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Irvin M Modlin Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Harry Aslanian Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Lisa Bodei Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA
Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Ignat Drozdov Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Mark Kidd Wren Laboratories, Yale University School of Medicine, 35 NE Industrial Road, Branford, Connecticut, USA

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Introduction The National Cancer Institute (NCI) Neuroendocrine Tumor (NET) Summit conference proceedings of 2008 identified that a critical unmet need in the management of NET disease was the absence of a sensitive and specific set of tumor

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0100
Volume/Issue:
Volume 3: Issue 4
Open access
Matteo Scopel Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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Eugenio De Carlo Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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Francesca Bergamo Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Sabina Murgioni Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Riccardo Carandina Radiodiagnostic Unit, University Hospital of Padua, Padua, Italy

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Anna Rita Cervino Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Marta Burei Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Federica Vianello Radiotherapy and Nuclear Medicine Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy

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Vittorina Zagonel Unit of Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy

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Matteo Fassan Surgical Pathology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy

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Roberto Vettor Medical Clinic III, Department of Medicine (DIMED), University Hospital of Padua, Padua, Italy

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prevalence due to the more favorable prognosis ( 3 ). In Europe, the number of patients affected by NET in 2016 was estimated to be 292,971 ( 4 ). The skeletal system is a common site of metastasis for many solid tumors, but bone involvement by NETs has

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0568
Volume/Issue:
Volume 11: Issue 7
Open access
Mark J C van Treijen Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands

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Catharina M Korse Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wieke H Verbeek Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Gastroenterology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Margot E T Tesselaar Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands
Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Gerlof D Valk Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
Center for Neuroendocrine Tumors, ENETS Center of Excellence, Netherlands Cancer Institute, University Medical Center Utrecht, Utrecht, The Netherlands

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-peptide PET/CT (DOTA-PET/CT), are used for risk stratification. Consequently, DOTA-PET/CT is currently one of the few diagnostics in NET disease with a strong impact on clinical management. Its diagnostic sensitivity is superior to anatomical imaging, leading

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0146
Volume/Issue:
Volume 11: Issue 10
Open access
Ashley K Clift Department of Surgery and Cancer, Imperial College London, London, UK

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Omar Faiz Department of Surgery, St Mark’s Hospital, London, UK

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Robert Goldin Centre for Pathology, Imperial College London, London, UK

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John Martin Department of Gastroenterology, Imperial College London, London, UK

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Harpreet Wasan Department of Surgery and Cancer, Imperial College London, London, UK

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Marc-Olaf Liedke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Erik Schloericke Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany

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Anna Malczewska Department of Surgery and Cancer, Imperial College London, London, UK
Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland

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Guido Rindi Institute of Anatomic Pathology, Universita Cattolica del Sacro Cuore, Rome, Italy

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Mark Kidd Wren Laboratories, Branford, Connecticut, USA

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Irvin M Modlin Emeritus Professor Gastrointestinal Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA

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Andrea Frilling Department of Surgery and Cancer, Imperial College London, London, UK

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Introduction Small bowel (SB) neuroendocrine tumours (NET) are accruing significant clinical attention due to their increasing incidence ( 1 , 2 ) in addition to recent advances in their molecular biology ( 3 , 4 , 5 , 6 ) and treatment

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0114
Volume/Issue:
Volume 6: Issue 2
Open access
R C S van Adrichem
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L J Hofland
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R A Feelders
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M C De Martino
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P M van Koetsveld
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C H J van Eijck Department of Internal Medicine, Department of Surgery, Department of Pathology, Sector of Endocrinology, Erasmus MC, ‘s Gravendijkwal 230, Room D-430, 3015 CE Rotterdam, The Netherlands

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R R de Krijger Department of Internal Medicine, Department of Surgery, Department of Pathology, Sector of Endocrinology, Erasmus MC, ‘s Gravendijkwal 230, Room D-430, 3015 CE Rotterdam, The Netherlands

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D M Sprij-Mooij
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J A M J L Janssen
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W W de Herder
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considered as important biochemical and pathological markers, respectively, for GEP NET clinical behaviour. The insulin-like growth factor (IGF) system has been suggested as an important regulator of GEP NET proliferation and differentiation (2) . Up to

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-13-0052
Volume/Issue:
Volume 2: Issue 4
Open access
Roxanne C S van Adrichem Department of Internal Medicine, Sector of Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumors, Erasmus MC, Rotterdam, The Netherlands

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Aart Jan van der Lely Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Martin Huisman Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Piet Kramer Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Richard A Feelders Department of Internal Medicine, Sector of Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumors, Erasmus MC, Rotterdam, The Netherlands

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Patric J D Delhanty Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Wouter W de Herder Department of Internal Medicine, Sector of Endocrinology, ENETS Centre of Excellence for Neuroendocrine Tumors, Erasmus MC, Rotterdam, The Netherlands

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function of ghrelin in NETs is not well understood. It has been suggested that ghrelin could be responsible for the striking maintenance of body mass index (BMI) that can be observed in NET patients ( 15 , 28 ). Although total serum ghrelin levels in NET

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0021
Volume/Issue:
Volume 5: Issue 4
Open access
Hyunjae Lee Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea

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Tae-Shin Kim Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Republic of Korea

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Ja-Yoon Gu Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

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Mi Ran Yu Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea

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Seung-Eun Lee Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea

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Eun Sook Kim Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea

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Hyun Kyung Kim Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea

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extracellular trap (NET) ( 11 ). NET has been linked with pathogenesis of cancer, including proliferation of cancer cells, angiogenesis, awakening dormant cancer cells, and metastasis ( 12 , 13 ). Therefore, studies addressing the significant association of NET

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0400
Volume/Issue:
Volume 12: Issue 12
Open access
Elham Barazeghi Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Rudbeck Laboratory, Uppsala, Sweden

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Per Hellman Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Rudbeck Laboratory, Uppsala, Sweden

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Gunnar Westin Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Rudbeck Laboratory, Uppsala, Sweden

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Peter Stålberg Department of Surgical Sciences, Uppsala University, Uppsala University Hospital, Rudbeck Laboratory, Uppsala, Sweden

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give rise to carcinoid syndrome as a major cause of morbidity and mortality in approximately 20% of SI-NET patients. To date, genetic and epigenetic alterations in SI-NETs are poorly studied. Massive DNA sequencing analysis on SI-NETs revealed that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0279
Volume/Issue:
Volume 8: Issue 8
Open access
Katherine Van Loon
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Li Zhang
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Jennifer Keiser
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Cendy Carrasco
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Katherine Glass The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA

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Maria-Teresa Ramirez The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA

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Sarah Bobiak The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA

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Eric K Nakakura
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Alan P Venook
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Manisha H Shah The UCSF Helen Diller Family Comprehensive Cancer Center, The Ohio State University Comprehensive Cancer Center, National Comprehensive Cancer Network, University of California, San Francisco, 1600 Divisadero Street, UCSF Box 1770, San Francisco, California 94143, USA

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Emily K Bergsland
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with the National Comprehensive Cancer Network (NCCN) Oncology Outcomes Database, we identified all patients 18 years of age or older who presented to either UCSF or OSUMC for care of a NET on or after January 1, 2004 and before December 31, 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0119
Volume/Issue:
Volume 4: Issue 1
Open access
Carole Morin Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Keo-Morakort Benedetto Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Agathe Deville Hospices Civils de Lyon, Hôpital Louis Pradel, Médecine Nucléaire, Bron, France
Centre de Recherche en Cancérologie de Lyon, UMR Inserm 1052 CNRS 5286, Lyon Cedex 08, France

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Laurent Milot Hospices Civils de Lyon, Hôpital Edouard Herriot, Radiologie, Lyon Cedex 03, France
University of Lyon, Université Lyon 1, France

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Aurélie Theillaumas Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Valérie Hervieu Centre de Recherche en Cancérologie de Lyon, UMR Inserm 1052 CNRS 5286, Lyon Cedex 08, France
University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Institut de Pathologie Est, Bron Cedex, France

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Mathieu Pioche University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Hôpital Edouard Herriot, Gastroentérologie, Lyon Cedex 03, France

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Gilles Poncet Centre de Recherche en Cancérologie de Lyon, UMR Inserm 1052 CNRS 5286, Lyon Cedex 08, France
University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Hôpital Edouard Herriot, Chirurgie Digestive, Lyon Cedex 03, France

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Julien Forestier Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Laurent François Hospices Civils de Lyon, Hôpital Louis Pradel, Exploration Fonctionnelle, Bron Cedex, France

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Francoise Borson-Chazot University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Hôpital Louis Pradel, Endocrinologie, Bron Cedex, France

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Mustapha Adham University of Lyon, Université Lyon 1, France
Hospices Civils de Lyon, Hôpital Edouard Herriot, Chirurgie Digestive, Lyon Cedex 03, France

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Catherine Lombard-Bohas Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France

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Thomas Walter Hospices Civils de Lyon, Hôpital Edouard Herriot, Oncologie Digestive, Lyon Cedex 03, France
Centre de Recherche en Cancérologie de Lyon, UMR Inserm 1052 CNRS 5286, Lyon Cedex 08, France
University of Lyon, Université Lyon 1, France

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initial characterizations and their management are varied and complex. Therefore, national ( 3 ) and international ( 4 , 5 , 6 ) guidelines were regularly updated to help physicians to optimize NEN management, both for neuroendocrine tumours (NET) and

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-22-0097
Volume/Issue:
Volume 11: Issue 6
Open access