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Boni Xiang, Ran Tao, Xinhua Liu, Xiaoming Zhu, Min He, Zengyi Ma, Yehong Yang, Zhaoyun Zhang, Yiming Li, Zhenwei Yao, Yongfei Wang and Hongying Ye

Introduction Cushing’s syndrome (CS) comprises diverse manifestations resulting from chronic exposure to excess glucocorticoids. The incidence is 0.2–5.0 per million people per year. Approximately 80% of endogenous CS is adrenocorticotrophin

Open access

M S Elston, V B Crawford, M Swarbrick, M S Dray, M Head and J V Conaglen

* Died shortly after first dose. AdenoCa, prostate adenocarcinoma; CS, Cushing’s syndrome; dx, diagnosis; hx, history; MR, mineralocorticoid. Of the reported cases of CS associated with SCPC most are due to ectopic ACTH production ( 24

Open access

Jingya Zhou, Meng Zhang, Lin Lu, Xiaopeng Guo, Lu Gao, Weigang Yan, Haiyu Pang, Yi Wang and Bing Xing

Introduction Endogenous Cushing’s syndrome (CS) comprises signs and symptoms caused by pathological hypercortisolism, which seriously affects the metabolic and endocrine systems. Endogenous CS is divided between adrenocorticotropic hormone

Open access

Soraya Puglisi, Paola Perotti, Mattia Barbot, Paolo Cosio, Carla Scaroni, Antonio Stigliano, Pina Lardo, Valentina Morelli, Elisa Polledri, Iacopo Chiodini, Giuseppe Reimondo, Anna Pia and Massimo Terzolo

Introduction Cushing’s syndrome (CS) is a condition of endogenous hypercortisolism caused by different pathological entities that is classified in two variants: (i) ACTH-dependent CS, due to a corticotroph pituitary adenoma or an ectopic tumor

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Carla Scaroni, Nora M Albiger, Serena Palmieri, Davide Iacuaniello, Chiara Graziadio, Luca Damiani, Marialuisa Zilio, Antonio Stigliano, Annamaria Colao, Rosario Pivonello and the Altogether to Beat Cushing’s Syndrome (ABC) study group

( 2 ). Under such conditions, there may be some clinical signs of hypercortisolism, which may be temporary or more persistent, giving rise to what is called pseudo-Cushing’s syndrome (PCS). The differential diagnosis of PCS and Cushing’s syndrome (CS

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Benedetta Zampetti, Erika Grossrubatscher, Paolo Dalino Ciaramella, Edoardo Boccardi and Paola Loli

ACTH-dependent hypercortisolism is highly suggestive of pituitary disease, this is not true for smaller lesions that still might be incidentaloma ( 16 , 17 ). The Consensus Statement on Diagnosis and Complications of Cushing’s Syndrome suggests 6mm as

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Kush Dev Singh Jarial, Anil Bhansali, Vivek Gupta, Paramjeet Singh, Kanchan K Mukherjee, Akhilesh Sharma, Rakesh K Vashishtha, Suja P Sukumar, Naresh Sachdeva and Rama Walia

Introduction The differential diagnosis of ACTH-dependent Cushing’s syndrome (CS) as pituitary or ectopic source of ACTH production is often challenging for the physicians as none of the biochemical tests or imaging modalities have 100

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Alberto Giacinto Ambrogio, Massimiliano Andrioli, Martina De Martin, Francesco Cavagnini and Francesca Pecori Giraldi

Pathophysiology of the Hypothalamic-Pituitary-Adrenal Axis. Diagnosis and management of Cushing’s syndrome: results of an Italian multicentre study . Journal of Clinical Endocrinology and Metabolism 1999 84 440 – 448 . ( doi:10.1210/jcem.84.2.5465 ) 5

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Bjørn O Åsvold, Valdemar Grill, Ketil Thorstensen and Marit R Bjørgaas

.1016/0006-3223(92)90086-F ). 9 Elamin MB Murad MH Mullan R Erickson D Harris K Nadeem S Ennis R Erwin PJ Montori VM . Accuracy of diagnostic tests for Cushing's syndrome: a systematic review and metaanalyses . Journal of Clinical Endocrinology and

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Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant and Agnès Linglart

Introduction Cushing’s disease (CD) is characterized by adrenocorticotropin (ACTH)-dependent cortisol excess originating from a pituitary adenoma and accounts for approximately 85% of cases of pediatric Cushing’s syndrome ( 1 , 2 , 3 , 4