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Yiqiang Huang, Lin-ang Wang, Qiubo Xie, Jian Pang, Luofu Wang, Yuting Yi, Jun Zhang, Yao Zhang, Rongrong Chen, Weihua Lan, Dianzheng Zhang and Jun Jiang

subunit C) and SDHD and two catalytic subunits SDHA (succinate dehydrogenase complex flavoprotein subunit A) and SDHB. SDHB , an eight-exon gene localized on chromosome 1p36.13 and part of the mitochondrial electron transport complex II, is the most

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Nicola Tufton, Lucy Shapiro, Anju Sahdev, Ajith V Kumar, Lee Martin, William M Drake, Scott A Akker and Helen L Storr

–80%). Therefore, it is recommended that all children and adolescents presenting with PPGL should be offered genetic testing ( 3 , 4 ). The most commonly associated genes in children presenting with PPGL (aged ≤21 years) are VHL (38%), followed by SDHB (25

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Joakim Crona, Alberto Delgado Verdugo, Dan Granberg, Staffan Welin, Peter Stålberg, Per Hellman and Peyman Björklund

susceptibility genes: SDHA , SDHB , SDHC , SDHD , SDHAF2 , VHL , HIF2A ( EPAS1 ), RET , NF1 , TMEM127 and MAX (5, 6, 7, 8, 9, 10, 11) . While there has been a constant flow of reported new susceptibility loci, the capacity of instruments approved

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Kranti Khadilkar, Vijaya Sarathi, Rajeev Kasaliwal, Reshma Pandit, Manjunath Goroshi, Gaurav Malhotra, Abhay Dalvi, Ganesh Bakshi, Anil Bhansali, Rajesh Rajput, Vyankatesh Shivane, Anurag Lila, Tushar Bandgar and Nalini S Shah

population studies have suggested SDHB germline mutations as an important genetic predictor for metastasis, aggressiveness and poor outcome ( 15 ). Histopathologic features like PASS score and Ki67 have also been suggested to predict malignancy ( 14 , 16

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Natalie Rogowski-Lehmann, Aikaterini Geroula, Aleksander Prejbisz, Henri J L M Timmers, Felix Megerle, Mercedes Robledo, Martin Fassnacht, Stephanie M J Fliedner, Martin Reincke, Anthony Stell, Andrzej Januszewicz, Jacques W M Lenders, Graeme Eisenhofer and Felix Beuschlein

.2–37.8) iPPGL vs fPPGL 0.74 sPPGL vs fPPGL 0.19 iPPGL vs sPPGL 0.28 Mutations in susceptibility genes, n (%) 12/74 (16.2) 17/79 (21.5) 39/64 (60.9) iPPGL vs fPPGL <0.001 sPPGL vs fPPGL <0.001 iPPGL vs sPPGL 0.41   SDHA , n (%)   SDHB , n

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Qiuli Liu, Gang Yuan, Dali Tong, Gaolei Liu, Yuting Yi, Jun Zhang, Yao Zhang, Lin-ang Wang, Luofu Wang, Dianzheng Zhang, Rongrong Chen, Yanfang Guan, Xin Yi, Weihua Lan and Jun Jiang

mutations in the following susceptibility genes of Pheos and/or RCC: SDHAF2 (succinate dehydrogenase complex assembly factor 2), SDHB (succinate dehydrogenase subunit B), SDHC (succinate dehydrogenase subunit C), SDHD (succinate dehydrogenase subunit