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Yongping Liu, Shuo Wang, Qingling Guo, Yongze Li, Jing Qin, Na Zhao, Yushu Li, Zhongyan Shan, and Weiping Teng

Introduction Hashimoto’s thyroiditis (HT), the most common type of thyroiditis and the most frequent cause of hypothyroidism ( 1 ), is characterized by high levels of thyroid auto-antibodies (antithyrogloblin antibody, TgAb and thyroperoxidase

Open access

Maria Giannakou, Katerina Saltiki, Emily Mantzou, Eleni Loukari, Georgios Philippou, Konstantinos Terzidis, Charalampos Stavrianos, Miltiades Kyprianou, Theodora Psaltopoulou, Kalliopi Karatzi, and Maria Alevizaki

antioxidants’ levels in these patients ( 20 , 21 , 22 , 23 , 24 , 25 , 26 ). Hashimoto’s thyroiditis (HT) is the most common autoimmune thyroid disease and it affects people of any age with an increased incidence in middle-aged women ( 27 , 28 ). Both

Open access

Xuan Luo, Tingting Zheng, Chaoming Mao, Xin Dong, Xiao Mou, Chengcheng Xu, Qingyan Lu, Baocui Liu, Shengjun Wang, and Yichuan Xiao

, the role of the MRP14 homodimer is not clear in Hashimoto’s thyroiditis (HT). HT is characterised by infiltration of thyroid-specific T lymphocytes and other immune cells, thyroid enlargement and fibrosis and progressive destruction of thyrocytes

Open access

Weiwei He, Bin Wang, Kaida Mu, Jing Zhang, Yanping Yang, Wei Yao, Sheli Li, and Jin-an Zhang

AITDs and disease progression ( 7 , 8 ). AITDs mainly have two types of symptoms, Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). HT is the most common thyroid inflammation characterized by abnormally elevated thyroglobulin antibodies (TGAb) and

Open access

Giorgio Radetti, Mariacarolina Salerno, Chiara Guzzetti, Marco Cappa, Andrea Corrias, Alessandra Cassio, Graziano Cesaretti, Roberto Gastaldi, Mario Rotondi, Fiorenzo Lupi, Antonio Fanolla, Giovanna Weber, and Sandro Loche

Introduction Hashimoto’s thyroiditis (HT) is a frequent autoimmune disease that may present with a spectrum of altered thyroid function ranging from thyrotoxicosis to overt hypothyroidism. Treatment with l -thyroxine ( l -T4) is commonly

Open access

Yun Cai, Jieni Yan, Yong Gu, Heng Chen, Yang Chen, Xinyu Xu, Mei Zhang, Liping Yu, Xuqin Zheng, and Tao Yang

Introduction Autoimmune thyroid disease (AITD) is a common organ-specific autoimmune disorder which includes two main clinical diseases: Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Both GD and HT share the immunologic manifestation

Open access

A Rouland, J-C Chauvet-Gelinier, A-L Sberna, E Crevisy, P Buffier, T Mouillot, J-M Petit, and B Vergès

assessment and compare the Type A profiles of patients with T1D and patients presenting with other auto-immune disease (Graves’ disease or Hashimoto’s thyroiditis), in order to validate the hypothesis that increased Type A personality traits is related to the

Open access

Xiaoya Zheng, Shanshan Yu, Jian Long, Qiang Wei, Liping Liu, Chun Liu, and Wei Ren

Objective: Both primary thyroid lymphoma (PTL) and diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) are two rare malignant tumours with different therapies and prognoses. This study compared their clinical features.

Methods: From a retrospective review of the pathologic database at our institute between January 2015 and August 2020, 52 PTL patients and 40 DSVPTC patients were included. Demographic, clinical, laboratory and ultrasound data were extracted from electronic medical records. Statistical analyses were performed using GraphPad Prism 5.0.

Results: Both PTL and DSVPTC were more likely to occur in women (83.7% and 67.5%), but DSVPTC patients were younger (median age: 36 vs 64.5), had fewer compressive symptoms, and more frequently had neck lymph node metastasis than PTL patients. The prevalence of Hashimoto’s thyroiditis (HT) and hypothyroidism was significantly higher in PTL patients than in DSVPTC patients (31% vs 17.5%). Hyperthyroidism could only be found in DSVPTC patients, which accounted for 7.5%. Heterogeneous echogenicity and irregular edges were frequently observed in both PTL and DSVPTC. However, compared with PTL, DSVPTC exhibited smaller lesion sizes, higher frequencies of diffuse sonographic patterns and calcification, and lower frequencies of hypoechoic features and internal blood flow signal. The overall survival rate with PTL was 77.23%, which was lower than that with DSVPTC (90.91%), but this difference was not significant (p=0.096).

Conclusion: Clinical characteristics such as age, compression symptoms, and sonographic features such as a large mass with heterogeneous echogenicity, hypoechoic, irregular edges, and calcification are helpful for impression diagnosis of PTL and DSVPTC before surgery.

Open access

Eugenie S Lim, Shanty G Shah, Mona Waterhouse, Scott Akker, William Drake, Nick Plowman, Daniel M Berney, Polly Richards, Ashok Adams, Ewa Nowosinska, Carmel Brennan, and Maralyn Druce

( 1 , 16 , 17 ). Separate reports have suggested that DTC, especially PTC with autoimmune thyroiditis, exhibit cytotoxic T-cell-mediated reactions ( 12 , 18 ). Therefore, Hashimoto’s thyroiditis may facilitate destruction of cancer cells and prevent

Open access

Aaron Lerner, Patricia Jeremias, and Torsten Matthias

Introduction Hashimoto's thyroiditis Hashimoto’s thyroiditis (HT) is one of the most common autoimmune endocrine diseases, characterized by an autoimmune-mediated destruction of the thyroid gland. Initially considered a rarity, HT has now