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Manon Engels, Paul N Span, Rod T Mitchell, Joop J T M Heuvel, Monica A Marijnissen-van Zanten, Antonius E van Herwaarden, Christina A Hulsbergen-van de Kaa, Egbert Oosterwijk, Nike M Stikkelbroeck, Lee B Smith, Fred C G J Sweep and Hedi L Claahsen-van der Grinten

literature ( 14 , 15 ). GATA transcription factors are involved in development (by regulating cell fate specification) and differentiation in all eukaryotic organisms. These factors are able to bind to a consensus DNA element, WGATAR, known as the GATA

Open access

Katherine U Gaynor, Irina V Grigorieva, Samantha M Mirczuk, Sian E Piret, Kreepa G Kooblall, Mark Stevenson, Karine Rizzoti, Michael R Bowl, M Andrew Nesbit, Paul T Christie, William D Fraser, Tertius Hough, Michael P Whyte, Robin Lovell-Badge and Rajesh V Thakker

parathyroid-specific transcription factor glial cells missing B ( GCMB ) result in defective parathyroid gland development ( 4 , 5 ), and gain-of-function mutations in the calcium-sensing receptor (CaSR) may suppress parathyroid gland function in association

Open access

I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder and K Svechnikov

, little is presently known about the potential relationship between the expression of steroidogenic enzymes and of associated transcription factors by the HFA at early stages of the gland development. Accordingly, in the present study, we carried out a

Open access

Fernando Aprile-Garcia, María Antunica-Noguerol, Maia Ludmila Budziñski, Ana C Liberman and Eduardo Arzt

inflammation. On a molecular level, the appearance of proinflammatory signals culminates predominantly in the activation of activator protein 1 (AP1) and nuclear factor-κB (NF-κB). In turn, both transcription factors (TFs) induce the expression of the

Open access

Satoshi Inoue, Taichi Mizushima, Hiroki Ide, Guiyang Jiang, Takuro Goto, Yujiro Nagata, George J Netto and Hiroshi Miyamoto

radiotherapy ( 4 ) in bladder cancer cells. However, the underlying mechanism of how AR and related signals modulate bladder carcinogenesis and tumor cell growth remains largely unknown. ATF2 (activating transcription factor 2) is a member of the activating

Open access

Peter L Kristensen, Ulrik Pedersen-Bjergaard, Rikke Due-Andersen, Thomas Høi-Hansen, Lise Grimmeshave, Valeriya Lyssenko, Leif Groop, Jens J Holst, Allan A Vaag and Birger Thorsteinsson

candidate risk genes for type 2 diabetes, the T allele of rs7903146 transcription factor 7-like 2 ( TCF7L2 ) has been shown to confer the hitherto strongest association with type 2 diabetes, with a per allele odds ratio of 1.4 ( 22 , 23 , 24 ). During the

Open access

Emma Jernberg, Anders Bergh and Pernilla Wikström

thousands of androgen-regulated genes depending on cell type. In prostate epithelial cells the AR regulates the expression of NKX3.1 and FOX family transcription factors, IGF1R , UBE2C , UGT2B15 , KLK3 , TMPRSS2 , FKBP5 and other genes controlling

Open access

Hichem Bouguerra, Amal Gorrab, Stephan Clavel, Hammouda Boussen, Jean François Louet and Asma Gati

Large prospective studies established a link between obesity and breast cancer (BC) development. Yet, the mechanisms underlying this association are not fully understood. Among the diverse adipocytokine secreted by hypertrophic adipose tissue, leptin is emerging as a key candidate molecule linking obesity and cancer, since it promotes proliferation and invasiveness of tumors. However, the potential implication of leptin on tumor escape mechanisms remains unknown. This study aims to explore the effect of leptin on tumor resistance to NK lysis and the underlying mechanism. We found that leptin promotes both BC resistance to NK92-mediated lysis and β oxidation on MCF-7, by the up-regulation of a master regulator of mitochondrial biogenesis, peroxisome proliferator activated receptor coactivator-1 α (PGC-1α). Using adenoviral approaches, we show that acute elevation of PGC-1α enhances the fatty acid oxidation pathway and decreases the susceptibility of BC cells to NK92-mediated lysis. Importantly, we identified new regulatory functions of PGC-1α and leptin in regulating the expression of hypoxia-inducible factor-1 alpha (HIF-1α by tumor cells, a transcriptional factor with pleiotropic role in cancer. We further demonstrate that basal BC cells MDA-MB-231 and BT-20 exhibit an increased PGC-1α mRNA level, an enhanced activity of oxidative phosphorylation and are more resistance to NK92 lysis in comparison with luminal BC cells (MCF7 and MDA-361). Altogether, our results demonstrate for the first time how leptin could promote tumor resistance to immune attacks. Reagents blocking leptin or PGC-1α activity might aid in developing new therapeutic strategies to limit tumor development in obese BC patients.

Open access

A H Ludwig-Slomczynska, S Borys, M T Seweryn, J Hohendorff, P Kapusta, B Kiec-Wilk, E Pitera, P P Wolkow and M T Malecki

transcription factors using the expression ( 9 ) and the methylation data. Using the above-described approach together with standard Wilcoxon’s signed-rank test, we found transcription factors that were differentially activated pre and post treatment in the NPWT

Open access

Xuhua Mao, Hucheng Chen, Junmin Tang, Liangliang Wang and Tingting Shu

three β-cell-specific transcription factors: Pdx-1, neurogenic differentiation 1 (NeuroD1) and V-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MafA). RT-PCR analysis of the effects of gluco-toxicity showed significantly decreased expression