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Xianghe Chen College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China

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Xinyu Zeng College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China

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Xiao Qiu College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China

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Chi Liu College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China

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Pengcheng Lu College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China

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Ziming Shen College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China

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Xiangxiang Zhou College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China

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Kang Yang Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China

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renal anti-fibrosis and inflammatory response through the protein effect of nicotinamide adenine dinucleotide+ (NAD+) coenzyme ( 3 , 4 ). Some studies found that the downregulation of Sirt1 expression in T2DM kidney led to renal interstitial fibrosis

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0448
Volume/Issue:
Volume 13: Issue 3
Open access
Tingting Jia Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China

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Ya-nan Wang Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China

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Dongjiao Zhang Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China

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Xin Xu Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China
Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China

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osseointegration, which is critical for implanting, and increase the failure rate, type 2 diabetes mellitus (T2DM) is one of them ( 1 , 2 ). The pathological changes of T2DM, such as microangiopathy, immunity decline and collagen degradation, can reduce the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0241
Volume/Issue:
Volume 7: Issue 11
Open access
Marie Reeberg Sass Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Nicolai Jacob Wewer Albrechtsen Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark

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Jens Pedersen Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Endocrinology and Nephrology, Nordsjællands University Hospital, Hillerød, Denmark

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Kristine Juul Hare Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Nis Borbye-Lorenzen Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institute, Copenhagen, Denmark

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Katalin Kiss Department of Pathology, Rigshospitalet, Copenhagen, Denmark

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Tina Vilsbøll Steno Diabetes Center Copenhagen, Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Filip Krag Knop Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Steen Seier Poulsen Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Niklas Rye Jørgensen Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jens Juul Holst Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Cathrine Ørskov Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Bolette Hartmann Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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with mean and s.d. For panel B, *represent statistical significant difference using an unpaired t -test, whereas for panel D, *represent statistical significant difference using a paired-test. Data are illustrated as mean ±  s.e.m. n  = 9/8 (T1DM

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0092
Volume/Issue:
Volume 9: Issue 7
Open access
Changwei Liu Children’s Hospital of Nanjing Medical University, Nanjing, China

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Jingwen Wang Children’s Hospital of Nanjing Medical University, Nanjing, China

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Yuanyuan Wan Children’s Hospital of Nanjing Medical University, Nanjing, China

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Xiaona Xia Children’s Hospital of Nanjing Medical University, Nanjing, China

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Jian Pan Children’s Hospital of Nanjing Medical University, Nanjing, China

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Wei Gu Children’s Hospital of Nanjing Medical University, Nanjing, China

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Mei Li Children’s Hospital of Nanjing Medical University, Nanjing, China

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Background Type 1 diabetes mellitus (T1DM) is an autoimmune disease occurring in the pancreatic islets. The disease can affect people of any age, but onset usually occurs in children or young adults, which accounts for 90% of diabetes in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0191
Volume/Issue:
Volume 7: Issue 12
Open access
Xinge Tao Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China

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Yanbin Xue Computer Net Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Rui Niu Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China

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Wenjing Lu Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China

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Huayan Yao Computer Net Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Chunmei He Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China

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Bin Cui Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Changqin Liu Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
Xiamen Key Laboratory for Clinical Efficacy and Evidence-Based Research of Traditional Chinese Medicine, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China
Fujian Province Key Laboratory of Diabetes Translational Medicine, The First Affiliated Hospital of Xiamen University, School of medicine, Xiamen University, Xiamen, China

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substantial health burden, especially on developing countries. According to the diabetes atlas of the International Diabetes Federation in 2022, China had the largest number of patients with T2DM and spent the second highest amount on diabetes ( 1 ). The

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0474
Volume/Issue:
Volume 13: Issue 2
Open access
Borros Arneth Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Hospital of the Universities of Giessen and Marburg, UKGM, Justus Liebig University, Giessen, Giessen, Germany

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Introduction Type 1 diabetes mellitus (DM) is an autoimmune disease in which T-lymphocytes attack insulin-producing beta cells in the pancreas ( 1 ). During the later stages of this progressive disease, pancreatic beta cells are massively

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0230
Volume/Issue:
Volume 6: Issue 8
Open access
Li Qian Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Yuxiao Zhu Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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Yan Luo Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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Mu Zhang Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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Liping Yu Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Yu Liu Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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Tao Yang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Introduction Type 1 diabetes mellitus (T1DM) is well-defined as one of the most common and lifelong autoimmune diseases characterized by pancreatic β-cell destruction ( 1 , 2 ). Several autoantibodies, such as glutamic acid decarboxylase

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0325
Volume/Issue:
Volume 11: Issue 12
Open access
Karim Gariani Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland

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Pedro Marques-Vidal Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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Gérard Waeber Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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Peter Vollenweider Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland

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Introduction Type 2 diabetes mellitus (T2DM) pathogenesis may involve the hypothalamic–pituitary–adrenal axis (HPA) ( 1 ). Common features observed in T2DM and metabolic syndrome, such as elevated fasting glucose, obesity, hyperlipidemia or

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0251
Volume/Issue:
Volume 8: Issue 7
Open access
E R Polina Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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F M Oliveira Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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R C Sbruzzi Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil

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D Crispim Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

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L H Canani Endocrine Division, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil
Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil

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K G Santos Laboratory of Human Molecular Genetics, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil
Cardiovascular Research Laboratory, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil

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-MIR155 gene was recently associated with type 1 diabetes (T1DM) ( 22 ) and type 2 diabetes (T2DM) ( 23 ). However, its possible association with DR has not yet been investigated. Therefore, this study was designed to investigate whether the rs767649

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0446
Volume/Issue:
Volume 8: Issue 12
Open access
Xiuzhen Zhang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Dan Xu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Ping Xu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Shufen Yang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Qingmei Zhang Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Yan Wu Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Fengyi Yuan Department of Endocrinology and Metabolism, Shenzhen People’s hospital, The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China

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Introduction Amongst the background of the rising incidence of type 1 diabetes mellitus (T1DM) across the globe, public concern has reached a new high ( 1 ). Despite progress in diabetes care, as the leading cause of mortality in T1DM ( 2

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0146
Volume/Issue:
Volume 10: Issue 9
Open access