Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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small-cell lung carcinoma ( 5 ). However, cranial irradiation has previously been identified as a risk factor for endocrinopathy. Radiation damage to the hypothalamus and pituitary gland, which orchestrate hormone release from within the brain, can lead
