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David J F Smith, Hemanth Prabhudev, Sirazum Choudhury, and Karim Meeran

mineralocorticoid production in primary adrenal failure. The mainstay of treatment is glucocorticoid replacement, with either hydrocortisone or prednisolone ( 2 ). Both work by binding to the glucocorticoid receptor (GR) for which prednisolone has the greater

Open access

Sirazum Choudhury, Tricia Tan, Katharine Lazarus, and Karim Meeran

Introduction Between 1928 and 1938, patients with Addison’s disease had a 100% 5-year mortality ( 1 ). With the availability of glucocorticoid replacement therapy, initially with animal adrenocortical extract and later synthetic 11

Open access

Salem A Beshyah, Khawla F Ali, and Hussein F Saadi

preparation do you, most commonly, use for replacement therapy? (Hydrocortisone, Cortisone acetate, Prednisone/Prednisolone, Long-acting prednisolone, Dexamethasone).  4. How do you usually divide the daily dose of glucocorticoids used for replacement

Open access

Marcus Quinkler, Bertil Ekman, Claudio Marelli, Sharif Uddin, Pierre Zelissen, Robert D Murray, and on behalf of the EU-AIR Investigators

glucocorticoid replacement therapies ( 21 ). The primary objective of the EU-AIR is to monitor the safety of long-term treatment with once-daily modified-release hydrocortisone and other glucocorticoid replacement therapies in patients with AI. All enrolled

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Kathrin R Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf, and Marcus Quinkler

Introduction In states of adrenal insufficiency (AI), such as primary adrenal insufficiency (PAI) and congenital adrenal hyperplasia (CAH), glucocorticoids (GCs) are given in low doses as hormone replacement therapy. However, the daily intake

Open access

Stephanie Burger-Stritt, Linda Bachmann, Max Kurlbaum, and Stefanie Hahner

replacement at times of increased requirement. To avoid AC, patients are educated in adaptation of their glucocorticoid (GC) dose under stressful conditions ( 12 , 13 , 14 ). AC requires immediate initiation of parenteral administration of GCs ( 13 , 14

Open access

Anastasia P Athanasoulia-Kaspar, Matthias K Auer, Günter K Stalla, and Mira Jakovcevski

the dose of glucocorticoid replacement therapy. Correlation of adjusted pPCR values (Ct) with daily total hydrocortisone dose in NFPA patients with adrenal insufficiency ( n  = 52). Note, higher Cts are indicative of shorter telomeres. Pearson

Open access

Lia Ferreira, João Silva, Susana Garrido, Carlos Bello, Diana Oliveira, Hélder Simões, Isabel Paiva, Joana Guimarães, Marta Ferreira, Teresa Pereira, Rita Bettencourt-Silva, Ana Filipa Martins, Tiago Silva, Vera Fernandes, Maria Lopes Pereira, and Adrenal Tumors Study Group of the Portuguese Society of Endocrinology

, particularly regarding diagnosis, aetiology, concomitant autoimmune disorders, family history and replacement regimens, such as the type, daily dosage and dose frequency of glucocorticoids, as well as the use of mineralocorticoids. We assessed the occurrence of

Open access

Kathrin Zopf, Kathrin R Frey, Tina Kienitz, Manfred Ventz, Britta Bauer, and Marcus Quinkler

need a lifelong glucocorticoid replacement therapy ( 11 , 12 ), which needs to be tailored individually to the daily needs, to stress situations, and intercurrent illnesses such as infectious diseases ( 13 ). This is even more important since the daily

Open access

Wiebke Arlt and the Society for Endocrinology Clinical Committee

clinical recovery guided by an endocrinologist. In patients with primary adrenal insufficiency, mineralocorticoid replacement needs to be initiated (starting dose 100 micrograms fludrocortisone once daily) as soon as the daily glucocorticoid dose is below