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Introduction Individual patient attitudes and intentions can influence adherence to the use of medical therapies. ‘Adherence to the use of medical therapy’ has been defined as the level of participation expected of an individual who has agreed
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, and daily subcutaneous injections may present a significant burden ( 6 ). Poor adherence to the injection regimen is a major concern in the management of growth disorders, and regular assessment of adherence is an essential component of successful
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periods of time ( 7 ). Some studies have suggested that non-adherence to treatment occurs in a variable percentage of subjects ( 8 , 9 , 10 ). The main cause for minor efficacy in r-hGH therapy is the lack of adherence to treatment or non
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Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
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supplementation policies across Europe even for the existing population. We aimed to explore the differences in vitamin D policies and the factors relating to policy implementation that influence adherence rates. Methods A questionnaire with 20 questions
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assessment of treatment adherence, an important factor that is also frequently neglected in randomized controlled trials ( 28 , 29 ). As a result, there is still a significant unmet clinical need to develop strategies that are able to facilitate the accurate
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Pediatric team of the Clinical Investigation Center 9302/INSERM, Hospital of Children, Toulouse, France
Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), INSERM UMR1291 - CNRS UMR5051 - Université Toulouse III, Toulouse, France
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Patient-Reported Outcomes Unit (PROQOL), UMR 1123, University Paris Cité, INSERM, Paris, France
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improvement of psychosocial problems ( 3 , 4 ) and improvement in quality of life (QOL) ( 5 , 6 ). In addition, rhGH injections are well tolerated ( 7 , 8 ) even if adherence to treatment was shown as suboptimal ( 9 ). The majority of currently available
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Faculty of Nursing Science, Laval University, Québec City, Canada
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Endocrinology, Diabetes & Metabolism Service of the Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
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comparison with particular patient populations of interest (i.e. women with infertility and men with CHH and patients with rare endocrine disorders and chronic conditions). The Morisky Medication Adherence Scale (MMAS) is an 8-item instrument that assesses
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Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
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management warrant careful scrutiny. Conventional DM therapies face challenges, including enhancing medication adherence and improving patient prognosis, which necessitate resolution. Poor adherence to medication for primary chronic diseases can lead to
Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, INSERM, UMRS1138, Paris, France
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Université Paris-Saclay, Inserm U1185, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Service d’Endocrinologie et Diabète de l’Enfant, Centre de Référence des Maladies Rares du Calcium et du Phosphore et Filière de Santé Maladies Rares OSCAR, Hôpital Bicêtre Paris Saclay, Le Kremlin-Bicêtre, France
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Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Assistance Publique-Hôpitaux de Paris, Institut Necker-Enfants Malades, INSERM U1151 – CNRS UMR 8253, Paris, France
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Association Francophone de Chirurgie Endocrinienne (AFCE), France
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Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Biochimie et Génétique Moléculaires, Paris, France
INSERM, U1169, Université Paris Sud, Hôpital Bicêtre, Le Kremlin Bicêtre, France
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INSERM, U1418, CIC-EC, Hôpital Européen Georges Pompidou, Paris, France
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Centre de Référence des Maladies Rares du Calcium et du Phosphore Filière de Santé Maladies Rares OSCAR, Paris, France
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, INSERM, UMRS1138, Paris, France
CNRS, ERL8228, Paris, France
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of Ca salt and active vitamin D could be related either to milder cases or to lower adherence to guidelines. Depending on the criteria, the adherence to international guidelines ( 4 , 5 , 7 ) could be graded differently: ‘high’ if we were to
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provocative testing. IGF-I and IGFBP-3 measurements can inform the clinician about adherence to GH treatment and, if maintained at <+2 SDS, will generally avoid GH over-dosage. As explained above, multiple factors can influence serum IGF-I and IGFBP-3