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Bo Zhu, Yumei Chen, Fang Xu, Xiaolu Shen, Xuanyu Chen, Jieqiang Lv, and Songying Zhang

etiology of PCOS is complex and unclear, recent studies reveal that androgens excess and endoplasmic reticulum (ER) stress play important roles in the progression and pathogenesis of PCOS ( 7 , 8 , 9 ). Clinical studies showed that hyperandrogenism is

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Selina Mäkinen, Yen H Nguyen, Paulina Skrobuk, and Heikki A Koistinen

). GSK-3β Palmitate led to a decrease in insulin-stimulated GSK3β phosphorylation, which was recovered by co-incubation with oleate ( Fig. 1C ). ER stress and AMPK signalling PERK Incubation with palmitate for 12 h induced ER stress as

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María J Gómora, Flavia Morales-Vásquez, Enrique Pedernera, Delia Perez-Montiel, Horacio López-Basave, Antonio R Villa, Azucena Hernández-Martínez, Esteban Mena, and Carmen Mendez

triple positive receptor and the highest frequency of ER suggesting being a neoplasm responsive to hormones. Additionally, evidence of enzymes involved in steroid hormone metabolism in stromal cells of ovarian carcinoma ( 29 , 30 ), stresses the probable

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Greta B Raglan, Louis A Schmidt, and Jay Schulkin

Introduction Stress reactions are by no means universal, and the activation of ‘stress hormones’, such as glucocorticoids or corticotropin-releasing hormone (CRH), is not necessarily the mark of a stress response ( 1 ). Some individuals have

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Andrew R Dismukes, Vanessa J Meyer, Elizabeth A Shirtcliff, Katherine P Theall, Kyle C Esteves, and Stacy S Drury

fluctuates in response to social stressors ( 2 ). Unlike other steroid hormones that have specific receptors, DHEA binds to a range of receptors, including the estrogen receptor ( 3 ). DHEA serves as a prohormone for estrogen and testosterone and can broadly

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Hathairat Rueangdetnarong, Rattanaporn Sekararithi, Thidarat Jaiwongkam, Sirinart Kumfu, Nipon Chattipakorn, Theera Tongsong, and Phudit Jatavan

induced by hormonal change during pregnancy probably plays an important role of clinical manifestation. GDM may probably be related to oxidative stress in insulin resistance pathway, as documented in DM type 2 ( 10 ). Nevertheless, the relationship between

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Xiuzhen Hou, Junfeng Zhang, Hehong Ma, Ming Li, and Pei Wang

) production and metabolic rate. Therefore, pregnancy is regarded as a pre-diabetic state with greater oxidative stress ( 11 , 12 ). Oxidative stress, which is among the major factors contributing to the diabetes pathogenesis, exerts crucial functions in the

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Masatada Watanabe, Shuji Ohno, and Hiroshi Wachi

relationship between atopic dermatitis and stress in human skin tissue. Recent studies also suggest a relationship between stress and atopic dermatitis. In an investigation of the stress response, which was determined by the measurement of salivary cortisol

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Rachel K Rowe, Benjamin M Rumney, Hazel G May, Paska Permana, P David Adelson, S Mitchell Harman, Jonathan Lifshitz, and Theresa C Thomas

injury severity spectrum ( 15 ). Injury-induced endocrine dysfunction can be concomitant with and potentially augment clinical symptoms commonly associated with postconcussive syndrome and post-traumatic stress disorder (PTSD) ( 22 , 29 ). While the

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Legh Wilkinson, Nicolette J D Verhoog, and Ann Louw

. ( ) 146 Yemelyanov A Bhalla P Yang X Ugolkov A Iwadate K Karseladze A Budunova I. Differential targeting of androgen and glucocorticoid receptors induces ER stress and apoptosis in prostate cancer cells: a novel