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Introduction Ghrelin is a major regulator of food intake, energy balance and body weight ( 1 ). The active form of ghrelin, acyl-ghrelin, is the endogenous ligand for the growth hormone secretagogue receptor (GHSR)1a ( 2 ). Since its cloning
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Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes . Peptides 2011 32 2191 – 2 2 07 . ( https://doi.org/10.1016/j.peptides.2011.09.006 ) 9 Kageyama H kitamura Y Hosono T
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state by ghrelin O-acetyltransferase, ghrelin is divided into acyl ghrelin and des-acyl ghrelin. The ratio of two is 1:10 in plasma and 2:1 in the stomach ( 2 ). In adults, ghrelin is mainly produced by gastrointestinal endocrine cells ( 1 ). In addition
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.01.017 ) 9 Delhanty PJ Neggers SJ van der Lely AJ Mechanisms in endocrinology: Ghrelin: the differences between acyl- and des-acyl ghrelin . European Journal of Endocrinology 2012 167 601 – 608 . ( doi:10.1530/EJE-12
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
Medical Research Laboratories, Department of Endocrinology and Diabetes, Department of Pediatrics, Department of Endocrinology and Diabetes, Institute of Clinical Medicine, Aarhus University, Norrebrogade 44, DK-8000 Aarhus C, Denmark
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in the antecubital region for infusions and one was placed in a contralateral dorsal hand vein for arterialized blood sampling. Preparation of synthetic ghrelin: synthetic human acyl ghrelin (NeoMPS, Strasbourg, France) was dissolved in isotonic
Adelaide Medical School, The University of Adelaide, Adelaide, Australia
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reduction in adult weight of 40–45% ( 38 ). Loss of total or acyl-ghrelin also reduces GH secretion in mice, albeit to a lesser extent ( 39 , 40 ). Intriguingly, litter size is more than halved in homozygous females lacking GHRH, and neonatal mortality is
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.04.018 ) 10.1016/j.appet.2013.04.018 23624293 35 Stengel A Goebel M Wang L Taché Y . Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight . Peptides 2010 31 357 – 369
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://doi.org/10.1210/er.2006-0001 ) 54 Delhanty PJ Neggers SJ van der Lely AJ . Des-acyl ghrelin: a metabolically active peptide . Endocrine Development 2013 25 . ( https://doi.org/10.1159/000346059 ) 23652397 55 Cassoni P Allia E Marrocco T
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anterior pituitary hormones in healthy volunteers . Pituitary 2021 24 555 – 563 . ( https://doi.org/10.1007/s11102-021-01132-9 ) 48 Vestergaard ET Møller N Andersen RF Rittig S & Jørgensen JOL . Acute intravenous acyl ghrelin infusion