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A J Varewijck Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands

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A J van der Lely Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands

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S J C M M Neggers Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands

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S W J Lamberts Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands

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L J Hofland Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands

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J A M J L Janssen Erasmus MC, Department of Internal Medicine, Division of Endocrinology, 's-Gravendijkwal 230, Room D-443, 3015 CE Rotterdam, The Netherlands

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are still used to assess IGF1 bioactivity has been the lack of reliable assays to measure IGF1 bioactivity. An IGF1 receptor (IGF1R)-specific kinase receptor activation (KIRA) assay has been developed as an alternative method to evaluate circulating

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0028
Volume/Issue:
Volume 3: Issue 2
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R C S van Adrichem
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L J Hofland
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R A Feelders
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M C De Martino
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P M van Koetsveld
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C H J van Eijck Department of Internal Medicine, Department of Surgery, Department of Pathology, Sector of Endocrinology, Erasmus MC, ‘s Gravendijkwal 230, Room D-430, 3015 CE Rotterdam, The Netherlands

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R R de Krijger Department of Internal Medicine, Department of Surgery, Department of Pathology, Sector of Endocrinology, Erasmus MC, ‘s Gravendijkwal 230, Room D-430, 3015 CE Rotterdam, The Netherlands

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D M Sprij-Mooij
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J A M J L Janssen
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W W de Herder
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functions in normal tissues and tumors, plays an important role in the pathophysiology of GEP NETs (2) . The IGF system consists of different IGF-related genes: two ligands (IGF1 and IGF2), two IGF receptors (IGF1R and IGF2R), two insulin receptors (IR

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-13-0052
Volume/Issue:
Volume 2: Issue 4
Open access
Doron Weinstein
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Rive Sarfstein
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Zvi Laron Department of Human Molecular Genetics and Biochemistry, Endocrinology and Diabetes Research Unit, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

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Haim Werner
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by ∼165% in the WT-AR-expressing PC3 cells ( Fig. 2 C). DHT treatment had no effect in the control, pcDNA3-transfected cells ( Fig. 2 B and C). Activation of INSR and IGF1R by insulin and IGF1: time dependency studies To identify the specific receptor(s

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Research Article
DOI:
https://doi.org/10.1530/EC-13-0086
Volume/Issue:
Volume 3: Issue 1
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Rossella Cannarella Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Teresa Mattina Genetics, University of Catania, Catania, Italy

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Rosita A Condorelli Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Laura M Mongioì Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Giuseppe Pandini Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Sandro La Vignera Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Aldo E Calogero Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Introduction Insulin-like growth factor 1 receptor ( IGF1R ) gene, made up of 315,991 base pairs, maps on the 15q26.3 chromosome. It encodes for a protein with a tyrosine kinase domain, which binds the IGF1 and is responsible for its

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0158
Volume/Issue:
Volume 6: Issue 7
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Yusaku Mori Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Shinagawa, Tokyo, Japan

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Eunhyoung Ko Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Rudolf Furrer Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Linda C Qu Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Stuart C Wiber Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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I George Fantus Departments of Medicine and Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Division of Endocrinology and Metabolism, Leadership Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada

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Mario Thevis Center for Preventive Doping Research and Institute of Biochemistry, German Sport University Cologne, Cologne, Germany

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Alan Medline Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
Department of Pathology, Humber River Regional Hospital, Toronto, Ontario, Canada

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Adria Giacca Departments of Physiology and Medicine, Institute of Medical Science, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada

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-term insulin therapy in type 2 diabetic patients and comparison of effects of insulin glargine, its metabolites, IGF-I, and human insulin on insulin and IGF-I receptor signaling . Diabetes 2013 62 2539 – 2544 . ( https://doi.org/10.2337/db12-1773 ) 10

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0358
Volume/Issue:
Volume 7: Issue 5
Open access
Adrian F Daly Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Liliya Rostomyan Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Daniela Betea Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Jean-François Bonneville Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Chiara Villa Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium
Department of Pathological Cytology and Anatomy, Foch Hospital, Paris, France

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Natalia S Pellegata Institute for Diabetes and Cancer, Helmholtz Zentrum München, Neuherberg, Germany

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Beatrice Waser Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Jean-Claude Reubi Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland

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Catherine Waeber Stephan Clinique Générale Ste-Anne, Fribourg, Switzerland

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Emanuel Christ Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland

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Albert Beckers Department of Endocrinology, Centre Hospitalier Universitaire (CHU) de Liège, Liège Université, Domaine Universitaire du Sart-Tilman, Liège, Belgium

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Introduction Acromegaly is a rare, classical endocrine disorder that is due to chronic excess secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) that has a prevalence of 1 in 8000–14,000 of the population ( 1 , 2 , 3

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0004
Volume/Issue:
Volume 8: Issue 4
Open access
Kennett Sprogøe Ascendis Pharma A/S, Hellerup, Denmark

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Eva Mortensen Ascendis Pharma, Inc., Palo Alto, California, USA

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David B Karpf Ascendis Pharma, Inc., Palo Alto, California, USA

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Jonathan A Leff Ascendis Pharma, Inc., Palo Alto, California, USA

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critical for a wide variety of bodily functions, including adiposity regulation, glucose control, lipid metabolism, and cognition ( 1 , 2 , 3 ). These effects are mediated both directly by GH and indirectly by insulin-like growth factor (IGF-1). In target

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0203
Volume/Issue:
Volume 6: Issue 8
Open access
Wenjun Long Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Tuo Zhou Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Xiuping Xuan Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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Qiuli Cao Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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Zuojie Luo Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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Yingfen Qin Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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Qin Ning Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Xiaoping Luo Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Xuemei Xie Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans . Cell Metabolism 2013 17 197 – 209 . ( https://doi.org/10.1016/j.cmet.2013.01.009 ) 24 Singh R Smith E Fathzadeh M Liu W Go

Article Type:
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Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-21-0203
Volume/Issue:
Volume 11: Issue 1
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Rachel D C A Diniz
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Renata M Souza
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Roberto Salvatori Division of Endocrinology, Division of Endocrinology, Division of Hepatology, Division of Radiology, Diabetes and Metabolism, Federal University of Sergipe, Aracaju, Brazil

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Alex Franca Division of Endocrinology, Division of Endocrinology, Division of Hepatology, Division of Radiology, Diabetes and Metabolism, Federal University of Sergipe, Aracaju, Brazil

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Elenilde Gomes-Santos
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Thiago O Ferrão Division of Endocrinology, Division of Endocrinology, Division of Hepatology, Division of Radiology, Diabetes and Metabolism, Federal University of Sergipe, Aracaju, Brazil

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Carla R P Oliveira
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João A M Santana
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Francisco A Pereira
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Rita A A Barbosa
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Anita H O Souza
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Rossana M C Pereira
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Alécia A Oliveira-Santos
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Allysson M P Silva
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Francisco J Santana-Júnior
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Eugênia H O Valença
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Viviane C Campos
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Manuel H Aguiar-Oliveira
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the GHRH receptor gene ( GHRHR ) (15) . These subjects have very low circulating serum IGF1 levels and could therefore be predisposed to developing NAFLD (16) . Despite abdominal obesity and unfavorable cardiovascular risk profile (high total and LDL

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-14-0078
Volume/Issue:
Volume 3: Issue 3
Open access
Peter Wolf Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

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Alexandre Dormoy Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Luigi Maione Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Sylvie Salenave Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Jacques Young Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Peter Kamenický Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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Philippe Chanson Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Service d’Endocrinologie et des Maladies de la Reproduction, Centre de Référence des Maladies Rares de l’Hypophyse, Le Kremlin-Bicêtre, France

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multireceptor ligand of somatostatin receptor (SSTR) subtypes 1, 2, 3 and 5 ( 11 ). It is recommended as second-line therapy for patients with acromegaly uncontrolled by surgery or first-generation SRLs in the presence of a clinically relevant residual tumor ( 1

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0296
Volume/Issue:
Volume 11: Issue 12
Open access