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Erika Peverelli, Federica Ermetici, Sabrina Corbetta, Ettore Gozzini, Laura Avagliano, Marco A Zappa, Gaetano Bulfamante, Paolo Beck-Peccoz, Anna Spada and Giovanna Mantovani

Introduction White adipose tissue (WAT) is mainly involved in energy storage and mobilization in the form of triglycerides, although a paracrine and endocrine function of white adipocytes has also been recognized. Excess of WAT results from an

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Meena Asmar, Ali Asmar, Lene Simonsen, Flemming Dela, Jens Juul Holst and Jens Bülow

be elucidated. In the postprandial state, the adipose tissue’s metabolic role is primarily to deposit circulating triglycerides ( 1 ). As the enzyme LPL is bound to the adipose tissue capillaries, the capillary recruitment, that is enlarged vascular

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Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz and Marek Strączkowski

catalyzed by the enzyme adipose triglyceride lipase (ATGL), encoded by PNPLA2 . Diacylglycerol is further hydrolyzed to monoacylglycerol and fatty acid with hormone-sensitive lipase (HSL), encoded by LIPE , and monoacylglycerol is ultimately hydrolyzed to

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Julie Smith, Jan Fahrenkrug, Henrik L Jørgensen, Christina Christoffersen and Jens P Goetze

peri-renal white adipose tissue compared to corresponding measurements of serum lipids as independent variables. Time Gene Triglycerides Free fatty acids Glycerol ZT NPR-A NS P =0.01, r =0.36 NS

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Florian W Kiefer

-1651 ) 63 Blondin DP Frisch F Phoenix S Guerin B Turcotte EE Haman F Richard D Carpentier AC . Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering

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Renea A Taylor, Jennifer Lo, Natasha Ascui and Matthew J Watt

acids derived from the systemic circulation and the resident peri-prostatic adipose tissue are transported into the prostate epithelial cell where they undergo several fates including (1) oxidation in the mitochondria, (2) bulk storage as triglycerides

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Leanne Hodson and Fredrik Karpe

lipase (LPL), which is upregulated by insulin. Although the majority of liberated fatty acids are taken up by adipose tissue, some escape uptake and appear in the systemic plasma NEFA pool. These fatty acids are often referred to as spillover NEFA and may

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Nikolaj Rittig, Mads Svart, Niels Jessen, Niels Møller, Holger J Møller and Henning Grønbæk

epinephrine) stimulate lipolysis through the actions of adipose triglyceride lipase and hormone-sensitive lipase (HSL), which are rate-limiting enzymes in the conversion of triglycerides into glycerol and FFA. Increased rates of lipolysis elevate circulating

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Peter Wolf, Yvonne Winhofer, Martin Krššák and Michael Krebs

dysfunction and dysregulation of gene expression ( 20 ). Animal models impressively demonstrate the importance of a well-balanced interplay between lipid storage and lipolysis in cardiomyocytes, since mice lacking adipose triglyceride lipase (ATGL) develop

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Sandrine Visentin, Gérard Michel, Claire Oudin, Béatrice Cousin, Bénédicte Gaborit, Inès Abdesselam, Marie Maraninchi, Marion Nowicki, René Valéro, Maxime Guye, Monique Bernard, Pascal Auquier, Hervé Chambost, Marie-Christine Alessi and Sophie Béliard

with significantly more pronounced insulin resistance parameters (higher triglycerides, higher plasma glucose levels and lower HDL-C levels) despite lower BMIs and lower waist circumferences when compared to controls ( 15 ). MS is the clinico