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Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
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Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Hong Kong, Hong Kong
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) family, FGF19 and FGF21, have been shown to be associated with obesity and diabetes ( 10 , 11 , 12 ). Moreover, serum FGF21 can predict the development of T2DM in the normal population, as well as being associated with incident coronary heart disease
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing Physiotherapy and Medicine, SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
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secreted by activated brown adipocytes, promotes thermogenesis through both UCP1-dependent and UCP1-independent mechanisms ( 18 , 19 ). Additionally, FGF21 is secreted by the liver in a process dependent on the action of peroxisome proliferator
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Diagnostic Clinic, University Hospital of North Norway, Tromso, Norway
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Division of Internal Medicine, University Hospital of North Norway, Tromso, Norway
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1,25(OH) 2 D, 24,25(OH) 2 D, DBP and FGF23 in 2016, free 25(OH)D in 2020, in addition to the 25(OH)D and PTH measured in 2012/2011. All participants <19 years with 25(OH)D levels ≥70 nmol/L or <20 nmol/L were included. In addition, a random sample of
Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
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. Recent clinical and animal studies have reported that FGF19 and FGF21 are associated with obesity and T2DM ( 2 , 3 ). FGF19 and FGF21 suppress triglyceride and glucose syntheses, meanwhile inducing glycogenesis and fatty acid oxidation in the liver
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Service of Endocrinology, Laboratory of Intensive Care, Department of Microbiology and Molecular Medicine, Diabetes, Hypertension and Nutrition
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Introduction Fibroblast growth factor 21 (FGF21) is a member of the FGF superfamily, consisting of FGF19, FGF21, and FGF23 (1, 2, 3, 4) . Because they lack the conventional FGF-heparin-binding domain, these FGFs can escape the body's vast
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.1210/en.2012-1193 22778214 22 Zhao Y Meng C Wang Y Huang H Liu W Zhang JF Zhao H Feng B Leung PS Xia Y . IL-1beta inhibits beta-klotho expression and FGF19 signaling in hepatocytes . American Journal of Physiology: Endocrinology and Metabolism 2016
The First Affiliated Hospital, Department of Otorhinolaryngology, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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The First Affiliated Hospital, Department of Endocrinology and Metabolism, Hengyang Medical School, University of South China, Hengyang, Hunan, China
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of FGF1 may halt disease progression. FGF1 is involved in the regulation of diverse physiological processes, such as development ( 18 ), angiogenesis ( 19 ), wound healing ( 20 ), adipogenesis ( 21 ), and neurogenesis ( 22 ), while dysfunction of
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark
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consequences of the APR or decrease assisting these changes to manifest remain unknown. Also, FGF21 was recently reported to improve the outcome of inflammation such as sepsis and pancreatitis in animal models ( 19 , 20 ). A way to mimic infection in healthy
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effects on the musculoskeletal system, the neuronal system, the immune system, and inflammatory pathways ( 1 , 4 , 34 , 62 , 63 , 64 , 65 , 66 ). FGF23 FGF23 is a member of the endocrine FGF family, along with FGF19 and FGF21 ( 9
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Central Laboratory, University Hospital Würzburg, Würzburg, Germany
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(insufficient vasopressin (AVP) secretion from the pituitary ( 2 , 3 , 4 )), the cause of primary polydipsia (with excessive fluid intake often without obvious cause) remains unclear. Fibroblast growth factor 21 (FGF-21) is a peptide hormone synthesized by