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/or Kallmann syndrome (KS), such as midline cerebral and facial defects (3) . The adenohypophyseal and olfactory placodes share a common embryological origin as they both emerge from the preplacodal field, which could explain this overlap (4) . FGFR1, a
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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of FGF21 action. Adipose tissue-specific FGFR1 or β-klotho knockout abolishes FGF21 effects on glucose and energy regulation ( 9 , 10 ). Adiponectin, an insulin-sensitizing adipokine, has been shown as an effector of FGF21. Both acute and chronic FGF
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Departamento de Medicina, Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, Brasil
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Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular (LIM42), Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo (USP), Sao Paulo, Brasil
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Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular (LIM42), Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo (USP), Sao Paulo, Brasil
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Unidade de Endocrinologia do Desenvolvimento, Laboratorio de Hormonios e Genetica Molecular (LIM42), Hospital das Clinicas da Faculdade de Medicina, Universidade de Sao Paulo (USP), Sao Paulo, Brasil
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to the growth plate (four in IHH , two in NPR2 , two in FGFR3, one in ACAN , and one in COL2A1 ), one variant was in a gene associated with the GH–IGF1 axis ( GHSR ), and five variants were in genes related to the RAS-MAPK pathway (two in NF1
The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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The First Affiliated Hospital, Department of Endocrinology and Metabolism, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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of cancer cells via EMT. Mechanically, although most studies verified that FGF1 functions through FGF receptors (FGFRs) ( 15 ), in our study, we found that FGF1 promotes TC cell EMT independent of FGFR. Interestingly, we demonstrated that FGF1 could
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University Regional Hospital of Patras, Rio, Greece
Mount Auburn Hospital, Harvard Medical School Teaching Hospital, Cambridge, Massachusetts, USA
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such genes include ANOS1 – Anosmin 1, previously known as KAL1 – Kallmann 1, NSMF – NMDA receptor synaptonuclear signaling and neuronal migration factor, FGFR1 – fibroblast growth factor receptor 1 , FGF8 – fibroblast growth factor 8, FGF17
Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
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mediates a range of biological responses including development, wound healing, homeostasis and metabolism ( 14 ). Most FGFs, called canonical FGFs, interact with heparin or heparin sulfate glycosaminoglycans (HSGAGs) and then activate FGF receptors (FGFR1
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observed, while the liver-specific KLB KO display unaltered FGF21 sensitivity ( 74 ). The direct effect on liver may depend on the pharmacological dose ( 72 , 75 ), as FGF21 binds with higher affinity toward the FGFR1c/KLB complex compared to the FGFR3c
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regulates neuronal cell function, such as neurite branching, outgrowth, and migration through the activation of FGFR1 ( 30 , 31 ), and promotes angiogenesis through vascular endothelial growth factor (VEGFR)-related signaling as well as migration ( 32
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exert downstream signaling events ( 11 ). Studies have found that FGF23 exerts most of its physiologic functions through binding with FGFR1c ( 11 , 12 ). In renal proximal tubular epithelial cells, circulating FGF23 binds with the αKlotho/FGFR1c complex
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CHU Lille, Service de Biochimie Hormonologie, Métabolisme, Nutrition-Oncologie, Centre de Biologie Pathologie Génétique, Lille, France
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genes using the Illumina TruSeq Amplicon Cancer Panel ( ABL1 , AKT1 , ALK , APC , ATM , BRAF , CDH1 , CDKN2A , CSF1R , CTNNB1 , EGFR , ERBB2 , ERBB4 , FBXW7 , FGFR1 , FGFR2 , FGFR3 , FLT3 , GNA11 , GNAQ , GNAS , HNF1A , HRAS , IDH1