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Tatiana V Novoselova, Peter J King, Leonardo Guasti, Louise A Metherell, Adrian J L Clark, and Li F Chan

(PVN) secrete corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) ( 1 ) into the hypophyseal portal circulation, and these act on anterior pituitary corticotroph cells to trigger secretion of adrenocorticotropic hormone (ACTH) ( 2 , 3

Open access

Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, and Christopher J Kenyon

Introduction Temporal control of adrenocortical responses to ACTH involves several processes, mediated by a common signalling system. In vivo and in vitro studies show that within five minutes, stress and ACTH cause increased adrenal

Open access

Pablo Abellán-Galiana, Carmen Fajardo-Montañana, Pedro Riesgo-Suárez, Marcelino Pérez-Bermejo, Celia Ríos-Pérez, and José Gómez-Vela

two tests, it is necessary to take into account if glucocorticoids are used in the perioperative period. Few series have analyzed the usefulness of plasma ACTH after surgery as a prognostic indicator in CD, and the number of patients studied has

Open access

Hershel Raff and Hariprasad Trivedi

catheter was placed. Blood was sampled for plasma cortisol every 2 h from 0800 to 0600 h the following morning. Additional testing for plasma ACTH was done from blood drawn at 0800, 1200, 1800, 2200, 2400, and 0600 h. Salivary samples for cortisol were

Open access

Benedetta Zampetti, Erika Grossrubatscher, Paolo Dalino Ciaramella, Edoardo Boccardi, and Paola Loli

Introduction The differentiation among different causes of ACTH-dependent hypercortisolism is crucial to establish a proper treatment for this condition; the minority of patients with ectopic ACTH secretion (EAS) must be distinguished from the

Open access

Takuhiro Sonoyama, Masakatsu Sone, Naohisa Tamura, Kyoko Honda, Daisuke Taura, Katsutoshi Kojima, Yorihide Fukuda, Naotetsu Kanamoto, Masako Miura, Akihiro Yasoda, Hiroshi Arai, Hiroshi Itoh, and Kazuwa Nakao

known to stimulate aldosterone production by increasing the transcription of CYP11B2, the key steroidogenic enzyme of aldosterone synthesis. ACTH is also reported to stimulate aldosterone secretion, although its effects on aldosterone under normal

Open access

Filippo Ceccato, Diego Cecchin, Michele Gregianin, Giacomo Ricci, Cristina Campi, Filippo Crimì, Marta Bergamo, Annibale Versari, Carmelo Lacognata, Federico Rea, Mattia Barbot, and Carla Scaroni

Introduction Cushing’s syndrome (CS), characterized by excessive endogenous cortisol secretion, is in most cases ACTH-dependent. Corticotropin (ACTH) secretion arises from a pituitary adenoma (Cushing’s disease) or, less frequently, from a non

Open access

Lisa Arnetz, Neda Rajamand Ekberg, Kerstin Brismar, and Michael Alvarsson

have used the standard 250 μg adrenocorticotropic hormone (ACTH) stimulation test and the 1 mg dexamethasone test of feedback inhibition to evaluate the HPA axis. However, the 250 μg test induces supraphysiological ACTH levels, and may therefore not be

Open access

Majunath R Goroshi, Swati S Jadhav, Anurag R Lila, Rajeev Kasaliwal, Shruti Khare, Chaitanya G Yerawar, Priya Hira, Uday Phadke, Hina Shah, Vikram R Lele, Gaurav Malhotra, Tushar Bandgar, and Nalini S Shah

Introduction Ectopic adrenocorticotrophic hormone (ACTH) syndrome (EAS) is a rare disorder, accounting for 5–15% cases of endogenous Cushing’s syndrome (CS) ( 1 , 2 ). Although initially construed to be caused by malignant tumours (such as

Open access

Kush Dev Singh Jarial, Anil Bhansali, Vivek Gupta, Paramjeet Singh, Kanchan K Mukherjee, Akhilesh Sharma, Rakesh K Vashishtha, Suja P Sukumar, Naresh Sachdeva, and Rama Walia

Introduction The differential diagnosis of ACTH-dependent Cushing’s syndrome (CS) as pituitary or ectopic source of ACTH production is often challenging for the physicians as none of the biochemical tests or imaging modalities have 100