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Changjiao Yan, Meiling Huang, Xin Li, Ting Wang and Rui Ling

stratification of PTC ( 5 ). BRAF is the main subtype of RAF kinase and plays a key role in tumorigenesis. The mutation of BRAF V600E could trigger tumorigenesis through constitutively activating MAPK pathway ( 6 ). As the most common mutation observed in

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Ana P Estrada-Flórez, Mabel E Bohórquez, Alejandro Vélez, Carlos S Duque, Jorge H Donado, Gilbert Mateus, Cesar Panqueba-Tarazona, Guadalupe Polanco-Echeverry, Ruta Sahasrabudhe, Magdalena Echeverry and Luis G Carvajal-Carmona

molecular makers in PTC etiology and prognosis. Given the significant worldwide increase in PTC incidence ( 8 ), there is a great need to identify prognosis biomarkers that allow for effective patient stratification and management. The BRAF V600E

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Klaudia Zajkowska, Janusz Kopczyński, Stanisław Góźdź and Aldona Kowalska

was 77.8% (21,667 out of 27,866). Molecular pathogenesis of NIFTP At the molecular level, NIFTP is characterised by the lack of BRAF V600E and BRAF V600E-like mutations or other high-risk mutations and a high rate of RAS mutations. This

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Barbora Pekova, Sarka Dvorakova, Vlasta Sykorova, Gabriela Vacinova, Eliska Vaclavikova, Jitka Moravcova, Rami Katra, Petr Vlcek, Pavla Sykorova, Daniela Kodetova, Josef Vcelak and Bela Bendlova

detection rate of mutations in the cohort of benign tissues was 5/30 and in the cohort of PTCs was 35/83, of which RET/PTC rearrangement (18/83), BRAF V600E mutation (15/83) and RAS mutations (2/83) were identified ( Fig. 1 ). All mutations in benign

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Ana Carolina de Jesus Paniza, Thais Biude Mendes, Matheus Duarte Borges Viana, Débora Mota Dias Thomaz, Paula B O Chiappini, Gabriel A Colozza-Gama, Susan Chow Lindsey, Marcos Brasilino de Carvalho, Venâncio Avancini Ferreira Alves, Otavio Curioni, André Uchimura Bastos and Janete Maria Cerutti

HRAS ) are the most prevalent mutations found in NIFTP. PAX8/PPARG and THADA fusions and EIF2AX and BRAF K601 mutations were recently described in a small portion of NIFTPs ( 30 , 31 ). The presence of the BRAF-V600E mutation may be a hint toward

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Guoquan Zhu, Yuying Deng, Liqin Pan, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang, Yanying Chen and Jiaxin Luo

metastasis. In recent years, an increasing number of molecular genetic characteristics associated with invasiveness and clinical management have been uncovered, including the BRAF V600E mutation, TERT promoter mutations, RAS mutations and RET

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Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi and Lewis Hassell

pathogenesis in PTC. Several genetic alterations have been described in PTC ( 4 ). Among them, BRAF mutation, especially BRAF V600E , is the most common mutation in PTC; however, its prognostic role in PTC is still debated ( 5 , 6 , 7 ). Another recently

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Lauren E Henke, John D Pfeifer, Thomas J Baranski, Todd DeWees and Perry W Grigsby

1164 – 1170 . ( https://doi.org/10.1001/jamaoto.2013.4501 ) 19 Xing M Alzahrani AS Carson KA Viola D Elisei R Bendlova B Yip L Mian C Vianello F Tuttle RM , Association between BRAF V600E mutation and mortality in patients with papillary thyroid

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Catarina Tavares, Maria João Coelho, Catarina Eloy, Miguel Melo, Adriana Gaspar da Rocha, Ana Pestana, Rui Batista, Luciana Bueno Ferreira, Elisabete Rios, Samia Selmi-Ruby, Bruno Cavadas, Luísa Pereira, Manuel Sobrinho Simões and Paula Soares

understood, but some studies demonstrated that both mRNA and protein are differentially expressed according to the genetic background of the tumor. In fact, papillary thyroid carcinomas (PTCs) harboring the BRAF V600E mutation present lower SLC5A5 mRNA and

Open access

Tiemo S Gerber, Arno Schad, Nils Hartmann, Erik Springer, Ulrich Zechner and Thomas J Musholt

of the percentage of malignant cells (tumour cell to non-tumour cell). An overview of the patient data is presented in Table 1 . Routine Sanger sequencing was performed on the BRAF V600E and BRAF wild-type V600 gene locus. Table 1