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S C Clement, W E Visser, C A Lebbink, D Albano, H L Claahsen-van der Grinten, A Czarniecka, R P Dias, M P Dierselhuis, I Dzivite-Krisane, R Elisei, A Garcia-Burillo, L Izatt, C Kanaka-Gantenbein, H Krude, L Lamartina, K Lorenz, M Luster, R Navardauskaitė, M Negre Busó, K Newbold, R P Peeters, G Pellegriti, A Piccardo, A L Priego, A Redlich, L de Sanctis, M Sobrinho-Simões, A S P van Trotsenburg, F A Verburg, M Vriens, T P Links, S F Ahmed, and H M van Santen

Background Pediatric differentiated thyroid carcinoma (DTC) is a rare disease, although it is the most frequent endocrine malignancy in children, representing 2–4% of all pediatric malignancies. According to the Surveillance, Epidemiology, and

Open access

Yong Yu, Lin-Lin Shi, Hua-Wei Zhang, and Qian Wang

Introduction Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma, accounting for 84% of all thyroid cancers ( 1 ). The majority of PTCs have a low tumor growth rate and a favorable prognosis, but few of them are highly

Open access

Carina Hasenoehrl, Gert Schwach, Nassim Ghaffari-Tabrizi-Wizsy, Robert Fuchs, Nadine Kretschmer, Rudolf Bauer, and Roswitha Pfragner

Introduction Medullary thyroid carcinomas (MTC) arise from the parafollicular C-cells of the thyroid and account for 5–10% of all thyroid cancers ( 1 , 2 ). MTCs are calcitonin-producing tumors that occur sporadically in 70–80% of the cases

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Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Per Løgstrup Poulsen, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cilius Nielsen, Kim Brixen, Christian Godballe, and Danish Thyroid Cancer Group (DATHYRCA)

Introduction Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor with an incidence of 0.19 per 100,000 per year and a prevalence of 3.8 per 100,000 inhabitants. MTC is divided into a sporadic and hereditary type accounting for

Open access

Anello Marcello Poma, Riccardo Giannini, Paolo Piaggi, Clara Ugolini, Gabriele Materazzi, Paolo Miccoli, Paolo Vitti, and Fulvio Basolo

Introduction The incidence of follicular thyroid carcinoma (FTC) has decreased over the last years ( 1 ), but still accounts for 10–15% of all thyroid cancers ( 2 ). The distinction between follicular adenoma (FA) and FTC, conventionally

Open access

Lauren E Henke, John D Pfeifer, Thomas J Baranski, Todd DeWees, and Perry W Grigsby

Introduction Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, accounting for 88% of thyroid carcinomas ( 1 , 2 ). Prognosis remains excellent and treatment, typically involving surgery followed by radioactive iodine

Open access

Andrea Mazurat, Andrea Torroni, Jane Hendrickson-Rebizant, Harbinder Benning, Richard W Nason, and K Alok Pathak

Introduction Well-differentiated thyroid carcinoma (WDTC) represents a group of thyroid cancers that are associated with increasing incidence and excellent posttreatment outcome (1) . This group comprises different histological types, the most

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David T Broome, Gauri B Gadre, Ehsan Fayazzadeh, James F Bena, and Christian Nasr

diagnosed cases in 2020, representing 2.9% of all new cancer diagnoses in the United States ( 1 ). The incidence of thyroid carcinoma is 15.7 per 100,000 men and women per year and represents 0.4% of all cancer deaths currently. The incidence has increased

Open access

Huy Gia Vuong, Uyen N P Duong, Ahmed M A Altibi, Hanh T T Ngo, Thong Quang Pham, Hung Minh Tran, Greta Gandolfi, and Lewis Hassell

poor survival outcomes. TERT promoter mutations are not prevalent in PTCs but are more frequently detected in poorly differentiated and anaplastic thyroid carcinoma ( 45 , 46 ). On the other hand, Landa and coworkers reported that TERT promoter

Open access

June Young Choi, Jin Wook Yi, Jun Hyup Lee, Ra-Yeong Song, Hyeongwon Yu, Hyungju Kwon, Young Jun Chai, Su-jin Kim, and Kyu Eun Lee

Introduction Thyroid carcinoma is the most common endocrine malignancy worldwide, the incidence of which is increasing. The most common subtype of thyroid carcinoma is papillary carcinoma (PTC), accounting for 80–90% of all cases ( 1