Sarmistha Banerjee
Sarmistha Banerjee
Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Allison M Hayes
Allison M Hayes
Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Bernard H Shapiro
Bernard H Shapiro
Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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. Endocrinology 1999 140 1245 – 1254 . ( https://doi.org/10.1210/endo.140.3.6545 ) 13 Thangavel C Garcia MC Shapiro BH . Intrinsic sex differences determine expression of growth hormone-regulated female cytochrome P450s . Molecular and Cellular
Lasse Oinonen
Lasse Oinonen
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
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Antti Tikkakoski
Antti Tikkakoski
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Jenni Koskela
Jenni Koskela
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Arttu Eräranta
Arttu Eräranta
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
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Mika Kähönen
Mika Kähönen
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
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Onni Niemelä
Onni Niemelä
Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital, Seinäjoki, Finland
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Jukka Mustonen
Jukka Mustonen
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Ilkka Pörsti
Ilkka Pörsti
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
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(r P ) and Spearman’s (r S ) correlations were calculated, as appropriate. Multivariable linear regression analyses with backward elimination were used to investigate the explanatory factors for the haemodynamic variables. The selection criterium
Laura Hasse
Laura Hasse
Department of Pediatric Dermatology and Allergology, Children’s Hospital Auf der Bult, Hannover, Germany
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Dagmar Jamiolkowski
Dagmar Jamiolkowski
Department of Pediatric Dermatology and Allergology, Children’s Hospital Auf der Bult, Hannover, Germany
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Felix Reschke
Felix Reschke
Department of Pediatric Diabetology, Children’s Hospital Auf der Bult, Hannover, Germany
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Kerstin Kapitzke
Kerstin Kapitzke
Department of Pediatric Diabetology, Children’s Hospital Auf der Bult, Hannover, Germany
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Jantje Weiskorn
Jantje Weiskorn
Department of Pediatric Diabetology, Children’s Hospital Auf der Bult, Hannover, Germany
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Olga Kordonouri
Olga Kordonouri
Department of Pediatric Diabetology, Children’s Hospital Auf der Bult, Hannover, Germany
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Torben Biester
Torben Biester
Department of Pediatric Diabetology, Children’s Hospital Auf der Bult, Hannover, Germany
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Hagen Ott
Hagen Ott
Department of Pediatric Dermatology and Allergology, Children’s Hospital Auf der Bult, Hannover, Germany
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parameters on skin changes, Pearson’s correlation test and linear regression were applied. P < 0.05 was considered statistically significant. Results Study population A total of 134 patients were screened from January to December 2021, of whom
Ingeborg Brønstad
Ingeborg Brønstad
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Lars Breivik
Lars Breivik
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Paal Methlie
Paal Methlie
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Anette S B Wolff
Anette S B Wolff
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Eirik Bratland
Eirik Bratland
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Ingrid Nermoen
Ingrid Nermoen
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Kristian Løvås
Kristian Løvås
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Eystein S Husebye
Eystein S Husebye
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, Division of Medicine, University of Bergen, 5021 Bergen, Norway
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of P450c21 is required for membrane insertion and enzyme stability . Journal of Biological Chemistry 1993 268 14682 – 14686 . 30 Lajic S Nikoshkov A Holst M Wedell A . Effects of missense mutations and deletions on membrane anchoring
Mengting Yin
Mengting Yin
Sichuan University West China Hospital, Chengdu, China
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Qianhui Liu
Qianhui Liu
Sichuan University West China Hospital, Chengdu, China
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Qingzhong Wang
Qingzhong Wang
Jintang First People’s Hospital, West China Hospital Sichuan University Jingtang Hospital, Chengdu, China
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Yong He
Yong He
Sichuan University West China Hospital, Chengdu, China
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Haolan Song
Haolan Song
Sichuan University West China Hospital, Chengdu, China
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Xin Nie
Xin Nie
Sichuan University West China Hospital, Chengdu, China
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Guixing Li
Guixing Li
Sichuan University West China Hospital, Chengdu, China
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, parathyroid hormone. The diagnostic power for the Ca/P ratio We analyzed the diagnostic performance of the Ca/P ratio using ROCs. The cut-off point was calculated using Youden’s index (sensitivity + specificity − 1). The ROC curve showed that
Devis Pascut
Devis Pascut
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Sofia Tamini
Sofia Tamini
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
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Silvia Bresolin
Silvia Bresolin
Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
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Pablo Giraudi
Pablo Giraudi
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Giuseppe Basso
Giuseppe Basso
Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
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Alessandro Minocci
Alessandro Minocci
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Claudio Tiribelli
Claudio Tiribelli
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Graziano Grugni
Graziano Grugni
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Alessandro Sartorio
Alessandro Sartorio
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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threshold at P < 0.05. The enrichment analysis was performed using the Fisher’s exact test with a Hypergeometric distribution corrected for multiple testing by using the false discovery rate (FDR) correction. Data analysis and statistical methods
Qiuli Liu
Qiuli Liu
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Lin-ang Wang
Lin-ang Wang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Jian Su
Jian Su
Department of Urology, Affiliated Hospital of Nanjing University of Traditional Chinese Medical, Nanjing, People’s Republic of China
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Dali Tong
Dali Tong
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Weihua Lan
Weihua Lan
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Luofu Wang
Luofu Wang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Gaolei Liu
Gaolei Liu
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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Jun Zhang
Jun Zhang
Department of Obstetrics, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China
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Victor Wei Zhang
Victor Wei Zhang
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
AmCare Genomics Lab, Guangzhou, People’s Republic of China
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AmCare Genomics Lab, Guangzhou, People’s Republic of China
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Dianzheng Zhang
Dianzheng Zhang
Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA
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Rongrong Chen
Rongrong Chen
Geneplus-Beijing Institute, Beijing, People’s Republic of China
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Qingyi Zhu
Qingyi Zhu
Department of Urology, Affiliated Hospital of Nanjing University of Traditional Chinese Medical, Nanjing, People’s Republic of China
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Jun Jiang
Jun Jiang
Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China
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. Six cytochrome P450 (CYP) enzymes including CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1 and CYP21A2 are involved in the synthesis of steroid hormones. Although deficiencies of any of these enzymes can result in CAH ( 3 ), CYP21A2 deficiency (21OHD
Piera Rizzolo
Piera Rizzolo
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Valentina Silvestri
Valentina Silvestri
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Virginia Valentini
Virginia Valentini
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Veronica Zelli
Veronica Zelli
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Agostino Bucalo
Agostino Bucalo
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Ines Zanna
Ines Zanna
Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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Simonetta Bianchi
Simonetta Bianchi
Division of Pathological Anatomy, Department of Sciences of Health, University of Florence, Florence, Italy
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Maria Grazia Tibiletti
Maria Grazia Tibiletti
Department of Pathology, ASST Settelaghi and Centro di Ricerca per lo Studio dei Tumori Eredo-Familiari, Università dell’Insubria, Varese, Italy
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Antonio Russo
Antonio Russo
Section of Medical Oncology, Department of Surgical and Oncological and Oral Sciences, University of Palermo, Palermo, Italy
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Liliana Varesco
Liliana Varesco
IRCCS Ospedale Policlinico San Martino, Genoa, Italy
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Gianluca Tedaldi
Gianluca Tedaldi
Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy
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Bernardo Bonanni
Bernardo Bonanni
Division of Cancer Prevention and Genetics IEO, European Institute of Oncology IRCCS, Milan, Italy
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Jacopo Azzollini
Jacopo Azzollini
Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
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Siranoush Manoukian
Siranoush Manoukian
Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy
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Anna Coppa
Anna Coppa
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
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Giuseppe Giannini
Giuseppe Giannini
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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Laura Cortesi
Laura Cortesi
Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy
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Alessandra Viel
Alessandra Viel
Unit of Functional Onco-Genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy
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Marco Montagna
Marco Montagna
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV – IRCCS, Padua, Italy
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Paolo Peterlongo
Paolo Peterlongo
Genome Diagnostics Program, IFOM – The FIRC Institute of Molecular Oncology, Milan, Italy
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Paolo Radice
Paolo Radice
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy
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Domenico Palli
Domenico Palli
Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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Laura Ottini
Laura Ottini
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
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etiology and treatment: effects on estrogen biosynthesis, metabolism, and response to endocrine therapy . Cancer Causes and Control 2015 319 – 332 . ( https://doi.org/10.1007/s10552-014-0519-7 ) 11 Go RE Hwang KA Choi KC . Cytochrome P450 1
Yuan Zhou
Yuan Zhou
Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
Laboratory of Endocrinology, Medical Research Center, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
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Laboratory of Endocrinology, Medical Research Center, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
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ShengNan Wang
ShengNan Wang
Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
Laboratory of Endocrinology, Medical Research Center, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
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Laboratory of Endocrinology, Medical Research Center, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
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Jing Wu
Jing Wu
Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
Laboratory of Endocrinology, Medical Research Center, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
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Laboratory of Endocrinology, Medical Research Center, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
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JianJun Dong
JianJun Dong
Department of Endocrinology, Qilu Hospital of Shandong University, Ji-nan, China
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Lin Liao
Lin Liao
Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University, Ji-nan, China
Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, China
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Department of Endocrinology and Metabology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Ji-nan, China
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.A450T 31 3 NA p.T82P 32 9 NA p.R377L 33 2 NA p.G44S 34 7 NA p.A259S 35 2 NA p.R43H 36 7 NA p.R250C 37 2 NA p.G44S 38 9 NA p.T354M 39 4 NA p.D135E
Taís S Assmann
Taís S Assmann
Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Mariana Recamonde-Mendoza
Mariana Recamonde-Mendoza
Institute of Informatics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Bianca M De Souza
Bianca M De Souza
Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Daisy Crispim
Daisy Crispim
Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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Postgraduation Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
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. ( 63 ) Mice Plasma Up Garcia-Contreras et al . ( 72 ) Human Plasma-derived exosome Down miR-424-5p Wang et al . 2017 ( 73 ) Human PBMCs Down Takahashi et al . ( 23 ) Human PBMCs Up miR-450a-2-3p
