Sandra Pereira
Sandra Pereira
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Jessy Moore
Jessy Moore
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Jia-Xu Li
Jia-Xu Li
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Wen Qin Yu
Wen Qin Yu
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Husam Ghanim
Husam Ghanim
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA
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Filip Vlavcheski
Filip Vlavcheski
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Yemisi Deborah Joseph
Yemisi Deborah Joseph
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
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Paresh Dandona
Paresh Dandona
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo, Kaleida Health, Buffalo, New York, USA
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Allen Volchuk
Allen Volchuk
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
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Carolyn L Cummins
Carolyn L Cummins
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
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Evangelia Tsiani
Evangelia Tsiani
Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada
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Adria Giacca
Adria Giacca
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
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evidenced by an elevation in markers of unfolded protein response activation in the liver ( 6 ). Chemical chaperones that reduced ER stress, such as 4-phenylbutyric acid (PBA) and taurine-conjugated ursodeoxycholic acid (TUDCA), have been used in rodent
Qing Zhou
Qing Zhou
Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China
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Li Yong Zhang
Li Yong Zhang
Department of Thyroid Surgery, Minimal Invasive Center, Fujian Medical University Union Hospital, Fuzhou, China
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Mei Feng Dai
Mei Feng Dai
Department of Clinical Lab, Fujian Maternity and Child Health Hospital, Fuzhou, China
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Zhen Li
Zhen Li
Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China
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Chao Chun Zou
Chao Chun Zou
Department of Endocrinology, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Hui Liu
Hui Liu
Department of Endocrinology, Fujian Maternity and Child Health Hospital, Fujian Children’s Hospital, Fuzhou, China
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thyrotropic hormone was prepared by dissolving 10 μg of TSH in double distilled water to a final concentration of 5 mIU/L. Phenylbutyric acid (4-PBA) was obtained from MERCK (Beijing, China). Western blot reagents were obtained from Cell Signaling Technology
Wenrui Wang
Wenrui Wang
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China
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Chuan Zhang
Chuan Zhang
Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China
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protein folding, and modulate the UPR signaling pathway. These processes may provide targets for future drug candidates such as chemical chaperone molecules 4-phenylbutyric acid and taurine-deoxycholic acid to promote correct protein folding and cellular
