Erika Peverelli
Erika Peverelli
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Federica Ermetici
Federica Ermetici
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Sabrina Corbetta
Sabrina Corbetta
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Ettore Gozzini
Ettore Gozzini
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Laura Avagliano
Laura Avagliano
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Marco A Zappa
Marco A Zappa
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Gaetano Bulfamante
Gaetano Bulfamante
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Paolo Beck-Peccoz
Paolo Beck-Peccoz
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Anna Spada
Anna Spada
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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Giovanna Mantovani
Giovanna Mantovani
Endocrinology and Diabetology Unit, Diabetology and Metabolic Disease Unit, Endocrinology Unit, Unit of Human Pathology, Surgical Department, Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad.Granelli, Via F. Sforza, 35, 20122 Milan, Italy
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suggested (8) , evidence indicates that the activation of CREB is mainly modulated by cAMP-dependent protein kinase A (PKA) (9) . PKA is a tetrameric enzyme composed of two catalytic and two regulatory subunits. There are four regulatory subunits (R1A, R1B
Leqi He
Leqi He
Department of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Xiaoying Li
Xiaoying Li
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Zaoping Chen
Zaoping Chen
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Wei Wang
Wei Wang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Kai Wang
Kai Wang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Xinmei Huang
Xinmei Huang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Qian Yang
Qian Yang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Wencai Ke
Wencai Ke
Department of Clinical Laboratory Medicine, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Jun Liu
Jun Liu
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Bingbing Zha
Bingbing Zha
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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protein kinase A (p-PKA) and phosphorylated versions of cAMP response element-binding protein (p-CREB) were purchased from Cell Signaling Technology. The antibodies against NIS were purchased from Proteintech (Chicago, IL, USA). Reverse transcription
Yufen Zhao
Yufen Zhao
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Erge Namei
Erge Namei
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Bingxue Yang
Bingxue Yang
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Xiangnan Bao
Xiangnan Bao
Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, PR China
National Center of Technology Innovation for Dairy Industry, Hohhot, PR China
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National Center of Technology Innovation for Dairy Industry, Hohhot, PR China
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Wei Sun
Wei Sun
Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, PR China
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Gerile Subudeng
Gerile Subudeng
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Guifang Cao
Guifang Cao
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Haijun Li
Haijun Li
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, PR China
Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Key Laboratory of Animal Embryo and Development Engineering of Autonomous Region Universities, Inner Mongolia Agricultural University, Hohhot, PR China
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Gui Wang
Gui Wang
Animal Genetic Breeding and Reproduction Research Center, Hetao College, Bayannur, PR China
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crucial intracellular second messenger that interacts with the regulatory subunits of cAMP-dependent protein kinase (PKA), leading to the activation of PKA activity. Subsequently, it regulates downstream target gene transcription or protein phosphorylation
Yao Ye
Yao Ye
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Aurelia Vattai
Aurelia Vattai
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Nina Ditsch
Nina Ditsch
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Christina Kuhn
Christina Kuhn
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Martina Rahmeh
Martina Rahmeh
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Sven Mahner
Sven Mahner
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Myriam Ripphahn
Myriam Ripphahn
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Roland Immler
Roland Immler
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Markus Sperandio
Markus Sperandio
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Udo Jeschke
Udo Jeschke
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Viktoria von Schönfeldt
Viktoria von Schönfeldt
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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cAMP/PKA signaling inhibits the secretion of progesterone via PKA ( 50 ) and the transcription of beta-hCG via CREB ( 49 ). The activated EP3/G i1 can stimulate p-ERK1/2 and p53, which eventually enhance PAI-1 gene transcription ( 52 ). These changes
Irasema Mendieta
Irasema Mendieta
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico
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Rosa Elvira Nuñez-Anita
Rosa Elvira Nuñez-Anita
Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás Hidalgo, Morelia, Michoacán, Mexico
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Gilberto Pérez-Sánchez
Gilberto Pérez-Sánchez
Departmento de Psicoimunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
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Lenin Pavón
Lenin Pavón
Departmento de Psicoimunología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
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Alfredo Rodríguez-Cruz
Alfredo Rodríguez-Cruz
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico
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Guadalupe García-Alcocer
Guadalupe García-Alcocer
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico
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Laura Cristina Berumen
Laura Cristina Berumen
Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Mexico
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of neuroendocrine characteristics via two main mechanisms ( Fig. 10 ), namely a classical pathway that involves the release of the catalytic subunits of PKA and an alternative pathway that promotes the activation of the EPAC pathway ( 13 , 14 , 26
Tatiana V Novoselova
Tatiana V Novoselova
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Peter J King
Peter J King
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Leonardo Guasti
Leonardo Guasti
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Louise A Metherell
Louise A Metherell
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Adrian J L Clark
Adrian J L Clark
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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Li F Chan
Li F Chan
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK
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histopathology showing the absence of fasciculata or reticularis cells together with disorganisation of zona granulosa (ZG) cells ( 16 ). Recent data in mouse models show that PKA signalling overactivation drives the differentiation of a reticularis-like zone in
Carolina Inda
Carolina Inda
Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina
DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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Natalia G Armando
Natalia G Armando
Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Paula A dos Santos Claro
Paula A dos Santos Claro
Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina
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Susana Silberstein
Susana Silberstein
Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina
DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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been implicated in CRHR functions, including ERK1/2 and p38 MAPKs, PKA, Akt, NFkB, GSK-3b/Wnt, RhoA as well as other important signaling molecules such as cAMP, calcium, IP3 and nitric oxide/cGMP ( 10 ). Here, we review the principal characteristics
Yusaku Mori
Yusaku Mori
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Hiroyuki Shimizu
Hiroyuki Shimizu
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
Maebashi Hirosegawa Clinic, Maebashi, Gunma, Japan
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Maebashi Hirosegawa Clinic, Maebashi, Gunma, Japan
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Hideki Kushima
Hideki Kushima
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Tomomi Saito
Tomomi Saito
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Munenori Hiromura
Munenori Hiromura
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Michishige Terasaki
Michishige Terasaki
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Masakazu Koshibu
Masakazu Koshibu
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Hirokazu Ohtaki
Hirokazu Ohtaki
Department of Anatomy, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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Tsutomu Hirano
Tsutomu Hirano
Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
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-dependent protein kinase (PKA) ( 38 ). PKA has been shown to directly activate LKB1 ( 39 ); hence, PKA may potentially play a role upstream of the LKB1/AMPK pathway in nesfatin-1 receptor signaling in VECs (the proposed signaling pathway is presented in
Katrine M Lauritsen
Katrine M Lauritsen
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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Jens Hohwü Voigt
Jens Hohwü Voigt
Steno Diabetes Center Aarhus, Aarhus, Denmark
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Steen Bønløkke Pedersen
Steen Bønløkke Pedersen
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Troels K Hansen
Troels K Hansen
Steno Diabetes Center Aarhus, Aarhus, Denmark
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Niels Møller
Niels Møller
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
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Niels Jessen
Niels Jessen
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Biomedicine, Aarhus University, Aarhus, Denmark
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Department of Biomedicine, Aarhus University, Aarhus, Denmark
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Lars C Gormsen
Lars C Gormsen
Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark
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Esben Søndergaard
Esben Søndergaard
Steno Diabetes Center Aarhus, Aarhus, Denmark
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
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TGX Stain-Free Precast Gels (Bio-Rad). Levels of GLUT4, phosphorylation of HSL and PKA phosphorylation of PLIN1 were analyzed. Phosphorylation of HSL is expressed as a ratio of total HSL level. The total protein load that was confirmed by statistical
Giovanni Tulipano
Giovanni Tulipano
Unit of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
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has been shown to affect the signalling pathway mediated by the cAMP-dependent protein kinase (PKA) activation and cAMP-responsive element-binding protein (CREB) phosphorylation in different cell types ( 12 , 27 ). In hepatocytes, biguanides suppress
