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Konstantin Yakimchuk Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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Chandrashekar Bangalore Revanna Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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Dan Huang Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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Jose Inzunza Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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Sam Okret Department of Biosciences and Nutrition Karolinska Institutet, Neo, Huddinge, Sweden

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line with our results, genistein was suggested to have a chemotherapy-potentiating effect by enhancing the anti-proliferative activity of a combination of cytostatic drugs on DLBCL cells in vitro and in a xenograft mouse model of DLBCL ( 34 ). These

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0459
Volume/Issue:
Volume 7: Issue 12
Open access
Jiwen Yang Department of Nuclear Medicine, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, China

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Yayin Huang Department of Clinical Laboratory, The Second People’s Hospital of Wuhu, Wuhu City, Anhui Province, China

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Bohan Dong Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu City, Anhui Province, China

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Yunhai Dai Department of Nuclear Medicine, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, China

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TNFAIP8 3’ UTR was constructed into the reporter vector. The validation of the combination between TNFAIP8 and miR-205-5p was conducted following the same approach. Murine xenograft assay Nude mice purchased from Beijing Vital River Laboratory

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0046
Volume/Issue:
Volume 10: Issue 4
Open access
Satoshi Inoue Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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Taichi Mizushima Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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Hiroki Ide Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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Guiyang Jiang Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA

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Takuro Goto Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA

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Yujiro Nagata Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA

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George J Netto Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA

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Hiroshi Miyamoto Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York, USA
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Department of Urology, University of Rochester Medical Center, Rochester, New York, USA

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’s correlation coefficient (CC). The rates of xenograft tumor formation and patient survival were calculated by the Kaplan–Meier method and comparison was made by log-rank test. The Cox proportional hazards model was used to determine statistical significance of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0364
Volume/Issue:
Volume 7: Issue 12
Open access
Carina Hasenoehrl Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria

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Gert Schwach Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria

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Nassim Ghaffari-Tabrizi-Wizsy Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
SFL Chicken CAM Lab, Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria

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Robert Fuchs Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria

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Nadine Kretschmer Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria

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Rudolf Bauer Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria

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Roswitha Pfragner Institute of Pathophysiology and Immunology, Center of Molecular Medicine, Medical University of Graz, Graz, Austria

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 mm silicon ring on the surface of the chorioallantoic membrane (CAM). Xenografts were treated topically every day, either with 2.2 µM shikonin (2 × IC 50 ) in 10 μL PBS ( n  = 9) or with 0.02% DMSO in PBS ( n  = 12) for 3 days. On day 4 after seeding

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0105
Volume/Issue:
Volume 6: Issue 2
Open access
Jan-Bernd Stukenborg NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Kirsi Jahnukainen NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden
Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Marsida Hutka MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Rod T Mitchell MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
Edinburgh Royal Hospital for Sick Children, Edinburgh, UK

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( 71 ). In this study, testis tissue was xenografted into immunocompromised host mice. Smooth muscle actin (SMA; a functional marker of PTM cells) expression in non-irradiated tissues was reported to appear following the 6.5 months of xenografting

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0382
Volume/Issue:
Volume 7: Issue 2
Open access
Serena Martinelli Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Mario Maggi Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy

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Elena Rapizzi Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

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subcutaneously into NOD scid gamma (NSG) mice by using a previously described protocol ( 46 ). To generate primary cell cultures, minced xenograft tissue was dissociated in collagenase followed by trypsin ( 30 ). The utilisation of xenografts to develop cell

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0472
Volume/Issue:
Volume 9: Issue 12
Open access
Nassim Ghaffari-Tabrizi-Wizsy Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Christina Angelika Passegger Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Laura Nebel Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Fabian Krismer Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Gudrun Herzer-Schneidhofer Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Gert Schwach Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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Roswitha Pfragner Otto Loewi Research Center – Immunology and Pathophysiology, Medical University of Graz, Graz, Austria

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. Written informed consent was obtained from all patients. The study was approved by the Ethical Committee of the Medical University of Graz (# 18-182 ex 06/07). CAM xenografts We performed the ex ovo CAM method according to Deryugina et al . ( 15

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0431
Volume/Issue:
Volume 8: Issue 5
Open access
Renea A Taylor Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Jennifer Lo Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Natasha Ascui Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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Matthew J Watt Department of Physiology, Cancer Program and Obesity and Metabolic Disease Program, Biomedicine Discovery Institute, Monash University, Wellington Road, Victoria 3800, Australia

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associated metabolic and endocrine co-morbidities including increased visceral adipose tissue deposition, glucose intolerance, mild hyperinsulinemia, dyslipidemia and subclinical inflammation. Xenograft studies that involve subcutaneous injection of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-15-0080
Volume/Issue:
Volume 4: Issue 4
Open access
Maria Cristina De Martino Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy

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Richard A Feelders Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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Claudia Pivonello Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy

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Chiara Simeoli Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy

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Fortuna Papa Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy

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Annamaria Colao Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy

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Rosario Pivonello Dipartimento di Medicina Clinica e Chirurgia, Università Federico II, Naples, Italy

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Leo J Hofland Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

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, the inhibition of NCI-H295R xenograft growth has been reported using high everolimus dose ( 29 ). Additionally, sirolimus was found to significantly reduce cell survival and cortisol secretion only in selected ACC primary cultures ( 28 ). These data

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0224
Volume/Issue:
Volume 8: Issue 9
Open access
Eleftherios E Deiktakis Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece

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Eleftheria Ieronymaki Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece

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Peter Zarén Department of Translational Medicine, Lund University, Malmö, Sweden

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Agnes Hagsund Department of Translational Medicine, Lund University, Malmö, Sweden

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Elin Wirestrand Department of Translational Medicine, Lund University, Malmö, Sweden

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Johan Malm Department of Translational Medicine, Lund University, Malmö, Sweden

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Christos Tsatsanis Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Greece

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Ilpo T Huhtaniemi Department of Translational Medicine, Lund University, Malmö, Sweden
Imperial College London, Institute of Reproductive and Developmental Biology, London, UK

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Aleksander Giwercman Department of Translational Medicine, Lund University, Malmö, Sweden
Malmö University Hospital, Reproductive Medicine Center, Malmö, Sweden

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Yvonne Lundberg Giwercman Department of Translational Medicine, Lund University, Malmö, Sweden

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line-derived xenograft (PC-3, DU145) growth in intact and degarelix-suppressed nude mice ( 8 ). In humans, a crossover study from agonist (leuprolide) to antagonist (degarelix) demonstrated better prostate cancer control with the latter, with a

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0639
Volume/Issue:
Volume 11: Issue 6
Open access