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R Perchard, L Magee, A Whatmore, F Ivison, P Murray, A Stevens, M Z Mughal, S Ehtisham, J Campbell, S Ainsworth, M Marshall, M Bone, I Doughty and P E Clayton

and Care Excellence (NICE) HbA1c target of <6.5%. The incidence of vitamin D deficiency, as reliably defined by serum 25-hydroxyvitamin D [25(OH)D] <50 nmol/L ( 3 , 4 , 5 , 6 ), has been estimated at 8–24% in UK children ( 7 ), with particularly

Open access

Louise Færch, Anders Juul, Ulrik Pedersen-Bjergaard and Birger Thorsteinsson

of exposure to recurrent hypoglycemia. If the latter is the case, a positive association between IGF1 levels and HbA1c would be expected. Previous studies have supported the existence of a negative association between IGF1 levels and HbA1c (6, 7, 8

Open access

Daiki Kobayashi, Nagato Kuriyama, Keita Hirano, Osamu Takahashi and Hiroshi Noto

that diabetic patients who had higher hemoglobin A1c (HbA1c) levels had higher incidence rates of malignancies compared to those who had lower HbA1c levels ( 19 , 20 , 21 , 22 ). In addition to the controversy regarding the association of glycemic

Open access

Dmitry M Davydov and Malik K Nurbekov

hemoglobin that is bound by glucose (HbA 1c ) reflects an average level of plasma glucose over the previous 2–4 months and is also widely used as a marker of chronic glycemia. It was concluded that HbA 1c and FPG display a different sensitivity versus

Open access

Xiao-jun Zhou, Lin Ding, Jia-xin Liu, Le-qun Su, Jian-jun Dong and Lin Liao

, and others received placebo). Study population Patients were recruited from 16 hospitals in Shandong Province, China. Eligible patients were male or female, 18–78 years of age and had type 2 diabetes with hemoglobin A1c (HbA1c) values ranging

Open access

Xiang Hu, Qiao Zhang, Tian-Shu Zeng, Jiao-Yue Zhang, Jie Min, Sheng-Hua Tian, Hantao Huang, Miaomiao Peng, Nan Zhang, Mengjiao Li, Qing Wan, Fei Xiao, Yan Chen, Chaodong Wu and Lu-Lu Chen

recommends that it is reasonable to consider an A1c range of 5.7–6.4% as identifying individuals with prediabetes ( 8 ), while HbA1c is not considered to be a suitable diagnostic test for prediabetes by WHO and many other diabetes societies ( 9 , 10

Open access

Jothydev Kesavadev, Pradeep Babu Sadasivan Pillai, Arun Shankar, Gopika Krishnan and Sunitha Jothydev

shown to reduce HbA1c and delay the need for insulin therapy ( 5 ). Sitagliptin as add-on therapy in T2DM has reported to provide persistent beneficial effects on short-term, intermediate-term and long-term biomarkers of metabolic control, as well as on

Open access

Helga Schultz, Svend Aage Engelholm, Eva Harder, Ulrik Pedersen-Bjergaard and Peter Lommer Kristensen

for analysis of HbA1c, C-peptide, lipids and plasma glucose. HbA1c was measured using a commercial liquid chromatography analysis, normal range <48 mmol/mol. Other analyses were done by standard methods. Performance status (PS) was assessed using the

Open access

Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou and Zubing Mei

representative GLP-1 RAs and DPP-4 inhibitors, respectively. Recently, several studies showed that adding liraglutide to insulin treatment in subjects with type 1 diabetes reduced glycosylated haemoglobin (HbA1c) and body weight, but these benefits were

Open access

Yuan Zhou, ShengNan Wang, Jing Wu, JianJun Dong and Lin Liao

, mild fasting hyperglycaemia named MODY2 ( 9 ). Clinical features of MODY2 include a non-progressive slight increase in glycated hemoglobin (HbA1c), usually between 5.6% and 7.6%, and mildly raised fasting glucose (usually between 5.4–8.3 mmol/L) ( 10