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Michael J Gratz, Stavroula Stavrou, Christina Kuhn, Simone Hofmann, Kerstin Hermelink, Helene Heidegger, Stefan Hutter, Doris Mayr, Sven Mahner, Udo Jeschke and Aurelia Vattai

% foetal cow serum. After 4 h, medium was changed to pure DMEM. The cells were stimulated with 0.01 nM or 0.1 nM thyronamine (T 0 AM) (Sigma-Aldrich, catalogue-ID: 80345), 3-iodothyronamine (T 1 AM) (Cayman Chemical) and RO5203548 (Glixx Laboratories

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Stavroula Stavrou, Michael Gratz, Eileen Tremmel, Christina Kuhn, Simone Hofmann, Helene Heidegger, Mina Peryanova, Kerstin Hermelink, Stefan Hutter, Bettina Toth, Doris Mayr, Sven Mahner, Udo Jeschke and Aurelia Vattai

, such as trace amines, common biogenic amines, amphetamine-like stimulants and 3-iodothyronamine can activate TAAR1 ( 18 , 19 , 20 ). The only known TAAR1 antagonist to date is RO5212773 (EPPTB) ( 21 ). TAAR1 has so far been investigated in the field

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Peter Wolf, Yvonne Winhofer, Martin Krššák and Michael Krebs

, hyperthyroidism and activation of the sympathetic nervous system share many cardio-stimulatory effects including tachycardia and increased contractility resulting in an increase in metabolic demand. Recent evidence suggests that 3-iodothyronamine, which is a