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June Young Choi, Jin Wook Yi, Jun Hyup Lee, Ra-Yeong Song, Hyeongwon Yu, Hyungju Kwon, Young Jun Chai, Su-jin Kim and Kyu Eun Lee

epidemiological reports show that higher levels of vitamin D3 are associated with a lower risk of developing cancer ( 3 ). The active form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25D) exerts antitumor activity by binding to the vitamin D receptor ( VDR ). The

Open access

Ozlem Atan Sahin, Damla Goksen, Aysel Ozpinar, Muhittin Serdar and Huseyin Onay

Introduction Type 1 diabetes (DM1) is a complex disease characterized by the autoimmune destruction of pancreatic β cells. Vitamin D is an immune regulatory hormone that exerts its effects through highly polymorphic VDR that belongs to

Open access

Melissa Braga, Zena Simmons, Keith C Norris, Monica G Ferrini and Jorge N Artaza

level there is also evidence of VDR expression and direct effects of vitamin D on human skeletal muscle precursor cells ( 7 ), which provides a rationale for a direct role of vitamin D in muscle function. Furthermore, mice lacking VDR show an abnormal

Open access

Amarjit Saini, Linda Björkhem-Bergman, Johan Boström, Mats Lilja, Michael Melin, Karl Olsson, Lena Ekström, Peter Bergman, Mikael Altun, Eric Rullman and Thomas Gustafsson

receptor (VDR). A heterodimer, formed with retinoid X receptor (RXR), then binds specific genomic sequences (vitamin D response elements or VDREs) acting to influence gene transcription ( 13 ). VDREs have been found in several hundred genes that are

Open access

Bingbing Wang, Mayra Cruz Ithier, Nataliya Parobchak, Stacy M Yadava, Jay Schulkin and Todd Rosen

occurs via two pathways: non-genomic and genomic responses, both of which involve binding of 1,25-dihydroxyvitamin D (1,25(OH)2D), the active metabolite of vitamin D and the vitamin D receptor (VDR), a member of the superfamily of nuclear receptor for

Open access

Yao Chen and Shu-ying Fang

-stimulating hormone receptor ( FSHR ) gene polymorphisms, fat mass and obesity-associated ( FTO ) gene polymorphisms, insulin receptor ( IR ) and IR substrate ( IRS ) polymorphisms, vitamin D receptor ( VDR ) polymorphisms, methylenetetrahydrofolate reductase ( MTHFR

Open access

Mirjam M Oosterwerff, Rosa Meijnen, Natasja M Van Schoor, Dirk L Knol, Mark H H Kramer, Mireille N M Van Poppel, Paul Lips and E Marelise W Eekhoff

-deficient patients. The presence of the vitamin D receptor (VDR) has been detected in mice by various techniques (32, 33, 34) . Bischoff et al . (35) were the first to report the detection of the VDR in human muscle cells. A recent study, however, did not find

Open access

Changwei Liu, Jingwen Wang, Yuanyuan Wan, Xiaona Xia, Jian Pan, Wei Gu and Mei Li

active form of 1,25(OH)2D3 binds to vitamin D receptors (VDR), which is like other steroid hormones to a nuclear hormone receptor. VDR is a member of the nuclear transcription factor superfamily and is detected in most tissues. Through activation by 1

Open access

J A Tamblyn, C Jenkinson, D P Larner, M Hewison and M D Kilby

-hydroxylase (24-hydroxylase) and the vitamin D receptor (VDR) ( 18 , 19 ). In uncomplicated pregnancy, significant changes in vitamin D physiology arise, with a surge in maternal serum 1,25(OH) 2 D3 from the first trimester ( 20 ). During pregnancy 1,25(OH) 2

Open access

Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara Obermayer-Pietsch and Elisabeth Lerchbaum

vitamin D receptor (VDR) can be found across several tissues within the female reproductive system. VDR mRNA is expressed in ovarian, deciduae, placenta and endometrium cells ( 6 , 23 , 24 ). Furthermore, calcitriol (1,25[OH] 2 vitamin D) directly leads