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M P Schuijt, C G J Sweep, R van der Steen, A J Olthaar, N M M L Stikkelbroeck, H A Ross and A E van Herwaarden

:// ) 10 Sarlis NJ Weil SJ Nelson LM . Administration of metformin to a diabetic woman with extreme hyperandrogenemia of nontumoral origin: management of infertility and prevention of inadvertent masculinization of a female fetus

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Milène Tetsi Nomigni, Sophie Ouzounian, Alice Benoit, Jacqueline Vadrot, Frédérique Tissier, Sylvie Renouf, Hervé Lefebvre, Sophie Christin-Maitre and Estelle Louiset

) , whereas in women of reproductive age, the great majority of adrenal oncocytomas are nonfunctional (21) . We report herein a very unusual case of hyperandrogenism, in a young woman presenting with an adrenocortical oncocytoma. We have investigated the

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Monika Bilic, Huma Qamar, Akpevwe Onoyovwi, Jill Korsiak, Eszter Papp, Abdullah Al Mahmud, Rosanna Weksberg, Alison D Gernand, Jennifer Harrington and Daniel E Roth

. Results In total, 559 woman–infant pairs were included in the study. Baseline characteristics did not differ across supplementation groups ( Table 1 ). The main findings including adverse event rates were previously described ( 28 ). Table 1

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Dorte Glintborg, Katrine Hass Rubin, Mads Nybo, Bo Abrahamsen and Marianne Andersen


To investigate risk of thyroid disease in Danish women with PCOS.


National register-based study on women with PCOS in Denmark. 18,476 women had a diagnosis of PCOS in the Danish National Patient Register. PCOS Odense University Hospital (PCOS OUH, n = 1146) was an embedded cohort of women with PCOS and clinical and biochemical examination. Three age-matched controls were included for each woman with PCOS (n = 54,757). The main outcome measures were thyroid disease (hypothyroidism, Graves’ disease, goiter, thyroiditis) according to hospital diagnosis codes and/or inferred from filled medicine prescriptions. Associations between baseline TSH and development of cardio-metabolic disease was examined in PCOS OUH.


The median (quartiles) age at inclusion was 29 (23–35) years and follow-up duration was 11.1 (6.9–16.0) years. The hazard ratio (95% CI) for thyroid disease development was 2.5 (2.3–2.7) (P < 0.001). The event rate of thyroid disease was 6.0 per 1000 patient-years in PCOS Denmark versus 2.4 per 1000 patient-years in controls (P < 0.001). Women in PCOS OUH with TSH ≥2.5 mIU/L (n = 133) had higher BMI (median 29 vs 27 kg/m2), wider waist, higher triglycerides and free testosterone by the time of PCOS diagnosis compared to women in PCOS OUH with TSH <2.5 mIU/L (n = 588). Baseline TSH did not predict later development of cardio-metabolic diseases in PCOS OUH.


The event rate of thyroid disease was significantly and substantially higher in women with PCOS compared to controls.

Open access

Magaly Zappa, Olivia Hentic, Marie-Pierre Vullierme, Matthieu Lagadec, Maxime Ronot, Philippe Ruszniewski and Valérie Vilgrain

( Fig. 1 ). Intraobserver variability was assessed for one reader (MZ) by repeating the assessment of tumour burden in all patients six months later. Figure 1 (A) 57-year-old woman with liver metastases from an ileal neuroendocrine tumour. Liver

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Alice S Ryan, John C McLenithan and Gretchen M Zietowski

little is known about lipoprotein and glucose metabolism in middle-aged and older woman with a prior history of GDM. We hypothesized that pre- and postmenopausal women who have a history of GDM would be more obese with lower aerobic fitness, have greater

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Sanna Mustaniemi, Marja Vääräsmäki, Johan G Eriksson, Mika Gissler, Hannele Laivuori, Hilkka Ijäs, Aini Bloigu, Eero Kajantie and Laure Morin-Papunen

clarify whether the performance of an early OGTT is necessary for all pregnant women with PCOS regardless of their BMI. Second, we wanted to investigate the role of other shared risk factors for PCOS and GDM, such as overweight or obesity, the woman’s own

Open access

Joakim Crona, Alberto Delgado Verdugo, Dan Granberg, Staffan Welin, Peter Stålberg, Per Hellman and Peyman Björklund

negatives generated by NGS ( Supplementary Table 1 ). Figure 2 Detailed coverage at bases annotated for PCC susceptibility genes. Patient 1: SDHC variant of uncertain clinical significance A 61-year-old woman was investigated due to therapy

Open access

Kaisu Luiro, Kristiina Aittomäki, Pekka Jousilahti and Juha S Tapanainen

-nuclear SSA autoantibodies (anti-Sjögren’s-syndrome-related antigen A), had a total AV block. Otherwise the children were healthy, and all except one were full term. Ten women delivered vaginally, four women had had an elective cesarean section and one woman

Open access

Yessica Agudelo-Zapata, Luis Miguel Maldonado-Acosta, Héctor Fabio Sandoval-Alzate, Natalia Elvira Poveda, María Fernanda Garcés, Jonathan Alexander Cortés-Vásquez, Andrés Felipe Linares-Vaca, Carlos Alejandro Mancera-Rodríguez, Shahar Alexandra Perea-Ariza, Karen Yuliana Ramírez-Iriarte, Camilo Andrés Castro-Saldarriaga, Juan Manuel Arteaga-Diaz, Roberto Franco-Vega, Edith Ángel-Müller, Arturo José Parada-Baños and Jorge E Caminos

4 h after 20 weeks of gestation (in a woman with previously normal blood pressure) and proteinuria >300 mg by collection of 24-h urine ( 8 ). Severity features include thrombocytopenia, impaired liver function, progressive renal insufficiency