Lei Lei
Lei Lei
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Yi-Hua Bai
Yi-Hua Bai
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Hong-Ying Jiang
Hong-Ying Jiang
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Ting He
Ting He
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Meng Li
Meng Li
Department of Nephrology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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Jia-Ping Wang
Jia-Ping Wang
Department of Radiology, The Second Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China
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-cells ( 8 ). Nevertheless, the exact role of m6A methylation in T2D has not been explored. In this study, bioinformatics is used to investigate the biological role and underlying mechanism of m6A methylation genes in T2D, and the INS gene was screened
Ivar Følling
Ivar Følling
Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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Anna B Wennerstrøm
Anna B Wennerstrøm
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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Tor J Eide
Tor J Eide
Division of Laboratory Medicine, Department of Pathology, Oslo University Hospital, Oslo, Norway
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Hilde Loge Nilsen
Hilde Loge Nilsen
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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transcripts composed of exons from both genes: the INS-IGF2 transcript 1, a long transcript believed never to be translated into protein as an early stop codon targets it to nonsense-mediated decay, and INS-IGF2 transcript 2, a shorter transcript ( Fig. 1
Annette Mouritsen
Annette Mouritsen
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Alexander Siegfried Busch
Alexander Siegfried Busch
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Lise Aksglaede
Lise Aksglaede
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Ewa Rajpert-De Meyts
Ewa Rajpert-De Meyts
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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+ (pubarche) and TV (testicular volume) >3 mL stratified by UGT2B17 genotype. UGT2B17 genotype del/del ( n = 59) del/ins ( n = 309) ins/ins ( n = 300) P value Median age in yrs (25th and 75th percentile) 11.38 (8
K L Gatford
K L Gatford
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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G K Heinemann
G K Heinemann
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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S D Thompson
S D Thompson
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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J V Zhang
J V Zhang
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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S Buckberry
S Buckberry
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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J A Owens
J A Owens
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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G A Dekker
G A Dekker
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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C T Roberts
C T Roberts
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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on behalf of the SCOPE Consortium
on behalf of the SCOPE Consortium
School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia
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genes for H19 , IGF2 , insulin ( INS ), tyrosine hydroxylase ( TH ) and an antisense IGF2 gene overlapping with IGF2 ( IGF2-AS ). The H19 long non-coding RNA in this cluster is maternally expressed and this imprinting appears to remain stable
Aneta Gawlik
Aneta Gawlik
Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Michael Shmoish
Michael Shmoish
Bioinformatics Knowledge Unit, Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion – Israel Institute of Technology, Haifa, Israel
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Michaela F Hartmann
Michaela F Hartmann
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Stefan A Wudy
Stefan A Wudy
Steroid Research & Mass Spectrometry Unit, Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany
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Zbigniew Olczak
Zbigniew Olczak
Department of Diagnostic Imaging, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Katarzyna Gruszczynska
Katarzyna Gruszczynska
Department of Diagnostic Imaging, School of Medicine in Katowice, Medical University of Silesia, Upper Silesia Children’s Care Health Centre, Katowice, Poland
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Ze’ev Hochberg
Ze’ev Hochberg
Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
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previously described ( 11 ). Morning fasting venous blood samples were collected to measure lipids, glucose (GLU), insulin (INS), TSH, fT4, cortisol and aminotransferases. Plasma total cholesterol (T Chol), high-density lipoprotein cholesterol (HDL-Chol) and
Ping Gu
Ping Gu
Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Yuege Lin
Yuege Lin
Department of Pathology, Nanjing Medical University, Nanjing, China
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Qi Wan
Qi Wan
Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Dongming Su
Dongming Su
Department of Pathology, Nanjing Medical University, Nanjing, China
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Qun Shu
Qun Shu
Department of Obstetrics, Shanghai First Maternity and Infant Health Hospital, School of Medicine, Tongji University, Shanghai, China
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viability, EdU assays, and glucose-stimulated insulin secretion (GSIS) in vitro Rat insulinoma INS1 cells were cultured in RPMI-1640 medium with 10% fetal bovine serum and 50 μM β-mercaptoethanol at 37°C (5% CO 2 , 95% air). After incubation with
Shan Wu
Shan Wu
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, People’s Republic of China
Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Jianjun Zhou
Jianjun Zhou
Research Center for Translational Medicine, Cancer Stem Cell Institute, East Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China
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Jing Guo
Jing Guo
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of China
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Zhan Hua
Zhan Hua
Department of General Surgery, China-Japan Friendship Hospital, Beijing, People’s Republic of China
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Jianchen Li
Jianchen Li
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, People’s Republic of China
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Zai Wang
Zai Wang
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of China
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metastasis models using two typical types of PNET cells: insulinoma cells, represented by INS-1 (a type of functional PNET), and INR1G9 cells, which are non-functional PNET cells. We found that the PNET inhibition effect of apatinib was generally comparable
Bo Zhu
Bo Zhu
Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Yumei Chen
Yumei Chen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Fang Xu
Fang Xu
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Xiaolu Shen
Xiaolu Shen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Xuanyu Chen
Xuanyu Chen
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China
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Jieqiang Lv
Jieqiang Lv
Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
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Songying Zhang
Songying Zhang
Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
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in islets of the well-established dehydroepiandrosterone (DHEA)-induced PCOS animal model and revealed the effects of testosterone (TE) on ER stress and apoptosis in both INS-1 cells and primary cultured mouse islets. Finally, we demonstrated that TE
Tao Yuan
Tao Yuan
Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Lanping Jiang
Lanping Jiang
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Chen Chen
Chen Chen
Department of Pediatrics, State Key Laboratory of Medical Genetics, Xiangya Hospital, Central South University, Changsha, China
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Xiaoyan Peng
Xiaoyan Peng
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Min Nie
Min Nie
Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Xuemei Li
Xuemei Li
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Xiaoping Xing
Xiaoping Xing
Department of Endocrinology & Key Laboratory of Endocrinology, The National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Xuewang Li
Xuewang Li
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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Limeng Chen
Limeng Chen
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
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of Matsuda and DeFronzo for insulin sensitivity is defined by the following formula: 10,000/square root (Gluc 0 × Ins 0 × mean Gluc × mean Ins). The mean glucose and the mean insulin levels were calculated using measurements obtained at baseline and
Xinyuan Zhang
Xinyuan Zhang
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China
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School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China
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Suiyan Li
Suiyan Li
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, China
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Hongwei Liu
Hongwei Liu
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Huai Bai
Huai Bai
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Qingqing Liu
Qingqing Liu
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Chunyi Yang
Chunyi Yang
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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Ping Fan
Ping Fan
Laboratory of Genetic Disease and Perinatal Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China
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-C), LDL-cholesterol (LDL-C), total cholesterol (TC), triglycerides (TG), apolipoprotein (apo) A1, and apoB levels, plasma Glu and insulin (Ins) concentrations, and the homeostatic model assessment of insulin resistance (HOMA-IR) were determined or
