Nicolai J Wewer Albrechtsen
Nicolai J Wewer Albrechtsen
NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
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Monika J Bak
Monika J Bak
NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
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NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
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Bolette Hartmann
Bolette Hartmann
NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
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Louise Wulff Christensen
Louise Wulff Christensen
NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
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Rune E Kuhre
Rune E Kuhre
NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
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Carolyn F Deacon
Carolyn F Deacon
NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
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Jens J Holst
Jens J Holst
NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, Department of Science, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 12.2, DK‐2200 Copenhagen N, Denmark
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20 min at 2261 g at 4 °C. Plasma was separated immediately and pooled. Next, aprotinin (Trasylol 10000 KIE/ml; Bayer Health Care AG 51368; final concentration 500 KIE/ml) and a DPP4 inhibitor (valine pyrrolidide, a gift from Novo Nordisk A
Xiao-jun Zhou
Xiao-jun Zhou
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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Lin Ding
Lin Ding
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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Jia-xin Liu
Jia-xin Liu
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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Le-qun Su
Le-qun Su
Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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Jian-jun Dong
Jian-jun Dong
Division of Endocrinology, Department of Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China
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Lin Liao
Lin Liao
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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glycemic control remains around 50% in the United States ( 3 ) and 39.7% in China ( 4 ). Dipeptidyl peptidase-4 (DPP-4) inhibitors, characterized by low propensity of hypoglycemia and weight neutrality, have gradually become an important class in the
Lili Liu
Lili Liu
Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Zhuo Shao
Zhuo Shao
Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, Shanghai, China
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Ying Xia
Ying Xia
Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Jiabi Qin
Jiabi Qin
Department of Epidemiology & Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China
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Yang Xiao
Yang Xiao
Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Zhiguang Zhou
Zhiguang Zhou
Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Zubing Mei
Zubing Mei
Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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. Incretin-based drugs, including glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase 4 (DPP-4) inhibitors, may offer an opportunity to avoid these side effects. Theoretically, GLP-1 RAs are structurally and functionally similar to
Shenghe Luo
Shenghe Luo
College of Pharmacy, Yanbian University, Yanji, China
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Yunhui Zuo
Yunhui Zuo
Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji, China
Department of Cardiology, Yanbian University Hospital, Yanji, China
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Department of Cardiology, Yanbian University Hospital, Yanji, China
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Xiaotian Cui
Xiaotian Cui
Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji, China
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Meiping Zhang
Meiping Zhang
Department of Cardiology, Yanbian University Hospital, Yanji, China
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Honghua Jin
Honghua Jin
Department of Pharmacy, Yanbian University Hospital, Yanji, China
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Lan Hong
Lan Hong
Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji, China
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, liraglutide: GLP-1R agonist, 3.2 nmol/L; Exendin9-39: GLP-1R antagonist, 0.3 nmol/L. WT, WT (wild-type) mouse + saline (30 μg/kg); WT + Li, WT mouse + liraglutide (30 μg/kg); DPP-4 −/− , DPP-4 −/− mouse (inhibiting consumption of endogenous GLP-1) + saline
Zhenyu Liu
Zhenyu Liu
Department of Clinical Medicine, Beijing Luhe Hospital, Capital Medical University, Tongzhou District, Beijing, China
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Huixi Kong
Huixi Kong
Department of Clinical Medicine, Beijing Shijitan Hospital, Capital Medical University, Haidian District, Beijing, China
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Baoyu Zhang
Baoyu Zhang
Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Tongzhou District, Beijing, China
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: those that increase insulin secretion and those that rely on other mechanisms. The former drugs mainly include sulfonylureas, meglitinides, dipeptidyl peptidase-4 inhibitors (DPP-4i), whereas the latter drugs that lower blood sugar through other
Lizhi Zhang
Lizhi Zhang
Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
Department of Endocrinology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Department of Endocrinology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Jinwei He
Jinwei He
Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
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Xiang Sun
Xiang Sun
Shanghai Institute of Technology, Shanghai, China
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Dongyue Pang
Dongyue Pang
Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
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Jingjing Hu
Jingjing Hu
Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
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Bo Feng
Bo Feng
Department of Endocrinology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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). Some drugs commonly used to regulate blood sugar, such as glucagon-like peptide-1 (GLP-1) receptor agonists and DPP-4 inhibitors (DPP-4is), can inhibit bone resorption and improve bone formation ( 2 , 3 , 4 , 5 , 6 , 7 ). GLP-1 is a DPP-4 substrate
Giuseppe Lisco
Giuseppe Lisco
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Anna De Tullio
Anna De Tullio
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Olga Disoteo
Olga Disoteo
Diabetology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy
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Giuseppina Piazzolla
Giuseppina Piazzolla
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Edoardo Guastamacchia
Edoardo Guastamacchia
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Carlo Sabbà
Carlo Sabbà
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Vincenzo De Geronimo
Vincenzo De Geronimo
Unit of Endocrinology, Policlinico Morgagni CCD, Catania, Italy
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Enrico Papini
Enrico Papini
Department of Endocrinology and Metabolism, Regina Apostolorum Hospital, Rome, Italy
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Vincenzo Triggiani
Vincenzo Triggiani
Interdisciplinary Department of Medicine, Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, School of Medicine, University of Bari “Aldo Moro”, Piazza Giulio Cesare, Bari, Italy
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Z & You Z . DPP4 gene silencing inhibits proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through suppression of the MAPK pathway . Journal of Endocrinological Investigation 2021 44 1609 – 1623 . ( https
Jothydev Kesavadev
Jothydev Kesavadev
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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Pradeep Babu Sadasivan Pillai
Pradeep Babu Sadasivan Pillai
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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Arun Shankar
Arun Shankar
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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Gopika Krishnan
Gopika Krishnan
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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Sunitha Jothydev
Sunitha Jothydev
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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, many patients will eventually require to be shifted to another class of oral antidiabetic agents or insulin therapy ( 2 , 3 ). DPP-4 inhibitors are a class of oral antidiabetic drugs which enhance the function of endogenous incretin and help with
Merlin C Thomas
Merlin C Thomas
Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia
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Brendon L Neuen
Brendon L Neuen
The George Institute for Global Health, Sydney, NSW, Australia
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Stephen M Twigg
Stephen M Twigg
The University of Sydney School of Medicine, Sydney, NSW, Australia
Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
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Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
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Mark E Cooper
Mark E Cooper
Department of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia
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Sunil V Badve
Sunil V Badve
The George Institute for Global Health, Sydney, NSW, Australia
Department of Renal Medicine, St George Hospital, Sydney, NSW, Australia
Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia
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Department of Renal Medicine, St George Hospital, Sydney, NSW, Australia
Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia
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with T2D from two commercial and Medicare databases in the USA (2014–2019) – compared empagliflozin therapy with dipeptidyl peptidase-4 (DPP-4) inhibitor and glucagon-like peptide-1 receptor agonist (GLP1 RA) therapy, with a CV composite primary outcome
Chun-feng Lu
Chun-feng Lu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Wang-shu Liu
Wang-shu Liu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Xiao-qin Ge
Xiao-qin Ge
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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Feng Xu
Feng Xu
Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China
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statins among the tertiles of ADA levels ( P for trend < 0.05). However, BMI, diastolic blood pressure (DBP), use of insulin secretagogues and dipeptidyl peptidase 4 (DPP-4) inhibitors, antihypertensive treatments, lipid profile, BUN level, and Cr level
