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Morten Winkler Møller Department of Neurosurgery, Odense University Hospital, Odense C, Denmark
Clinical Institute, University of Southern Denmark, Odense C, Denmark

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Marianne Skovsager Andersen Clinical Institute, University of Southern Denmark, Odense C, Denmark
Department of Endocrinology, Odense University Hospital, Odense C, Denmark

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Christian Bonde Pedersen Department of Neurosurgery, Odense University Hospital, Odense C, Denmark
Clinical Institute, University of Southern Denmark, Odense C, Denmark

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Bjarne Winther Kristensen Clinical Institute, University of Southern Denmark, Odense C, Denmark
Department of Pathology, Odense University Hospital, Odense C, Denmark

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Frantz Rom Poulsen Department of Neurosurgery, Odense University Hospital, Odense C, Denmark
Clinical Institute, University of Southern Denmark, Odense C, Denmark

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). For other PAs, except prolactinomas, surgery is the first choice of treatment. The primary surgical technique has been transsphenoidal surgery since Hardy introduced surgical microscopes in 1962 ( 9 ). Further development of this technique has improved

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0140
Volume/Issue:
Volume 7: Issue 7
Open access
Liang Xue Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
Department of Neurosurgery, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China

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Jianwu Wu Department of Neurosurgery, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China

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Jie Chen Department of Radiology, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China

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Yongkai Yang Department of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China

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complication following transsphenoidal surgery (TSS) ( 1 , 2 ), and the clinical management of DI depends greatly on the clinician’s experience with DI. Failure to treat DI quickly can lead to hyperosmolar dehydration with corresponding clinical manifestations

Article Type:
Research Article
Collections:
Pituitary and Hypothalamus
DOI:
https://doi.org/10.1530/EC-22-0187
Volume/Issue:
Volume 11: Issue 11
Open access
Ida Staby Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Jesper Krogh Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Marianne Klose Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Jonas Baekdal Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark

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Lars Poulsgaard Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Jacob Bertram Springborg Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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Mikkel Andreassen Department of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Clinical Sciences, Copenhagen University, Copenhagen, Denmark

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to investigate the overall effect of transsphenoidal surgery on the pituitary endocrine function by comparing the numbers of insufficient axis before and after transsphenoidal surgery in a cohort of consecutive patients treated within the last 2 years

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0155
Volume/Issue:
Volume 10: Issue 7
Open access
Kunzhe Lin Department of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, China
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Lingling Lu Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Zhijie Pei Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Shuwen Mu Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China

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Shaokuan Huang Department of Neurosurgery, Guiqian International General Hospital, Guiyang, China

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Shousen Wang Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
Department of Neurosurgery, 900th Hospital, Fuzhou, China

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Introduction Delayed hyponatremia refers to hyponatremia that occurs ≥3 days after transsphenoidal surgery (TSS) ( 1 ). Patients with hyponatremia may have various clinical manifestations, ranging from asymptomatic to mild (headache, nausea

Article Type:
Research Article
Collections:
Pituitary and Hypothalamus
DOI:
https://doi.org/10.1530/EC-21-0497
Volume/Issue:
Volume 11: Issue 1
Open access
Nidan Qiao Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
Harvard Medical School, Boston, Massachusetts, USA

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Introduction Cushing’s disease (CD) is a subtype of pituitary adenoma with hypercortisolism and presents a particular challenge to neurosurgeons. Transsphenoidal surgery (TS) has long been the standard of care for patients with CD ( 1 , 2

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-17-0312
Volume/Issue:
Volume 7: Issue 1
Open access
Alberto Giacinto Ambrogio Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Massimiliano Andrioli Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Martina De Martin Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Francesco Cavagnini Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Francesca Pecori Giraldi Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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assess the pattern of ACTH/cortisol responses to desmopressin in the years following transsphenoidal surgery in patients with Cushing’s disease on long-term remission and to establish whether changes in the response to desmopressin in patients during

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0292
Volume/Issue:
Volume 6: Issue 8
Open access
Prachi Bansal Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Anurag Lila Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Manjunath Goroshi Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Swati Jadhav Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Nilesh Lomte Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Kunal Thakkar Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Atul Goel Department of Neurosurgery, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Abhidha Shah Department of Neurosurgery, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Shilpa Sankhe Department of Radiology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Naina Goel Department of Pathology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Neelam Jaguste Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Tushar Bandgar Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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Nalini Shah Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India

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mortality ( 2 ). Transsphenoidal surgery (TSS) of pituitary adenoma is the primary treatment modality, with varying remission rates (52–96.6%) reported across different centres ( 3 ). Various demographic, biochemical, radiological and histopathological

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0175
Volume/Issue:
Volume 6: Issue 8
Open access
Emmanuelle Motte UFR des Sciences de la Santé, Simone Veil, Université Versailles St-Quentin en Yvelines, Montigny le Bretonneux, France
Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France

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Anya Rothenbuhler Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France

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Stephan Gaillard Department of Neurosurgery, Foch Hospital, Suresnes, France

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Najiba Lahlou APHP, Department of Hormonal Biology, Cochin Hospital, Paris, France

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Cécile Teinturier Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France

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Régis Coutant Department of Pediatric Endocrinology, Angers University Hospital, Angers, France

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Agnès Linglart Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France

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suspected ( 9 ), the treatment remains a challenge. The gold standard treatment for both pediatric and adult patients with CD is transsphenoidal surgery (TSS) with selective microadenomectomy, but the failure rate is about 25–50% ( 10 , 11 , 12 , 13 , 14

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0215
Volume/Issue:
Volume 7: Issue 12
Open access
Marta Araujo-Castro Neuroendocrinology Unit, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto de Investigación Biomédica Ramón y Cajal, Madrid, Spain

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Héctor Pian Endocrinology Unit, Department of Pathology, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Ignacio Ruz-Caracuel Endocrinology Unit, Department of Pathology, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Alberto Acitores Cancela Neuroendocrinology Unit, Department of Neurosurgery, Hospital Universitario Ramón y Cajal, Madrid, Spain

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Eider Pascual-Corrales Neuroendocrinology Unit, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Instituto de Investigación Biomédica Ramón y Cajal, Madrid, Spain

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Víctor Rodríguez Berrocal Neuroendocrinology Unit, Department of Neurosurgery, Hospital Universitario Ramón y Cajal, Madrid, Spain
Endoscopic Skull Base Unit, Department of Neurosurgery, Hospital Universitario HM Puerta del Sur, Madrid, Spain

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active acromegaly are associated with higher mortality ( 1 ). Transsphenoidal surgery is generally considered the first-line treatment of choice in acro-megaly ( 1 ). However, although surgical remission is achieved in up to 100% of microadenomas in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0414
Volume/Issue:
Volume 10: Issue 1
Open access
Kunal Thakkar Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Swati Ramteke-Jadhav Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Rajeev Kasaliwal Department of Endocrinology, Mahatma Gandhi Medical College & Hospital, Jaipur, India

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Saba Samad Memon Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Virendra Patil Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Puja Thadani Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Nilesh Lomte Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Shilpa Sankhe Department of Radiology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Atul Goel Department of Neurosurgery, Seth G S Medical College & KEM Hospital, Mumbai, India

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Sridhar Epari Department of Pathology, Tata Memorial Centre, Mumbai, India

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Naina Goel Department of Neuropathology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Anurag Lila Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Nalini S Shah Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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Tushar Bandgar Department of Endocrinology, Seth G S Medical College & KEM Hospital, Mumbai, India

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patients with abscesses. Hypopituitarism was seen in all except one patient (case 4). Cortisol and gonadotropin axes were the commonest axes involved followed by thyroid axis. Three patients had elevated prolactin levels. Seven patients underwent trans-sphenoidal

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0497
Volume/Issue:
Volume 9: Issue 2
Open access