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Roberto Cosimo Melcangi, Livio Casarini, Marco Marino, Daniele Santi, Samantha Sperduti, Silvia Giatti, Silvia Diviccaro, Maria Grimoldi, Donatella Caruso, Guido Cavaletti, and Manuela Simoni

Introduction Finasteride is an inhibitor of 5 alpha-reductase (5α-R) type 1 and 2 enzymes, encoded by the SRD5A1 and SRD5A2 gene, respectively, with higher affinity for 5α-R type 2 in the human ( 1 , 2 ). This enzyme converts testosterone

Open access

Britt J van Keulen, Conor V Dolan, Bibian van der Voorn, Ruth Andrew, Brian R Walker, Hilleke Hulshoff Pol, Dorret I Boomsma, Joost Rotteveel, and Martijn J J Finken

. ( https://doi.org/10.1046/j.1365-2265.2000.00874.x ) 21 Yokoi H Tsuruo Y Miyamoto T Ishimura K . Steroid 5 alpha-reductase type 1 immunolocalized in the adrenal gland of normal, gonadectomized, and sex hormone-supplemented rats. Histochemistry

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I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder, and K Svechnikov

. Endocrinology 2003 144 575 – 580 . ( doi:10.1210/en.2002-220721 ) 11 Mahendroo M Wilson JD Richardson JA Auchus RJ. Steroid 5alpha-reductase 1 promotes 5α-androstane-3α,17β-diol synthesis in immature mouse testes by two pathways

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Lianghui You, Yan Wang, Yao Gao, Xingyun Wang, Xianwei Cui, Yanyan Zhang, Lingxia Pang, Chenbo Ji, Xirong Guo, and Xia Chi

affected by miR-23b-5p overexpression, thus participating in sustaining thermogenesis. qPCR results showed expression levels of these genes decreased after miR-23b-5p overexpression including AMP-activated protein kinase alpha 1 catalytic subunit ( Ampka1

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Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, and Christopher J Kenyon

. Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase . Journal of Steroid Biochemistry and Molecular Biology 2005 93 269

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A Daniel Bird, Spencer Greatorex, David Reser, Gareth G Lavery, and Timothy J Cole

alpha-reductase yielding 11beta-hydroxy-5alpha-androstanedione . Journal of Steroid Biochemistry and Molecular Biology 2013 138 132 – 142 . ( doi:10.1016/j.jsbmb.2013.04.010 ) 10.1016/j.jsbmb.2013.04.010

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Yao Chen and Shu-ying Fang

complicated and ambiguous pathogenesis. Many risk factors have been identified, such as obesity, genetics and early childhood growth patterns ( 4 , 5 ). Data from many studies suggest that genetics is very important in the development of PCOS. A Dutch twin

Open access

Zofia Kolesinska, James Acierno Jr, S Faisal Ahmed, Cheng Xu, Karina Kapczuk, Anna Skorczyk-Werner, Hanna Mikos, Aleksandra Rojek, Andreas Massouras, Maciej R Krawczynski, Nelly Pitteloud, and Marek Niedziela

 LHCGR Leydig cell hypoplasia AR 2p16.3 152790  POR P450 oxidoreductase deficiency AR 7q11.23 124015  SRD5A2 5α-reductase deficiency AR 2p23.1 607306  STAR Lipoid congenital adrenal hyperplasia AR 8p11

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Helle Keinicke, Gao Sun, Caroline M Junker Mentzel, Merete Fredholm, Linu Mary John, Birgitte Andersen, Kirsten Raun, and Marina Kjaergaard

biosynthesis. Cholesterol 7-alpha-monooxygenase ( Cyp7a1 ), mediating the rate-limiting step in BA synthesis, was upregulated, together with sterol 12-alpha-hydroxylase ( Cyp8b1 ) and the cholesterol transporters Sterolin-1 ( Abcg5 ) and sterolin-2 ( Abcg8

Open access

Letícia Ribeiro Oliveira, Carlos Alberto Longui, Guilherme Guaragna-Filho, José Luiz Costa, Rafael Lanaro, David Antônio Silva, Maria Izabel Chiamolera, Maricilda Palandi de Mello, André Moreno Morcillo, Andrea Trevas Maciel-Guerra, and Gil Guerra-Junior

MB Steinmetz L Damiani D Maciel-Guerra AT et al . Diagnosis of 5alpha-reductase type 2 deficiency: contribution of anti-Müllerian hormone evaluation . Journal of Pediatric Endocrinology and Metabolism 2005 18 1383 – 1389 . ( https