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Nicola Tufton, Lucy Shapiro, Anju Sahdev, Ajith V Kumar, Lee Martin, William M Drake, Scott A Akker and Helen L Storr

recent new information regarding the risks of radiation exposure in young patients ( 10 ). Paediatric index cases were diagnosed with a PCC or PGL in childhood or adolescence (aged <20 years) between 1975 and 2011. Index cases presented to their local

Open access

Karolien Van De Maele, Jean De Schepper, Jesse Vanbesien, Monique Van Helvoirt, Ann De Guchtenaere and Inge Gies


Vitamin D deficiency is common in obese adolescents and a risk factor for insulin resistance. We investigated if prevailing serum 25-OH vitamin D might predict the body fat loss in a group of obese adolescents undergoing a residential weight loss program.


In 92 (35 male) obese adolescents (aged 10.6–19 years) undergoing a residential weight loss program in Belgium, fasting serum 25-OH vitamin D (25-OH-D), insulin, glucose and lipid levels were measured and body composition was assessed by dual-energy X-ray absorptiometry (DXA).


Baseline median (range) serum 25-OH-D level was 17.7 µg/L (3.8–41.8). In total, 55 adolescents had a serum 25-OH-D below 20 µg/L. In 31 adolescents with a low baseline 25-OH-D level, median increase in serum 25-OH-D was 2.4 µg/L (−4.2 to 7.2) after 10 months. This resulted in normal 25-OH-D levels in seven adolescents, whereas median BMI decreased with 1.0 SDS and body fat percentage diminished with 9.9%. Obese adolescents with or without a 25-OH-D level below or above 20 µg/L at baseline had similar changes in body weight, BMI SDS, body fat percentage and body fat mass at the end of the program. The change in serum 25-OH-D did not correlate with change in serum insulin, BMI SDS or body fat percentage and body fat mass.


Vitamin D deficiency was present in 55 out of 92 obese adolescents at the start of the summer. Serum 25-OH-D concentration did not predict changes in body fat loss after a residential weight loss program.

Open access

Anita Hokken-Koelega, Aart-Jan van der Lely, Berthold Hauffa, Gabriele Häusler, Gudmundur Johannsson, Mohamad Maghnie, Jesús Argente, Jean DeSchepper, Helena Gleeson, John W Gregory, Charlotte Höybye, Fahrettin Keleştimur, Anton Luger, Hermann L Müller, Sebastian Neggers, Vera Popovic-Brkic, Eleonora Porcu, Lars Sävendahl, Stephen Shalet, Bessie Spiliotis and Maithé Tauber

Introduction Monumental changes in human development occur during adolescence. Teens undergo a period of physical growth and sexual maturation, and pronounced cognitive development, and are eagerly forming their own identities to achieve

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Kaiyu Pan, Chengyue Zhang, Xiaocong Yao and Zhongxin Zhu

Introduction Calcium (Ca) is the primary nutrient of interest in bone health. It is essential to ensure adequate Ca intake to support the accelerated growth spurt during childhood and adolescence when bone accumulates and grows at a rapid rate

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Andrew R Dismukes, Vanessa J Meyer, Elizabeth A Shirtcliff, Katherine P Theall, Kyle C Esteves and Stacy S Drury

models, TL attrition is likely linked to longevity; longer telomeres measured early in life have been linked to longer lifespans ( 16 ). Adolescence, TL, and DHEA Although childhood is not typically considered a developmental time period in which

Open access

Caroline Culen, Diana-Alexandra Ertl, Katharina Schubert, Lisa Bartha-Doering and Gabriele Haeusler

Adolescence 13–17 – Achieving a masculine or feminine social role – Accepting one’s physique and using the body effectively – Achieving new and more mature relations with age mates of both sex – Achieving emotional independence of parents and other adults

Open access

Farzaneh Rohani, Mohammad Reza Alai, Sedighe Moradi and Davoud Amirkashani

have a slow pattern of growth during childhood and adolescence. The patients are identified with short stature, delay bone age and puberty. Their bone age lags behind their chronological age, which is providing an indication of remaining the growth

Open access

A C Paepegaey, M Coupaye, A Jaziri, F Ménesguen, B Dubern, M Polak, J M Oppert, M Tauber, G Pinto and C Poitou

with PWS from adolescence to adult life is challenging for medical care because of multiple comorbidities, behavioral problems, specific skills required of the medical team and lack of an established scheme for the change from pediatric to adult medical

Open access

M Ahmid, C G Perry, S F Ahmed and M G Shaikh

Introduction Growth hormone deficiency (GHD) is an endocrine condition that can potentially impact on an individual’s life from childhood, adolescence to young adulthood and beyond. In UK, the prevalence of congenital childhood-onset GHD (CO

Open access

Giorgio Radetti, Mariacarolina Salerno, Chiara Guzzetti, Marco Cappa, Andrea Corrias, Alessandra Cassio, Graziano Cesaretti, Roberto Gastaldi, Mario Rotondi, Fiorenzo Lupi, Antonio Fanolla, Giovanna Weber and Sandro Loche

.1089/105072501750159651 ) 4 Monzani A Prodam F Rapa A Moia S Agarla V Bellone S Bona G. Endocrine disorders in childhood and adolescence. Natural history of subclinical hypothyroidism in children and adolescents and potential effects of replacement