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Marta Araujo-Castro, Héctor Pian, Ignacio Ruz-Caracuel, Alberto Acitores Cancela, Eider Pascual-Corrales, and Víctor Rodríguez Berrocal

, tumor consistency was reported to be an important predictive factor since hard consistency could impede transsphenoidal resection, especially in macroadenomas ( 8 ). Preoperative somatostatin receptor ligands (SRLs) treatment is proven to reduce GH and

Open access

Imane Benabbad, Myriam Rosilio, Maité Tauber, Emmanuel Paris, Anne Paulsen, Lovisa Berggren, Hiren Patel, Jean-Claude Carel, and the Phoenix Study Group

cause short stature have been excluded ( 1 ). Various studies have shown that growth hormone (GH) treatment of children with ISS can increase their growth velocity and, to a lesser extent, adult height ( 1 , 2 , 3 , 4 , 5 , 6 ). The effect on height

Open access

Ekaterina Koledova, George Stoyanov, Leroy Ovbude, and Peter S W Davies

Introduction Recombinant human growth hormone (GH) is approved for use in the treatment of children with various aetiologies, including growth hormone deficiency (GHD), Turner syndrome (TS) and born small for gestational age (SGA) with no

Open access

Elvira C Arellanes-Licea, José Ávila-Mendoza, Elizabeth C Ramírez-Martínez, Eugenia Ramos, Nancy Uribe-González, Carlos Arámburo, Teresa Morales, and Maricela Luna

serum GH increased significantly by lactation (40%) as compared to virgin rats ( P  < 0.05), and it increased further after KA treatment (72%, P  < 0.001 vs virgin rats). The two-way ANOVA confirmed that the reproductive condition affected the response

Open access

Thomas Reinehr, Martin Carlsson, Dionisios Chrysis, and Cecilia Camacho-Hübner

of GH treatment and adult height in children with GHD is lower compared to target height even though the children were treated adequately with growth hormone (GH) ( 13 ), we hypothesize that adult height prediction based on bone age will overestimate

Open access

Jin Kyu Oh, Young Jae Im, Kwanjin Park, and Jae-Seung Paick

prevented reductions of AR expression and enhanced penile fibroblast proliferation and testis growth, indicating a target for the treatment of micropenis ( 10 ). Hence, under conditions of normal GH and IGF1 activities, penile dimensions may be increased

Open access

Guillem Cuatrecasas, Hatice Kumru, M Josep Coves, and Joan Vidal

Injury level SCI etiology Peak GH (Glucagon test) (ng/mL) Low GH secretion Treatment group allocation 37 F 17 A Th 11 Bicycle accident 16 No No 24 M 13 A Th 11 Traffic accident 4.3 Yes GH 43

Open access

Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen, and on behalf of the Growth Hormone Research Society

endpoint in trials involving GH treatment and medical treatment of acromegaly, neither GH nor IGF-I has been subject to a structured evaluation as biomarkers, nor do we have a comprehensive definition of clinical endpoints for the treatment of GH

Open access

Charlotte Höybye, Andreas F H Pfeiffer, Diego Ferone, Jens Sandahl Christiansen, David Gilfoyle, Eva Dam Christoffersen, Eva Mortensen, Jonathan A Leff, and Michael Beckert

mid-1980s and is identical to endogenous GH. To date, AGHD standard-of-care treatment consists of daily subcutaneous GH injections. However, a significant portion of patients are poorly adherent to treatment ( 7 ), up to 65% in one study, attributed to

Open access

Charlotte Höybye, Erik Wahlström, Petra Tollet-Egnell, and Gunnar Norstedt

with healthy controls, and changes in metabolic profile during GH treatment and after discontinuation of GH replacement was observed. The aims of this study were to detect the levels of serum metabolome in GHD patients and healthy subjects and to find